“…Autoregulation of adrenocorticotropic hormone (ACTH) was first suggested by the observations of Gemzell and Heijkenskjold (30), Kitay, Holub, and Jailer (31), and Hodges and Vernikos (32). Characterization of this type of control mechanism for ACTH was described by Motta, Mangili, and Martini in 1965 (33 (40) and, in man, after pituitary stalk section (41,42) or hypothalamic disease (43,44). Also, microinjection of glucose into the hypothalamus, coincident with systemic hypoglycemia, prevents the normal GH response to hypoglycemia (45).…”