Influence of Plasma Lipid Composition on Activity of Factors V, VII and X in Single Comb White Leghorn and Fatty Liver Haemorrhagic Syndrome-Susceptible Laying Hens

Abstract

1. Plasma lipids were investigated to determine whether they influence the biological activities of specific coagulation proteins Factors V, VII and X. 2. Factor activities decreased when lipids were depleted from the plasma of Single Comb White Leghorn (SCWL) and Fatty Liver Haemorrhagic Syndrome-susceptible (FLHS) laying hens. 3. Addition of lipids removed from SCWL laying hens and FLHS-susceptible laying hens into lipid-depleted plasma of both bird strains caused an increase and decrease, respectively, in Factors V and X activities. 4. Omega-3 fatty acids were negatively correlated to Factors V, VII and X activities. When bird strain was considered, it was significant for Factor X in SCWL laying hens. Omega-6 fatty acids were positively correlated with Factors VII and X for FLHS-susceptible laying hens. 5. The results suggest that the type of fatty acid in plasma phospholipids influences the activities of Factors V, VII and X and by altering lipid composition in the plasma, activities of coagulation factors may be affected.

A Pilot Study of Tissue Factor-Tissue Factor Pathway Inhibitor Axis and Other Selected Coagulation Parameters in Broiler Chickens Administered in Ovo with Selected Prebiotics

“…Despite the crucial role of TF and TFPI in the coagulation process, their exact functions and blood levels in poultry have never been reported. This issue may be exceptionally important in view of the fact that hemostatic disturbances are a growing and significant problem in poultry production (MURAMOTO et al 2006;YEH et al 2008;YEH et al 2009;NAZIFI et al 2010;PLISZCZAK-KROL et al 2012;ZERYEHUN et al 2012;WIDEMAN et al 2013). Several cases of disseminated intravascular coagulation in birds caused by pathogens and tranexamic acid have been reported recently (SHI- BATANI et al 1997;MURAMOTO et al 2006;MORIS 2015;SUBA et al 2015).…”