Influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis subject to sex belonging in Russian ethnic group

Abstract

To study influence of polymorphic loci rs1800629 (TNFa), rs6074022 (CD40), rs187238 (IL-18), rs10492972 (KIF1B), rs4149584 (TNFRSF1A) on clinical features of multiple sclerosis (MS) subject to sex belonging in Omsk city and Omsk region. Methods: neurological examination, molecular-genetic, statistic analyses. 265 patients with multiple sclerosis and 576 healthy controls was observed. Results: observable polymorphic loci don’t associated with sex. In group of men dysfunction of the pyramidal, visual, pelvic functions on course of MS, in women group — dysfunction of the pyramidal functions, duration of the disease, height, CD40 genotipe.