Influence of Photodynamic Therapy on Expression of Vascular Endothelial Growth Factor (VEGF), VEGF Receptor 3, and Pigment Epithelium–Derived Factor

Schmidt‐Erfurth, Ursula; Schlötzer-Schrehard, Ursula; Cursiefen, Claus; Michels, Stephan; Beckendorf, A.; Naumann, Gottfried O.H.

doi:10.1167/iovs.02-1115

Cited by 308 publications

(222 citation statements)

References 31 publications

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“…Similar to this study, the long-term outcomes of AMD after PDT have indicated several serious problems. For example, long-term influences of PDT, such as damage to the retinal pigment epithelium after PDT 21 and choroidal hypoperfusion (which is correlated with chorioretinal atrophy), 22 have been reported.…”

Section: Discussionmentioning

confidence: 99%

Long-term outcome of intravitreal ranibizumab treatment, compared with photodynamic therapy, in patients with polypoidal choroidal vasculopathy

Inoue

Arakawa

Yamane

et al. 2013

Eye

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Section: Discussionmentioning

confidence: 99%

Long-term outcome of intravitreal ranibizumab treatment, compared with photodynamic therapy, in patients with polypoidal choroidal vasculopathy

Inoue

Arakawa

Yamane

et al. 2013

Eye

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“…12 The surge of local angiogenic factors caused by choroidal hypoperfusion, persistent inflammation from CNV itself, and following treatment may also contribute to the high rate of recurrence. 13,14 Several studies have shown that PDT combined with intravitreal injection of the corticosteroid triamcinolone acetonide (IVTA) is more effective for treating CNV than PDT alone. [15][16][17][18][19] However, IVTA has been shown to produce side effects, such as cataract progression, elevated intraocular pressure (IOP), endophthalmitis, and retinal detachment.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy combined with posterior subtenon triamcinolone acetonide injection in the treatment of choroidal neovascularization

et al. 2008

Eye

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Purpose To evaluate the therapeutic effect of photodynamic therapy (PDT) combined with posterior subtenon injection of triamcinolone acetonide (PSTA) in the treatment of choroidal neovascularization (CNV). Methods In this retrospective case-control study, treatment outcomes at 12 months of patients with CNV were reviewed. One hundred and two consecutive patients (102 eyes) with subfoveal CNV of various causes were included. Patients in the study group (n ¼ 46) received PDT followed within 2 days by 40 mg of PSTA. Patients in the control group (n ¼ 56) received PDT alone. Patients were retreated 3 months later or more if fluorescein angiography showed residual membrane leakage. Treatment outcomes were compared between the two groups and among different CNV subgroups. Results Gain in mean best-corrected visual acuity (BCVA) was significantly higher in the study group ( þ 0.78 lines) than in the control group (À1.86 lines) (Po0.0001). The number of treatments within 1 year was significantly less in the study group (1.26 vs 1.63, P ¼ 0.008). The mean BCVA change for myopic CNV and age-related predominantly classic CNV subgroups was significantly higher in the study group ( þ 2.82 vs À0.91 lines, P ¼ 0.0005 for myopic CNV; þ 0.6 vs À1.79 lines, P ¼ 0.01 for age-related predominantly classic CNV). The main side effect in the study group was increased intraocular pressure (8.7%). ConclusionCompared with PDT alone, PDT combined with PSTA has a better therapeutic effect for both myopic and age-related predominantly classic CNV; the myopic CNV subgroup shows the best response.

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“…Local release of VEGF occurs after PDT as well. 23 This could have a detrimental effect on the CNV process when inflammation is the main mechanism.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic therapy combined with systemic corticosteroids for choroidal neovascularisation secondary to punctate inner choroidopathy

Fong

Thomas

Amin

et al. 2007

Eye

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Aim To report on visual acuity (VA) and angiographic outcomes in patients presenting with subfoveal choroidal neovascular membranes (CNV) secondary to punctate inner choroidopathy (PIC), treated with photodynamic therapy (PDT) with verteporfin combined with systemic corticosteroids. Methods A prospective case series of patients with subfoveal CNV secondary to PIC was analysed. All patients were treated with PDT combined with oral prednisolone (1 mg/kg body weight/day) which was started 5 days before PDT. Fluorescein angiography was performed at baseline and every 3 months post-treatment to establish the size, position, and activity of the CNV. Visual acuity was measured using the ETDRS scale. Further PDT treatment was carried out at follow-up visits if there was angiographic evidence of ongoing CNV activity. Results Five female patients with a mean age of 30.4 years (range 25-43 years) were treated over a 12-month period. The mean greatest linear diameter (GLD) of the CNV was 1.66 mm (range 0.46-3.28 mm). A mean improvement in vision of nine ETDRS letters (range À15-20 letters) after treatment was found, which was maintained at final followup. The mean follow-up time was 12 months (range 10-14 months). The mean number of PDT treatments was two (range 1-3). Conclusions: The vaso-occlusive effect of PDT combined with the vasostatic and antiinflammatory effect of systemic oral prednisolone appears to be a safe and effective option in the primary treatment of subfoveal CNV in patients with PIC.

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Influence of Photodynamic Therapy on Expression of Vascular Endothelial Growth Factor (VEGF), VEGF Receptor 3, and Pigment Epithelium–Derived Factor

Abstract: PDT using verteporfin induces a reproducible angiogenic response in elderly human eyes. VEGF, VEGFR-3, and PEDF expression is enhanced after PDT. Choroidal endothelial cells appear to be the primary site of angiogenic stimulation.

Cited by 308 publications

References 31 publications

Long-term outcome of intravitreal ranibizumab treatment, compared with photodynamic therapy, in patients with polypoidal choroidal vasculopathy

Long-term outcome of intravitreal ranibizumab treatment, compared with photodynamic therapy, in patients with polypoidal choroidal vasculopathy

Photodynamic therapy combined with posterior subtenon triamcinolone acetonide injection in the treatment of choroidal neovascularization

Photodynamic therapy combined with systemic corticosteroids for choroidal neovascularisation secondary to punctate inner choroidopathy

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