Influence of polymer characteristics on drug loading into crospovidone

Application of Nilvadipine Solid Dispersion to Tablet Formulation and Manufacturing Using Crospovidone and Methylcellulose as Dispersion Carriers

“…The dissolution properties of a drug loading system using various grades of cl-PVP were reported, and the results showed that the dissolution of the drug was influenced by the physical state of the drug and the specific surface area of cl-PVP. 9) Therefore, to investigate the crystallinity of NIL in the CL, we prepared NIL/CL (1/4) solid dispersion by the solvent method, and performed powder X-ray diffraction and differential scanning calorimetry (DSC) by the previously reported methods.…”

Effect of Characteristics of Compounds on Maintenance of an Amorphous State in Solid Dispersion with Crospovidone

“…Previous reports have described the use of CrosPVP in SD prepared with solutions of drugs in organic solvents 6–10. However, there is a lack of information about what types of drugs can exist in the amorphous state in SD with CrosPVP.…”

“…GF was kept in an amorphous state in SD for more than 1 day, unlike NA and TP, but recrystallization occurred within 1 month. There have been reports that GF adopted an amorphous state in SD with CrosPVP,7,8 but these studies used a solvent method to prepare SD and the stability of the amorphous state was not mentioned. Vasanthavada et al20 reported that GF remained in an amorphous state in SD with PVP but recrystallized from SD with time.…”

Assessment of the X-ray diffraction–absorption method for quantitative analysis of largely amorphous pharmaceutical composites

“…the bio-availability) of poorly watersoluble drugs (Serajuddin, 1999), since the three-dimensional polymeric network physically constrains the formation of highly active amorphous and/or nanocrystalline drug phases (Chiou & Riegelman, 1971;Takayama et al, 1982). In past years, several techniques have been developed for achieving this process (Carli et al, 1986;Colombo & Pallado, 2001;Lovrecich, 1995). Nowadays, the state of the art is still evolving and pharmaceutical companies are expending much effort to overcome the weaknesses of the existing technologies and to look for more effective, easy and environmentally safe processes.…”

“…In the pharmaceutical ®eld, quantitative analysis is traditionally performed by differential scanning calorimetry (DSC) and X-ray diffraction (QXRD) (Carli et al, 1986;Theeuwes et al, 1974;Suryanarayanan, 1995). When a compound melt with decomposition and/or solid-phase interactions occurs during heating, the DSC technique cannot be applied.…”