Influence of polyaspartic acid and phosphophoryn on octacalcium phosphate growth kinetics

Burke, Eileen M.; Guo, Yanbu; Colón, Luis A.; Rahima, Mohammed; Veis, Arthur; Nancollas, G.H.

doi:10.1016/s0927-7765(99)00084-3

Cited by 63 publications

(68 citation statements)

References 21 publications

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“…Nevertheless, the postulated, more efficient formation of b-sheets in the case of poly(aspartic acid) on OCP [65,70] supports the above claim that not only the concentration or the absolute number of adsorbed acid or phosphate groups is important for nucleation control. Much rather, the configuration and conformation of a given (macro)-molecule on a surface will also have to be considered as an additional parameter for mineralization control.…”

Section: Introductionmentioning

confidence: 62%

“…Burke et al have studied the growth kinetics of OCP in the presence of poly(aspartic acid) and phosphophoryn, a highly phosphorylated protein also rich in aspartic acid. [70] Phosphophoryn was found to be a less efficient growth inhibitor than poly(aspartic acid). This lower efficiency was assigned to the more efficient formation of b-sheets on the OCP crystal surface in the case of poly(aspartic acid).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, these data contradict experiments with phosphorylated proteins, where a high number of phosphoserine units in the proteins was found to strongly inhibit (instead of nucleate) CaP mineralization. [67,68,70,71,79] In an attempt to rationalize the inhibition by phosphorylated polymers, Füredi-Milhofer et al [65,66] describe the effects of phosphate-containing polypeptides, which can be viewed as an extension of the single-component poly(amino acid)s discussed so far, on CaP mineralization. Phosphophoryn and phosvitin (approximately 50 mol-% of phosphoserine residues, but only 7 mol-% of aspartic acid residues) both recognize the Ca-OPO-Ca-OPO chain motif which is part of the HA-layer of OCP.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Polymer‐Controlled, Bio‐Inspired Calcium Phosphate Mineralization from Aqueous Solution

Schweizer

Taubert

2007

Macromolecular Bioscience

102

111

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Nowadays, the majority of the commercially available calcium phosphate materials is fabricated by 'classical' materials science approaches, i.e., from rather poorly defined slurries or from organic solvents, often at high temperatures and pressures. Bioinspired precipitation of inorganics with (polymeric) additives from aqueous solution, on the other hand, enables the synthesis of intriguing inorganic or organic/inorganic materials that are often much more closely related to biological structures. This article discusses approaches for the fabrication of bio-inspired calcium phosphate hybrid materials by precipitation from aqueous solution. The article focuses on polymers and related self-assembling structures for the design of CaP/organic hybrids and pure CaP with crystal structures and morphologies regulated by the respective additive.

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Section: Introductionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Polymer‐Controlled, Bio‐Inspired Calcium Phosphate Mineralization from Aqueous Solution

Schweizer

Taubert

2007

Macromolecular Bioscience

102

111

View full text Add to dashboard Cite

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“…It is produced without any environmental pollution and can be degraded completely by microbes and epiphytes after being used [3][4][5][6] . In China, people have performed relevant researches and published many papers, in which PASP was reported as a good substitute of other conventional scale inhibitors and a kind of valuable green scale inhibitor [7][8][9][10][11][12][13] .…”

Section: Static and Dynamic Experiments Were Carried Out To Validate mentioning

confidence: 99%

Experimental study on scale inhibition performance of a green scale inhibitor polyaspartic acid

Quan

Chen

Wang

et al. 2008

Sci. China Ser. B-Chem.

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Static and dynamic experiments were carried out to validate scale inhibition performance of a green scale inhibitor-polyaspartic acid (PASP). From the static experiment, it was shown that below 60℃, polyaspartic acid is very effective in scale inhibition, with the scale inhibition ratio exceeding 90% with only 3 mg/L PASP for the 600 mg/L hardness solution. For a higher hardness solution of 800 mg/L, the scale inhibition ratio can also reach 90% with 6 and 12 mg/L PASP at 30 and 60℃respectively. The SEM photographs of CaCO 3 crystals indicate that the crystal structure transforms from a compact stick-shape to a loose shape so that the scale can be washed away easily instead of being deposited on the heat transfer surface. The dynamic experimental results show that almost no scales formed on the heat transfer surface and the fouling thermal resistance decreases extraordinarily if PASP is added in the solution.polyaspartic acid, scale inhibition, fouling resistanceIn cooling water systems of industry, mineral ions in water, such as bicarbonate and calcium, may concentrate to form scale in heat transfer equipment, for example, heat exchangers, evaporators, condensers etc. The scale not only degrades performance of heat exchangers by increasing the resistance to heat transfer, but also wastes energy due to increasing power of pumps, resulting in tremendous economic loss. In order to control scale, numerous chemicals have been used widely in the cooling water systems. With the increase of environmental awareness, people pay much more attention to the study of new green scale inhibitors all over the world [1,2] .A green scale inhibitor named polyaspartic acid (PASP) without phosphorus was developed in the nineties. It is produced without any environmental pollution and can be degraded completely by microbes and epiphytes after being used [3][4][5][6] . In China, people have performed relevant researches and published many papers, in which PASP was reported as a good substitute of other conventional scale inhibitors and a kind of valuable green scale inhibitor [7][8][9][10][11][12][13] . However, most of the studies focused on the chemical syntheses of PASP rather than its scale inhibition performance. Experimental data of the scale inhibitor are not enough to validate its performance of scale inhibition. In addition, the static method is usually used to estimate the scale inhibition behavior, but it does not involve dynamic influence. The dynamic method is regarded as a credible evaluating method because of its simulating actual fouling processes of heat exchangers more factually [14] . In this paper, static and dynamic experiments were conducted to study the scale inhibition performance of PASP for the further application of PASP in industrial circulating water systems.

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“…[25] Burke et al reported that the phosphophoryn was found to be a less efficient growth inhibitor for OCP mineralization than poly(Asp), because the poly(Asp) frequently forms the b-sheet conformation on the OCP crystal surfaces. [26] These studies suggested that the acidic polypeptides, such as the poly(Asp) and phosphorylated proteins, inhibit the calcium phosphate nucleation and crystallization in the aqueous solution medium.…”

Section: Wide-angle X-ray Diffraction Analysismentioning

confidence: 99%

Calcium Phosphate Crystallization on Electrospun Cellulose Non‐Woven Fabrics Containing Synthetic Phosphorylated Polypeptides

Hayashi

Ohkawa

Yamamoto

et al. 2009

Macro Materials & Eng

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The preparation of electrospun non‐woven fabrics composed of cellulose and synthetic phosphorylated polypeptides, copoly[Ser(PO3H2)XAspY]s (X:Y = 100:0, 75:25, 50:50, 25:75), is described. The non‐wovens were subjected to an alternate immersion in CaCl2 and Na2HPO4 solutions to induce crystallization of calcium phosphate. The deposited calcium phosphate crystals were analyzed by means of EDX analysis and WXRD. The amounts of calcium phosphate deposition are greater for the cellulose non‐woven fabrics containing copoly[Ser(PO3H2)XAspY] than those of cellulose‐only non‐woven fabrics. These results indicate that copoly[Ser(PO3H2)XAspY] can entrap Ca2+ ions around the fine fiber matrix to accelerate crystallization of the calcium phosphate.magnified image

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Influence of polyaspartic acid and phosphophoryn on octacalcium phosphate growth kinetics

Cited by 63 publications

References 21 publications

Polymer‐Controlled, Bio‐Inspired Calcium Phosphate Mineralization from Aqueous Solution

Polymer‐Controlled, Bio‐Inspired Calcium Phosphate Mineralization from Aqueous Solution

Experimental study on scale inhibition performance of a green scale inhibitor polyaspartic acid

Calcium Phosphate Crystallization on Electrospun Cellulose Non‐Woven Fabrics Containing Synthetic Phosphorylated Polypeptides

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