Influence of pinealectomy on the amygdala kindling development in rats

Janjoppi, Luciana; Lacerda, Aline Fabiana Silva de; Amado, Débora; Cavalheiro, Ésper A.; Arida, Ricardo Mário

doi:10.1016/j.neulet.2005.09.009

Cited by 15 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, in the model of pilocarpine induced seizures in rats, pinealectomy was also found to be associated with reduced time needed to first spontaneous seizures and further even increased number of spontaneous recurrent seizures during the chronic phase [ 79 ]. These findings together confirm the neuroprotective role of melatonin, both endogenous and exogenous [ 136 ].…”

Section: Antiepileptic Therapy and Oxidative Stresssupporting

confidence: 79%

“…Melatonin was reported to suppress generalized seizures in amygdala kindled rats [ 75 ]. It is also known that pineal- ectomy reduces the number of stimulations required to trigger amygdala kindling [ 136 ]. Similarly, in the model of pilocarpine induced seizures in rats, pinealectomy was also found to be associated with reduced time needed to first spontaneous seizures and further even increased number of spontaneous recurrent seizures during the chronic phase [ 79 ].…”

Section: Antiepileptic Therapy and Oxidative Stressmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Martinc¹,

Grabnar²,

Vovk

2015

View full text Add to dashboard Cite

Epilepsy is known as one of the most frequent neurological diseases, characterized by an enduring predisposition to generate epileptic seizures. Oxidative stress is believed to directly participate in pathways leading to neurodegeneration, which serves as the most important propagating factor, leading to the epileptic condition and cognitive decline. Moreover, there is also a growing body of evidence showing the disturbance of antioxidant system balance and consequently increased production of reactive species in patients with epilepsy. A meta-analysis, conducted in the present review confirms an association between epilepsy and increased lipid peroxidation. Furthermore, it was also shown that some of the antiepileptic drugs could potentially be responsible for additionally increased lipid peroxidation. Therefore, it is reasonable to propose that during the epileptic process neuroprotective treatment with antioxidants could lead to less sever structural damages, reduced epileptogenesis and milder cognitive deterioration. To evaluate this hypothesis studies investigating the neuroprotective therapeutic potential of various antioxidants in cells, animal seizure models and patients with epilepsy have been reviewed. Numerous beneficial effects of antioxidants on oxidative stress markers and in some cases also neuroprotective effects were observed in animal seizure models. However, despite these encouraging results, till now only a few antioxidants have been further applied to patients with epilepsy as an add-on therapy. Based on the several positive findings in animal models, a strong need for more carefully planned, randomized, double-blind, cross-over, placebo-controlled clinical trials for the evaluation of antioxidants efficacy in patients with epilepsy is warranted.

show abstract

Section: Antiepileptic Therapy and Oxidative Stresssupporting

confidence: 79%

Section: Antiepileptic Therapy and Oxidative Stressmentioning

confidence: 99%

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Martinc¹,

Grabnar²,

Vovk

2015

View full text Add to dashboard Cite

show abstract

“…Pinealectomy (pineal gland removal), seemed to accelerate the amygdala kindling process by reducing the number of stimulations needed to reach fully kindled stage [515], suggesting that endogenous melatonin may act as a neuroprotective factor, as it was observed at pinealectomized epileptic rats, after SE induction in the pilocarpine model [516].…”

Section: Melatonin and Melatonin Receptors In Epilepsymentioning

confidence: 95%

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Zavala-Tecuapetla

Cuéllar-Herrera

Luna-Munguía

2020

IJMS

View full text Add to dashboard Cite

Epilepsy is a chronic brain disease that affects approximately 65 million people worldwide. However, despite the continuous development of antiepileptic drugs, over 30% patients with epilepsy progress to drug-resistant epilepsy. For this reason, it is a high priority objective in preclinical research to find novel therapeutic targets and to develop effective drugs that prevent or reverse the molecular mechanisms underlying epilepsy progression. Among these potential therapeutic targets, we highlight currently available information involving signaling pathways (Wnt/β-catenin, Mammalian Target of Rapamycin (mTOR) signaling and zinc signaling), enzymes (carbonic anhydrase), proteins (erythropoietin, copine 6 and complement system), channels (Transient Receptor Potential Vanilloid Type 1 (TRPV1) channel) and receptors (galanin and melatonin receptors). All of them have demonstrated a certain degree of efficacy not only in controlling seizures but also in displaying neuroprotective activity and in modifying the progression of epilepsy. Although some research with these specific targets has been done in relation with epilepsy, they have not been fully explored as potential therapeutic targets that could help address the unsolved issue of drug-resistant epilepsy and develop new antiseizure therapies for the treatment of epilepsy.

show abstract

“…Previous studies have shown that the removal of the pineal gland, which causes a substantial decrease in the plasma melatonin levels, increases the seizure threshold, thereby facilitates the development of epileptogenic processes in different seizure models [ 12 , 13 , 14 ]. Pinealectomy shortens the latent seizure-free period in the pilocarpine model of temporal lobe epilepsy [ 12 ], reduces the number of electrical stimulations of amygdala required for kindling development [ 13 ], and decreases the latency of initial epileptiform discharges in the penicillin model of focal epilepsy [ 14 ]. In addition, pinealectomy exacerbates pilocarpine-induced neuronal death and mossy fiber sprouting in the hippocampus [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats?

Moyanova

Fusco

Santolini

et al. 2018

IJMS

View full text Add to dashboard Cite

Absence epilepsy and depression are comorbid disorders, but the molecular link between the two disorders is unknown. Here, we examined the role of the melatoninergic system in the pathophysiology of spike and wave discharges (SWDs) and depression-like behaviour in the Wistar Albino Glaxo from Rijswijk (WAG/Rij) rat model of absence epilepsy. In WAG/Rij rats, SWD incidence was higher during the dark period of the light-dark cycle, in agreement with previous findings. However, neither pinealectomy nor melatonin administration had any effect on SWD incidence, suggesting that the melatoninergic system was not involved in the pathophysiology of absence-like seizures. Endogenous melatonin levels were lower in the hippocampus of WAG/Rij rats as compared to non-epileptic control rats, and this was associated with higher levels of melatonin receptors in the hippocampus, but not in the thalamus. In line with the reduced melatonin levels, cell density was lower in the hippocampus of WAG/Rij rats and was further reduced by pinealectomy. As expected, WAG/Rij rats showed an increased depression-like behaviour in the sucrose preference and forced swim tests, as compared to non-epileptic controls. Pinealectomy abolished the difference between the two strains of rats by enhancing depression-like behaviour in non-epileptic controls. Melatonin replacement displayed a significant antidepressant-like effect in both WAG/Rij and control rats. These findings suggest that a defect of hippocampal melatoninergic system may be one of the mechanisms underlying the depression-like phenotype in WAG/Rij rats and that activation of melatonin receptors might represent a valuable strategy in the treatment of depression associated with absence epilepsy.

show abstract

Influence of pinealectomy on the amygdala kindling development in rats

Cited by 15 publications

References 19 publications

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Antioxidants as a Preventive Treatment for Epileptic Process: A Review of the Current Status

Insights into Potential Targets for Therapeutic Intervention in Epilepsy

Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and Depression-Like Behavior in WAG/Rij Rats?

Contact Info

Product

Resources

About