Influence of polyelectrolyte multilayer adsorption on the temperature sensitivity of poly(N-isopropylacrylamide) (PNiPAM) microgels

Greinert, Nils; Richtering, Walter

doi:10.1007/s00396-004-1048-9

Cited by 37 publications

(49 citation statements)

References 17 publications

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“…[70] An interesting study by Greinert and Richtering involved the modulation of polyelectrolytic pNIPAm microgels by the adsorption of oppositely charged polyelectrolytes in solution. [81] The charge compensation and bridging effect of the polyelectrolyte adsorption have a profound effect on the LCST behavior of the microgels. These studies may offer insight into the swelling phenomena observed in microgel-based polyelectrolyte multilayers, [82][83][84][85] which are discussed in Section 3.1.…”

Section: Microgels and Nanogelsmentioning

confidence: 99%

Soft Nanotechnology with Soft Nanoparticles

2005

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The last decade of research in the physical sciences has seen a dramatic increase in the study of nanoscale materials. Today, "nanoscience" has emerged as a multidisciplinary effort, wherein obtaining a fundamental understanding of the optical, electrical, magnetic, and mechanical properties of nanostructures promises to deliver the next generation of functional materials for a wide range of applications. While this range of efforts is extremely broad, much of the work has focused on "hard" materials, such as Buckyballs, carbon nanotubes, metals, semiconductors, and organic or inorganic dielectrics. Meanwhile, the soft materials of current interest typically include conducting or emissive polymers for "plastic electronics" applications. Despite the continued interest in these established areas of nanoscience, new classes of soft nanomaterials are being developed from more traditional polymeric constructs. Specifically, nanostructured hydrogels are emerging as a promising group of materials for multiple biotechnology applications as the need for advanced materials in the post-genomic era grows. This review will present some of the recent advances in the marriage between water-swellable networks and nanoscience.

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Section: Microgels and Nanogelsmentioning

confidence: 99%

Soft Nanotechnology with Soft Nanoparticles

2005

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“…Richtering's group reported that the polyelectrolyte adsorption on charged microgel particles is a promising approach for design of new microgel architectures [116]. The adsorption of poly(diallyldimethylammonium chloride) (PDADMAC) on PNIPAAm-co-MAAc microgels was studied with regard to different ratios between the positive charges of PDADMAC and the negative charges originating from MAAc units [117].…”

Section: Incorporation Of Small Molecules Synthetic Polymers and Bimentioning

confidence: 99%

Microgels by Precipitation Polymerization: Synthesis, Characterization, and Functionalization

Pich

Richtering

2010

Advances in Polymer Science

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This chapter reviews recent work on the synthesis of aqueous microgel particles by precipitation polymerization. Precipitation polymerization allows flexible control over important physicochemical properties of aqueous microgels, such as size distribution, surface charge, chemical composition, and microstructure. The microgel systems discussed in this review are mainly based on poly(N-isopropyl acrylamide) and poly(N-vinylcaprolactam) due to their ability to react to external stimuli such as the pH or temperature of the surrounding medium. We discuss synthetic routes to obtain microgels based on homo-or copolymers as well as colloids with complex core-shell morphology. The functionalization of microgels is of crucial importance from the application point of view. Different routes for incorporation of functional groups, synthetic polymers, proteins, or nanoparticles in microgel structures are discussed.

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“…Its LCST is close to body temperature and is relatively insensitive to environmental conditions and may be modulated easily above 42°C which is hyperthermia temperature [6]. Slight variations of pH or concentration generally affect the LCST of poly(NIPAAm) by a few degrees only and, therefore, make it reliable under different environmental conditions [7,8].…”

Section: Introductionmentioning

confidence: 99%

A comparative study on thermoresponsive magnetic nanohydrogels: role of surface-engineered magnetic nanoparticles

et al. 2011

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A comparative study of thermoresponsive poly(Nisopropylacrylamide)(PNIPAAm)-chitosan (CS)-based magnetic nanohydrogels (MNHGs) encapsulating functionalized Fe 3 O 4 nanoparticles (NPs) in terms of the parameters governing their suitability for real hyperthermia is reported. Iron oxide NPs functionalized with (a) citric acid (CA-Fe 3 O 4 ), (b) ethylenediamine (Amine-Fe 3 O 4 ) and (c) dimercaptosuccininc (DMSAFe 3 O 4 ) have been synthesized and their encapsulation into MNHGs was obtained through physical encapsulation method. The structural characterizations of synthesized materials include X-ray diffraction, FT-IR, TGA, ICP-AES and X-ray photoelectron spectroscopy (XPS). Encapsulation of the functionalized NPs into MNHGs were observed in TEM micrographs, while SEM and AFM micrographs confirmed their spherical morphology (~250-300 nm). Lower critical solution temperature (LCST) variation was measured by UV-visible spectrophotometer and differential scanning calorimetry (DSC). MNHGs exhibited sufficient magnetization and heating ability for hyperthermia. Typically, hydrogels containing CA-Fe 3 O 4 (50 mg/ml) raised the temperature of the medium to 43°C, a suitable dose for in vivo application in tumor-bearing mice.

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Influence of polyelectrolyte multilayer adsorption on the temperature sensitivity of poly(N-isopropylacrylamide) (PNiPAM) microgels

Cited by 37 publications

References 17 publications

Soft Nanotechnology with Soft Nanoparticles

Soft Nanotechnology with Soft Nanoparticles

Microgels by Precipitation Polymerization: Synthesis, Characterization, and Functionalization

A comparative study on thermoresponsive magnetic nanohydrogels: role of surface-engineered magnetic nanoparticles

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