Influence of Preoperative Chemotherapy on CT Volumetric Liver Regeneration Following Right Hemihepatectomy

Dello, Simon A.W.G.; Kele, Petra G.; Porte, Robert J.; Dam, Ronald M. van; Klaase, Joost M.; Verhoef, C.; Gulik, Thomas van; Molenaar, Q.; Bosscha, K.; Jagt, Eric J. van der; Dejong, Cornelis H. C.; Boer, Marieke T. de

doi:10.1007/s00268-013-2278-0

Cited by 16 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the contrary, Goéré et al concluded that the continuation of chemotherapy during PVE is safe and did not affect the hypertrophy of the FLR. Prolonged time interval of more than 3 months, however, did not reveal any significance as reported by Dello et al Our results showed no relation between liver regeneration and time interval.…”

Section: Discussioncontrasting

confidence: 49%

“…The results reported from these studies have mostly concluded that neoadjuvant chemotherapy does not have a negative impact on liver regeneration; however, these studies included relatively small sample size, ranging between 20 and 112 patients. Sturesson et al have shown that preoperative chemotherapy negatively affects postoperative and post‐embolization liver regeneration , although it has also been concluded in several studies that neoadjuvant chemotherapy may not hinder liver hypertrophy in patients undergoing hepatectomy or PVE .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neoadjuvant chemotherapy does not impair liver regeneration following hepatectomy or portal vein embolization for colorectal cancer liver metastases

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Neoadjuvant chemotherapy does not impair liver regeneration following hepatectomy or portal vein embolization for colorectal cancer liver metastases

et al. 2016

View full text Add to dashboard Cite

show abstract

“…These observations are compatible with previous reports that investigated liver regeneration after simple hepatectomy without EBR. [3][4][5] Interestingly, there was a significant negative correlation between KGR PVE and KGR POD7 . Patients who achieved more liver regeneration following PVE do achieve less liver regeneration following hepatectomy.…”

Section: Discussionmentioning

confidence: 99%

“…A LTHOUGH THERE ARE many studies investigating liver regeneration after partial hepatectomy, 1,2 most of these studies evaluated liver regeneration later in the postoperative course (approximately 1 month after resection), and the data on the early phase (1 week after resection) are scarce. [3][4][5][6] Furthermore, all previous reports [3][4][5][6] focused on liver regeneration after hepatectomy "without" extrahepatic bile duct resection (EBR) and the data exclusively focused on the regeneration after extended hepatectomy with EBR are not available.…”

Section: Introductionmentioning

confidence: 99%

Discrepancy between volume and functional recovery in early phase liver regeneration following extended hepatectomy with extrahepatic bile duct resection

Maeda

Yokoyama

Igami

et al. 2019

Hepatology Research

View full text Add to dashboard Cite

Aim To elucidate the clinical factors having an impact on liver regeneration rate following preoperative portal vein embolization (PVE) and subsequent extended hepatectomy. The correlation between liver volume and functional recovery after extended hepatectomy was also investigated. Methods Records of patients who underwent extended hepatectomy with extrahepatic bile duct resection following PVE for perihilar cholangiocarcinoma were reviewed retrospectively with attention to liver regeneration. All patients underwent computed tomography before PVE, after PVE (immediately before surgery), and on postoperative day (POD) 7. The kinetic growth rate (KGR) was calculated as the percent increase in liver volume relative to the future liver remnant volume per day after PVE (KGRPVE) and after POD 7 (KGRPOD7) using the computed tomography images before PVE, after PVE, and on POD 7. Results In the 289 study patients, the median of KGRPVE was 1.35%/day whereas that of KGRPOD7 was 5.56%/day. The extent of liver resection had the greatest impact on both KGRPVE and KGRPOD7 and the impacts of other factors were less. There was a significant negative correlation between KGRPVE and KGRPOD7 (P = 0.002). No correlations were observed between KGRPVE or KGRPOD7 and serum total bilirubin and prothrombin time – international normalized ratio on POD 7, nor in the incidence of liver failure after surgery. Conclusions Early phase liver regeneration after extended hepatectomy was largely influenced by the extent of liver resection and showed no correlation with the indices of liver failure. There was a discrepancy between volume and functional recovery in early phase liver regeneration.

show abstract

“…CT examination is mainly used to determine postoperative complications and identify residual tumor area, which helps direct following treatment [14]. Postoperative digital subtraction angiography (DSA) detects the pathological blood vessels and the number of tumors that are stained [15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Transcatheter Arterial Chemoembolization Combined with Argon–Helium Cryosurgery System on the Changes of NK Cells and T Cell Subsets in Peripheral Blood of Hepatocellular Carcinoma Patients

Huang¹,

Wang²,

Huang³

2015

Cell Biochem Biophys

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is one of the most aggressive tumors in humans. T lymphocytes and natural killer (NK) cells are the body's first line of defense to prevent tumor cell growth. Previous studies have demonstrated that transcatheter arterial chemoembolization (TACE) combined with argon-helium cryosurgery system (AHCS) can effectively treat liver cancer. However, the mechanism of the treatment is unclear yet. In the current study, we investigated the effects of TACE combined with AHCS on the changes of T cell subsets and NK cells in peripheral blood of HCC. Our data show that alpha-fetoprotein (AFP) levels in peripheral blood were significantly up-regulated in HCC patients before treatment when compared with healthy people and reduced after TACE combined with AHCS treatment (P < 0.01). In addition, we found that CD4+ cells and NK cells decreased (P < 0.05) and CD8+ cells increased (P < 0.05) in HCC patients when compared with healthy people. After treatment, the CD4+ cells, CD4+/CD8+ ratio, and NK cells were dramatically increased in HCC patients (P < 0.05). In contrast, CD8+ cells were significantly decreased (P < 0.05). TACE combined with AHCS treatment significantly prolonged 1-year survival rate of HCC patients and did not show significant side effects. Taken together, our data indicate that TACE combined with AHCS treatment improves patients' immune system. It is a feasible and effective therapeutic method for HCC patients.

show abstract

Influence of Preoperative Chemotherapy on CT Volumetric Liver Regeneration Following Right Hemihepatectomy

Abstract: Preoperative chemotherapy does not seem to have a negative impact on early liver regeneration after partial liver resection.

Cited by 16 publications

References 36 publications

Neoadjuvant chemotherapy does not impair liver regeneration following hepatectomy or portal vein embolization for colorectal cancer liver metastases

Neoadjuvant chemotherapy does not impair liver regeneration following hepatectomy or portal vein embolization for colorectal cancer liver metastases

Discrepancy between volume and functional recovery in early phase liver regeneration following extended hepatectomy with extrahepatic bile duct resection

Effect of Transcatheter Arterial Chemoembolization Combined with Argon–Helium Cryosurgery System on the Changes of NK Cells and T Cell Subsets in Peripheral Blood of Hepatocellular Carcinoma Patients

Contact Info

Product

Resources

About