Influence of Pregnant Parabiotic Partners on Time of Parturition in Rats

Mantalenakis, S.; Ketchel, Melvin M.

doi:10.1530/jrf.0.0110313

Cited by 2 publications

(2 citation statements)

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“…As applied to rat gestation and parturition, studies have been performed which revealed the ability of a gravid female 2 or 3 days earlier in gestation (i.e. mated later) to delay the onset of birth in the gravid female that had been impregnated earlier ( Mantalenakis and Ketchel, 1966 ). Interestingly, gravid females 4 days earlier in gestation than the partner did not delay the onset of labor ( Mantalenakis and Ketchel, 1966 ).…”

Section: Developing a Theoretical Evolutionary Framework To Gain Insimentioning

confidence: 99%

“…mated later) to delay the onset of birth in the gravid female that had been impregnated earlier ( Mantalenakis and Ketchel, 1966 ). Interestingly, gravid females 4 days earlier in gestation than the partner did not delay the onset of labor ( Mantalenakis and Ketchel, 1966 ). This suggests an inhibitory factor from the earlier gestation animal that rises through pregnancy is capable of inhibiting parturition.…”

Section: Developing a Theoretical Evolutionary Framework To Gain Insimentioning

confidence: 99%

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Developing a theoretical evolutionary framework to solve the mystery of parturition initiation

Rokas

Mesiano

Tamam

et al. 2020

eLife

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Eutherian mammals have characteristic lengths of gestation that are key for reproductive success, but relatively little is known about the processes that determine the timing of parturition, the process of birth, and how they are coordinated with fetal developmental programs. This issue remains one of biology's great unsolved mysteries and has significant clinical relevance because preterm birth is the leading cause of infant and under 5 year old child mortality worldwide. Here, we consider the evolutionary influences and potential signaling mechanisms that maintain or end pregnancy in eutherian mammals and use this knowledge to formulate general theoretical evolutionary models. These models can be tested through evolutionary species comparisons, studies of experimental manipulation of gestation period and birth timing, and human clinical studies. Understanding how gestation time and parturition are determined will shed light on this fundamental biological process and improve human health through the development of therapies to prevent preterm birth.

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Section: Developing a Theoretical Evolutionary Framework To Gain Insimentioning

confidence: 99%

Section: Developing a Theoretical Evolutionary Framework To Gain Insimentioning

confidence: 99%