Influence of Prenatal Maternal Anxiety on Emotionality in Young Rats

Thompson, William R.

doi:10.1126/science.125.3250.698

Cited by 263 publications

(103 citation statements)

References 2 publications

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“…Both of these procedures have been reported to produce behavioral abnormalities later in adulthood. Prenatal stress has been reported to alter fear-motivated and defensive behavior (Thompson, 1957;Archer and Blackman 1971), to enhance amphetamine-induced locomotor activity as well as amphetamine self-administration (Deminière et al, 1992), and to increase signs of anxiety (Fride and Weinstock, 1988;Wakshlak and Weinstock, 1990). On the other hand, neonatal stimulation has a number of clear behavioral effects in adulthood (Meaney et al, 1989) that include enhanced exploratory behavior and an attenuation of novelty-induced anxiety (Levine, 1957(Levine, , 1962Levine et al, 1967;Ader and Grota, 1969;Hess et al, 1969).…”

Section: Abstract: Nitric Oxide; Nadph-diaphorase; Hippocampus; Hypomentioning

confidence: 99%

Neonatal Nonhandling andIn UteroPrenatal Stress Reduce the Density of NADPH-Diaphorase-Reactive Neurons in the Fascia Dentata and Ammon’s Horn of Rats

et al. 1997

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The density of nitric oxide (NO)-producing neurons in the fascia dentata and Ammon's horn was assessed in 6-month-old male rats using NADPH-diaphorase (NADPH-d) histochemistry. Two separate experiments investigated whether (1) the complete absence of neonatal handling or (2) the administration of periodic prenatal stress could affect the expression and distribution of NADPH-d reactivity in the hippocampus, when compared with rats raised in normal standard laboratory conditions. Experiment 1 demonstrated that adult rats that received no handling during neonatal development (from birth to postnatal day 22) showed a very substantial reduction in NADPH-d-positive neurons per unit area throughout the entire hippocampus when compared with rats that received regular daily handling in this period. Quantitative analysis further revealed that this effect was significantly more pronounced in Ammon's horn than in the fascia dentata, and within Ammon's horn the dorsal region was selectively more affected. Experiment 2 showed that prenatal stress, which involved the administration of daily restraint stress to pregnant dams throughout the gestation period, also led to a reduction in NADPH-d reactivity in the hippocampus of the offspring of these dam when they reached adulthood.The present results suggest that behavioral manipulations in the early neonatal or prenatal period can significantly alter the neurodevelopment of the hippocampal NO system and these changes might be related to some of the behavioral abnormalities that emerge later in adulthood.

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Section: Abstract: Nitric Oxide; Nadph-diaphorase; Hippocampus; Hypomentioning

confidence: 99%

Neonatal Nonhandling andIn UteroPrenatal Stress Reduce the Density of NADPH-Diaphorase-Reactive Neurons in the Fascia Dentata and Ammon’s Horn of Rats

et al. 1997

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“…ulcers) of mild prenatal stress, such as maternal emotionality, may appear only under appropriate environmental conditions. Thompson (1957) has suggested that the exogenous administration of certain chemicals may mimic prenatal maternal emotionality.…”

Section: Introductionmentioning

confidence: 99%

“…Thompson & Goldenberg, 1962) and behaviorally (e.g. Thompson, 1957), with the timing of the stress being an important variable (e.g. Hartel & Hartel, 1960).…”

Section: Introductionmentioning

confidence: 99%

The effects of prenatal injections of adrenalin chloride and d- amphetamine sulfate on subsequent emotionality and ulcer-proneness of offspring

Bell

Drucker

Woodruff³

1965

Psychon Sci

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Twenty pregnant female rats were each given one injection of (1) 1.5cc/kg body weightofa1:1000 solution of adrenal in chloride, (2) 3.0mg/kg body weight of a 0.9mg/1.0cc solution of d-amphetamine sulfate, or (3) 1.5cc/kg body weight of distilled water. Injections were administered intraperitoneally either between 6 :;tnd 9 days post-conception, during which time the fetal stomach and intestine are developing, or between 12 and 15 days post-conception. Following normal rearing, offspring were subjected to immobilization stress, with pre-and post-measures of emotionality, follOwing which they were assayed for ulcers. The results indicate modified emotionality as a function of the prenatal treatments, and a significantly higher frequency of ulceration in those Ss whose mothers had been injected with adrenalin at the time of the fetal stomach development.

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“…Prenatal stress in animals produces a wide range of behavioral and physiological changes in both the mother and her offspring (Beydoun & Saftlas, 2008;Knackstedt, Hamelmann, & Arck, 2005;Moore & Power, 1986;Thompson, 1957;Weinstock, 2008). Behavioral changes in the offspring include altered social behavior, conditioned avoidance, prepulse inhibition (PPI), and increased aggressive behavior, emotionality, propensity to administer drugs, and locomotor activity (Chapillon, Patin, Roy, Vincent, & Caston, 2002;Deminiere et al, 1992;Koenig et al, 2005;Lee, Brady, Shapiro, Dorsa, & Koenig, 2007;Lehmann, Stohr, & Feldon, 2000;Mintz, Yovel, Gigi, & Myslobodsky, 1998;Thomas, Hu, Lee, Bhatnagar, & Becker, 2009;Wakshlak & Weinstock, 1990).…”

mentioning

confidence: 99%

Early adversity and serotonin transporter genotype interact with hippocampal glucocorticoid receptor mRNA expression, corticosterone, and behavior in adult male rats.

Belay

Burton

Lovic

et al. 2011

Behavioral Neuroscience

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Despite its importance for development, relatively little is known about how allelic variation interacts with both pre-and postnatal stress. We examined the interaction between serotonin transporter (5-HTT) genotype, prenatal and postnatal stress on glucocorticoid receptor (GR) mRNA expression, corticosteroid stress responses, and behavior in adult male rats. Prenatal stress involved a daily restraint of pregnant dams from gestational Day 10 -21. Postnatal stress involved raising pups after parturition either by their mothers (MR) or in the artificial rearing (AR) paradigm, with or without additional "licking-like" stroking stimulation. 5-HTT genotype, hippocampal GR mRNA level, corticosteroid stress response, and behaviors including startle response, prepulse inhibition (PPI), and locomotor activity were measured in adult male rat offspring. We found significant genotype by prenatal stress interactions for hippocampal GR mRNA levels and for the corticosterone stress responses in adulthood. In contrast, behavioral endpoints tended to be more clearly affected by an interaction between genotype and postnatal environment. These findings suggest that allelic variation in the 5-HTT gene interacts with the prenatal environment to affect the hypothalamic-pituitary-adrenal (HPA) axis physiology and the postnatal environment to affect behavior. These results are the first to indicate a role for genetic variation in the 5-HTT gene in physiology and behavior in the rat.

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Influence of Prenatal Maternal Anxiety on Emotionality in Young Rats

Cited by 263 publications

References 2 publications

Neonatal Nonhandling andIn UteroPrenatal Stress Reduce the Density of NADPH-Diaphorase-Reactive Neurons in the Fascia Dentata and Ammon’s Horn of Rats

Neonatal Nonhandling andIn UteroPrenatal Stress Reduce the Density of NADPH-Diaphorase-Reactive Neurons in the Fascia Dentata and Ammon’s Horn of Rats

The effects of prenatal injections of adrenalin chloride and d- amphetamine sulfate on subsequent emotionality and ulcer-proneness of offspring

Early adversity and serotonin transporter genotype interact with hippocampal glucocorticoid receptor mRNA expression, corticosterone, and behavior in adult male rats.

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