Influence of plant and environment parameters on phytochemical composition and biological properties of Pistacia atlantica Desf.

Benmahieddine, Assia; Belyagoubi-Benhammou, Nabila; Belyagoubi, Larbi; Zerey-Belaskri, Asma El; Gismondi, Angelo; Marco, Gabriele Di; Canini, Antonella; Bechlaghem, Nadjat; Bekkara, Fawzia Atik; Djebli, Noureddine

doi:10.1016/j.bse.2021.104231

Cited by 18 publications

(18 citation statements)

References 39 publications

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“…The DPPH radical scavenging activity of the different extracts is positively correlated with the TPC in the extracts. These results of DPPH • scavenging are higher than previous studies by Benmahieddine and Hatamnia [ 34 , 42 ], which estimated the value in the range of (IC 50 : 38–2390 μg/mL). Moreover, when comparing the performance of region TRC3 with other extracts, it found that all aqueous extracts showed strong antioxidant potential utilizing DPPH radical scavenging activity, but were reported to be lower than our results [ 42 , 43 ].…”

Section: Discussioncontrasting

confidence: 76%

“…The main observation from the results is that all studied samples contained a large amount of phenolic content. Based on these results found, the data obtained were higher than the results obtained in a study conducted by Benmahieddine et al [ 34 ], who observed that the degree of fruit ripening affected the amount of phenols in the range of 10.11–64.14 mg/g. The study conducted by Belyagoubi, L [ 35 ], found that the solvents used for extraction influenced the phenolic content of ripe fruits, in the range of 2.30–31.86 mg/g.…”

Section: Discussioncontrasting

confidence: 68%

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Mineral Profile, Antioxidant, Anti-Inflammatory, Antibacterial, Anti-Urease and Anti-α-Amylase Activities of the Unripe Fruit Extracts of Pistacia atlantica

et al. 2023

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Pistacia Atlantica in folk medicine is used by Algerian traditional healers for treating a wide variety of diseases and conditions including dyspepsia, digestive problems, peptic ulcers, and, in particular, inflammatory diseases. The present study aimed to assess the phytochemical composition, in vitro antioxidant activity (using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS+, and reducing power methods), enzyme inhibitory activity (towards α-amylase and urease), antibacterial activity, and in vivo anti-inflammatory activity of the unripe fruit extracts of Pistacia atlantica collected from different parts of the Djelfa region of Algeria. According to the findings, various aqueous extracts exhibited significant antioxidant and enzymatic activities in all tests, but showed that they have a weak inhibitory effect against all tested bacterial strains. Twenty-one minerals comprising both macro- and microelements (Ba, Br, Ca, Cl, Co, Cr, Cs, Eu, Fe, K, Mg, Mn, Mo, Na, Rb, Sb, Sc, Sr, Th, U, and Zn) were determined using the technique of neutron activation analysis (INAA). The result indicates that the concentration of the mineral element is close to the minimal FAO recommendation. In addition, the result revealed significant anti-inflammatory activities. The data generated can be a valuable source of information for the pharmaceutical industry and medical research. These results suggest that the unripe fruit extracts of Pistacia atlantica have an appropriate potential to be utilized across a wide range of contexts as an agent with multifunctional uses, as well as a natural remedy for other physiological diseases.

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Section: Discussioncontrasting

confidence: 76%

Section: Discussioncontrasting

confidence: 68%

Mineral Profile, Antioxidant, Anti-Inflammatory, Antibacterial, Anti-Urease and Anti-α-Amylase Activities of the Unripe Fruit Extracts of Pistacia atlantica

et al. 2023

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“…Comparing the results with the works of other authors, for example, oak extracts obtained with water, the TPC varies in the range from 0.3-0.4 GAE g/g, while the water extracts from black alder bark contain more TPC, 0.56-0.63 GAE g/g [19], and the obtained values of antioxidant activity are also high compared with the extracts obtained from the different plants and their different parts of plants [20]. The methanol extract from pistachios shows a high TPC of 0.56 GAE g/g with a relatively high antioxidant activity, but it should be noted that it is obtained with a volatile organic solvent extraction agent that is not environmentally friendly [21]. As shown by Charu et al [22], from Hungarian black alder bark using different solvents the authors have obtained extracts with much lower results in terms of the total polyphenol content, 21.25 and 15.14 GAE mg/g in 80% ethanol water and in 80% acetone water extracts, respectively.…”

Section: Resultsmentioning

confidence: 87%

Antioxidant Activity of Different Extracts from Black Alder (Alnus glutinosa) Bark with Greener Extraction Alternative

Lauberts

Pāls

2021

Plants

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Phenolic compounds isolated from plant biomass consist of bioactive components showing a wide range of benefits for humans, including antioxidant, antimicrobial or anti-inflammatory effects. This paper presents the potential value of black alder (Alnus glutinosa (L.) Gaertn. (Betulaceae)) bark for the production of biologically active substances, despite its current use as a low value fuel source. Most of the extraction methods employ neat organic solvents to obtain extracts with a high antioxidant potential from biomass. The aim of this work is to show the advantages and disadvantages of the extraction process by taking into account the principles of ‘green chemistry’ and replacing the organic solvents with ‘green’ solvent water. Using the advantages of accelerated solvent extraction (ASE), it has been shown that the use of deionized water has the prospect of replacing organic solvents. In the case of the one-step water extraction, the total polyphenol content (TPC) varies from 0.55 to 0.62 Gallic acid equivalent (GAE) g/g in the extracts, depending on the temperature, whereas with the result of the sequential extraction with the organic solvents, the TPC content of the 40% (v:v) ethanol extracts ranges from 0.39 to 0.61 GAE g/g, depending on the temperature. The influence of the total polyphenol content and the total proanthocyanidin content on the antioxidant activity is shown. The antioxidant activity (IC50, mg/L) of the extracts obtained with the organic solvents in the (2,2-diphenyl-1-picrylhydrazyl) DPPH• test varies from 4.05 to 9.58, depending on the temperature in the range of 70–150 °C, respectively, while the results obtained with the deionized water showed promising results in the range of 6.33–7.36 in the temperature range of 70–150 °C, respectively. The extraction with the deionized water showed that approximately 90% of the substances in the extracts obtained with the organic solvents by sequential extraction are possible to obtain as deionized water extracts.

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“…Numerous studies have been conducted to demonstrate the wide range of pharmacological activities at the expense of P. atlantica , including antibacterial [ 10 , 11 , 12 ], antioxidant [ 11 , 12 , 13 , 14 ], antidiabetic [ 14 , 15 , 16 ], anti-inflammatory [ 12 , 17 ], hepatoprotective [ 18 ], antitumor [ 19 , 20 ], anti-acetylcholinesterase [ 21 , 22 ], and antihyperlipidemic effects [ 23 ]. In fact, there are various chemical compounds in this plant species that may justify its potential therapeutic role, including triterpenoids, flavonoids, other phenolic compounds, tannins, fatty acids, and phytosterols [ 4 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Nutraceutical Content and Biological Properties of Lipophilic and Hydrophilic Fractions of the Phytocomplex from Pistacia atlantica Desf. Buds, Roots, and Fruits

Belyagoubi-Benhammou,

Belyagoubi,

Benmahieddine

et al. 2024

Plants

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The aim of the present investigation was to obtain 12 aqueous extracts and 1 oil from Pistacia atlantica Desf. subsp. atlantica specimens. The samples differed for processed plant organs (i.e., roots, buds, and fruits), gender and geographical station of the collected trees. Total phenols, flavonoids, and condensed tannins were determined, revealing that bud extracts exhibited the highest phenolic content (386.785 ± 16.227 mg GAE/g DM), followed by fruit and root preparations. Similar results were detected for flavonoids and tannins, whose quantitation ranged from 0.014 ± 0.005 to 74.780 ± 9.724 mg CE/g DM and from 0.037 ± 0.003 to 14.793 ± 0.821 mg CE/g DM, respectively. The biochemical profile of the extracts was further characterized by HPLC-DAD, in terms of specific phenolics. This analysis identified gallic acid as a typical metabolite for ripe fruit, while hydroxytyrosol for female roots and male buds. In parallel, P. atlantica fruit oil was profiled by GC-MS analysis, which detected 37 lipophilic components, including palmitic acid (the major component, ~55%), anacardol, tetradecanol, arachidic acid, squalene, and some terpenes. The samples revealed interesting antioxidant activity, with EC50 values ranging from 0.073 ± 0.001 to 193.594 ± 28.942 mg/mL and from 0.029 ± 0.001 to 103.086 ± 20.540 mg/mL, in that order, for DPPH and reducing power assays. Concerning the total antioxidant capacity, the results ranged from 0.053 ± 0.008 to 51.648 ± 1.659 mg AAE/g DM. Finally, the antimicrobial potential of the plant extracts was estimated against 7 bacterial species and 2 fungal strains, known to be human pathogens, demonstrating a good antibiotic effect for the bud extracts. All these findings strongly suggest that P. atlantica would represent a natural reservoir for novel additives to be used in therapeutic, food, and cosmetic products.

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Influence of plant and environment parameters on phytochemical composition and biological properties of Pistacia atlantica Desf.

Cited by 18 publications

References 39 publications

Mineral Profile, Antioxidant, Anti-Inflammatory, Antibacterial, Anti-Urease and Anti-α-Amylase Activities of the Unripe Fruit Extracts of Pistacia atlantica

Mineral Profile, Antioxidant, Anti-Inflammatory, Antibacterial, Anti-Urease and Anti-α-Amylase Activities of the Unripe Fruit Extracts of Pistacia atlantica

Antioxidant Activity of Different Extracts from Black Alder (Alnus glutinosa) Bark with Greener Extraction Alternative

Nutraceutical Content and Biological Properties of Lipophilic and Hydrophilic Fractions of the Phytocomplex from Pistacia atlantica Desf. Buds, Roots, and Fruits

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