Influence of Piper betle on hepatic marker enzymes and tissue antioxidant status in D-galactosamine-induced hepatotoxic rats

Pushpavalli, Ganesan; Veeramani, Chinnadurai; Pugalendi, Kodukkur Viswanathan

doi:10.1515/jbcpp.2008.19.2.131

Cited by 13 publications

(7 citation statements)

References 27 publications

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“…In the literature, several antioxidants have been investigated for their effects in preventing furan-induced toxicity in different organs and tissues (19, 21, 36, 41, 42). Augmented antioxidant capacity is critical in providing a hepatoprotective effect and counteracts the untoward effects of oxidative stress (35). Our literature review revealed no studies investigating the antioxidant effects of propolis treatment in the furan-induced hepatotoxicity model in rats.…”

Section: Discussionmentioning

confidence: 99%

Protective role of propolis on low and high dose furan-induced hepatotoxicity and oxidative stress in rats

Kaya

Yılmaz

Çeribaşı

2019

Journal of Veterinary Research

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Introduction The aim of this study was to evaluate potential protective effects of propolis on furan-induced hepatic damage by assessing the levels of malondialdehyde (MDA) and reduced glutathione (GSH), antioxidant enzyme activities, and histopathological changes in the liver. Material and Methods Albino Wistar rats were divided into six groups: a control, propolis-treated (100 mg/kg b.w./day), low-dose furan-treated (furan-L group; 2 mg/kg b.w./day), high-dose furan-treated (furan-H group; 16 mg/kg b.w./day), furan-L+propolis treated, and furan-H+propolis treated group. Propolis and furan were applied by gavage; propolis for 8 days, and furan for 20 days in furan-L groups and 10 days in furan-H groups. ResultsWhile MDA levels were elevated in furan-treated groups, levels of GSH and activities of antioxidant enzymes decreased (p < 0.001). The levels of MDA and GSH and activities of antioxidant enzymes were normal in the furan+propolis groups, especially in the furan-L+propolis group (p < 0.001). While the aspartate transaminase, alanine transaminase, alkaline phosphatase, and lactate pdehydrogenase activities were elevated in the furan-H treated group (p < 0.05 and p < 0.001), they were unchanged in the furan-L treated group. Histopathologically, several lesions were observed in the liver tissues of the furan-treated groups, especially in the higher-dose group. It was determined that these changes were milder in both of the furan+propolis groups. Conclusion The results indicate that propolis exhibits good hepatoprotective and antioxidant potential against furan-induced hepatocellular damage in rats.

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Section: Discussionmentioning

confidence: 99%

Protective role of propolis on low and high dose furan-induced hepatotoxicity and oxidative stress in rats

Kaya

Yılmaz

Çeribaşı

2019

Journal of Veterinary Research

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“…PB was reported to possess hepatoprotective action. Studies examined the effect of PB on various toxic compounds including cadmium, carbon-tetrachloride, D-galactosamine, and ethanol which showed PB extract significantly reduced liver injury caused by the toxic compounds [13][14][15][16]. PB extract exhibited high antioxidant activities [21].…”

Section: Discussionmentioning

confidence: 99%

“…Numerous scientific studies reported therapeutic properties of PB [11,12]. PB was reported to exhibit hepatoprotective effect against various toxic insults including cadmium, carbon tetrachloride, ethanol, and D-galactosamine [13][14][15][16]. Hence, in the present study, we aimed to observe the effect of PB in hepatotoxicity caused by MS.…”

Section: Introductionmentioning

confidence: 98%

Mitragyna Speciosa-Induced Hepatotoxicity-Treated Effectively by Piper Betle: Scope as a Future Antidote

Haslan

Suhaimi

Das

2018

Asian J Pharm Clin Res

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Objective: Consumption of Mitragyna speciosa (MS) leads to various toxicities including hepatotoxicity. Piper betle (PB) is a herb that possesses various therapeutic properties. The aim of the present study was to examine the protective effect of PB methanol extract (PBME) on MS-induced hepatotoxicity which could pave the way for any future antidote.Methods: Twenty-four male Sprague–Dawley rats were randomized into control and experimental groups. The control group was further divided into the negative (G-T80) and positive (G-PB) control groups. The G-T80 group (n=6) received oral gavage of the vehicle, 15% Tween 80. The G-PB group (n=6) received PBME 200 mg/kg/day, orally. The experimental group was divided into two groups, i.e., The G-MS and G-MS (PB) groups. The G-MS group (n=6) received only MS methanol extract (MSME) 500 mg/kg/day, while the G-MS (PB) group (n=6) received MSME with concomitant treatment with PBME.Results: Histopathology examination of the G-T80 and G-PB groups showed normal histology of the liver. The G-MS group showed liver injury features such as microvesicular steatosis, ballooning degeneration, acidophilic bodies, scattered focal necrosis, fibrous portal expansion, bridging fibrosis, sinusoidal congestion, and dilatation. These features were fewer in the G-MS (PB) group which received concomitant treatment with PBME.Conclusion: Administration of PBME exerted a protective effect against MS-induced hepatotoxicity. Future clinical trials using PB as an antidote may help in combating MS-induced hepatoxicity.

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“…The extract at a dose of 200 mg/kg bw improved antioxidant levels such as lipid hydroperoxidase (LOOH), SOD, GSH, GSH peroxidise, vitamin E and vitamin C,decreased TBARS, hydroperoxidase and liver marker enzymes such as ALT, AST, alkaline phosphate (ALP) and gamma glutamyl transpeptidase (GGTP). 139 To evaluate the hepatoprotective activity of P . betle , Young et al induced liver fibrosis with carbon tetrachloride (CCl 4 ) and corn oil in Wistar rats.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

Biswas

Anand

Saha

et al. 2022

J Cellular Molecular Medi

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Piper betle L. (synonym: Piper betel Blanco), or betel vine, an economically and medicinally important cash crop, belongs to the family Piperaceae, often known as the green gold. The plant can be found all over the world and is cultivatedprimarily in South East Asian countries for its beautiful glossy heart‐shaped leaves, which are chewed or consumed as betelquidand widely used in Chinese and Indian folk medicine, as carminative, stimulant,astringent, against parasitic worms, conjunctivitis, rheumatism, wound, etc., andis also used for religious purposes. Hydroxychavicol is the most important bioactive compound among the wide range of phytoconstituents found in essential oil and extracts. The pharmacological attributes of P . betle are antiproliferation, anticancer, neuropharmacological, analgesic, antioxidant, antiulcerogenic, hepatoprotective, antifertility, antibacterial, antifungal and many more. Immense attention has been paid to nanoformulations and their applications. The application of P . betle did not show cytotoxicity in preclinical experiments, suggesting that it could serve as a promising therapeutic candidate for different diseases. The present review comprehensively summarizes the botanical description, geographical distribution, economic value and cultivation, ethnobotanical uses, preclinical pharmacological properties with insights of toxicological, clinical efficacy, and safety of P . betle . The findings suggest that P . betle represents an orally active and safe natural agent that exhibits great therapeutic potential for managing various human medical conditions. However, further research is needed to elucidate its underlying molecular mechanisms of action, clinical aspects, structure–activity relationships, bioavailability and synergistic interactions with other drugs.

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Influence of Piper betle on hepatic marker enzymes and tissue antioxidant status in D-galactosamine-induced hepatotoxic rats

Cited by 13 publications

References 27 publications

Protective role of propolis on low and high dose furan-induced hepatotoxicity and oxidative stress in rats

Protective role of propolis on low and high dose furan-induced hepatotoxicity and oxidative stress in rats

Mitragyna Speciosa-Induced Hepatotoxicity-Treated Effectively by Piper Betle: Scope as a Future Antidote

Betelvine (Piper betleL.): A comprehensive insight into its ethnopharmacology, phytochemistry, and pharmacological, biomedical and therapeutic attributes

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