Influence of Pluronic F127 microenvironments on the photochemical nitric oxide release from S-nitrosoglutathione

Picheth, Guilherme Fadel; Marini, Thatiane Cristine Camargo; Taladriz‐Blanco, Patricia; Shimamoto, Gustavo G.; Santos, Giovanna Jardim Vieira P. dos; Meneau, Florian; Oliveira, Marcelo Ganzarolli de

doi:10.1016/j.jcis.2019.02.087

Cited by 22 publications

(8 citation statements)

References 67 publications

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“…The thermal behavior of the SR-SD and SR-DA was evaluated by DSC. 28 An empty aluminum pan was used as a reference. Temperature scans were performed in an aluminum sample port from 0 to 70.0 °C, at a rate of 2.0 °C min −1 with compressed air flow.…”

Section: Methodsmentioning

confidence: 99%

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

Silva-Junior

Campanholi

Morais

et al. 2020

ACS Appl. Bio Mater.

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Safranine-O (Sf) is a photosensitizer (PS) displaying a remarkable potential for photodynamic therapy (PDT). In this work, we have used the combination of Sf with F127 Pluronic and Carbopol (C934P) to obtain a stimuliresponsive hydrogel (SR-Sf). This thermoresponsive-photoactive nanostructured system was prepared by two different methods: direct addition (DA) and solid dispersion (SD). Both SR-Sf have had their physical and chemical properties evaluated for veterinary applications, especially considering their ability to be used as a commercial product, aiming at the prophylactic or therapeutic treatment of breast gland infections. In general, the rheological and mechanical properties, as well as the sol−gel transition temperature, indicated suitable properties for using them as a topical system in veterinary (and human) applications. The ex vivo release studies showed a satisfactory permeation profile of the SR-Sf hydrogel, reaching the full length of the overall skin toward the dermis within 30 min of application (989 μm). The in vitro studies showed photodynamic inactivation using Sf-F127 with a significant reduction in isolated colonies. The in vivo case report with dairy goat demonstrated that the SR-Sf hydrogel veterinary use platform emerged as an innovative approach for the treatment of local infections without generating antibiotic residues in the milk produced.

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Section: Methodsmentioning

confidence: 99%

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

Silva-Junior

Campanholi

Morais

et al. 2020

ACS Appl. Bio Mater.

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“…as the relative amount of one component to the other is changed 45 – 47 . Reports show that with the increase of SC concentration, the core of the micelles formed with Pluronic F127 becomes more hydrophobic, therefore their corona becomes more hydrophilic 48 , 49 . These insights are in accordance with our observations detailed above.…”

Section: Resultsmentioning

confidence: 99%

En route to single-step, two-phase purification of carbon nanotubes facilitated by high-throughput spectroscopy

Podlesny

Olszewska

Yaari

et al. 2021

Sci Rep

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Chirality purification of single-walled carbon nanotubes (SWCNTs) is desirable for applications in many fields, but general utility is currently hampered by low throughput. We discovered a method to obtain single-chirality SWCNT enrichment by the aqueous two-phase extraction (ATPE) method in a single step. To achieve appropriate resolution, a biphasic system of non-ionic tri-block copolymer surfactant is varied with an ionic surfactant. A nearly-monochiral fraction of SWCNTs can then be harvested from the top phase. We also found, via high-throughput, near-infrared excitation-emission photoluminescence spectroscopy, that the parameter space of ATPE can be mapped to probe the mechanics of the separation process. Finally, we found that optimized conditions can be used for sorting of SWCNTs wrapped with ssDNA as well. Elimination of the need for surfactant exchange and simplicity of the separation process make the approach promising for high-yield generation of purified single-chirality SWCNT preparations.

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“…A total of 8.02% and 28.98% of the NO were released in the first 4 h and 12 h, respectively, followed by a sustained release of 71.2% over 7 days. Previous reports state that the incorporation of GSNO into the hydrogel can decrease the rates of the NO release, with the decrease resulting from the cage effect promoted by the higher viscosity of the hydrogel matrix [ 44 , 45 ]. GSNO-PL/AL hydrogel is a physical gel.…”

Section: Resultsmentioning

confidence: 99%

Nitric Oxide-Releasing Thermoresponsive Pluronic F127/Alginate Hydrogel for Enhanced Antibacterial Activity and Accelerated Healing of Infected Wounds

et al. 2020

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Nitric oxide (NO), a highly reactive and lipophilic molecule, is one of the molecules present in the wound environment and implicated as an important regulator in all phases of wound healing. Here, we developed an NO-releasing thermoresponsive hydrogel (GSNO-PL/AL) composed of S-nitrosoglutathione (GSNO), pluronic F127 (PL), and alginate (AL) for the treatment of infected wounds. The GSNO was incorporated into the thermoresponsive PL/AL hydrogel, and differential scanning calorimetry techniques were used for the hydrogel characterization. The hydrogel was assessed by in vitro NO release, antibacterial activity, cytotoxicity, and wound-healing activity. The GSNO-PL/AL hydrogel demonstrated thermal responsiveness and biocompatibility, and it showed sustained NO release for 7 days. It also exhibited potent bactericidal activity against Gram-positive methicillin-resistant Staphylococcus aureus and Gram-negative multidrug-resistant Pseudomonas aeruginosa (MRPA). Moreover, the GSNO-PL/AL treatment of MRPA-infected wounds accelerated healing with a reduced bacterial burden in the wounds. The GSNO-PL/AL hydrogel would be a promising option for the treatment of infected wounds.

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Influence of Pluronic F127 microenvironments on the photochemical nitric oxide release from S-nitrosoglutathione

Cited by 22 publications

References 67 publications

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

Photothermal Stimuli-Responsive Hydrogel Containing Safranine for Mastitis Treatment in Veterinary Using Phototherapy

En route to single-step, two-phase purification of carbon nanotubes facilitated by high-throughput spectroscopy

Nitric Oxide-Releasing Thermoresponsive Pluronic F127/Alginate Hydrogel for Enhanced Antibacterial Activity and Accelerated Healing of Infected Wounds

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