Influence of phenobarbital on serum bilirubin and biliary excretion of bile pigments in gunn rats

Lüders, D

doi:10.1007/bf00438813

Cited by 6 publications

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“…LEVELS These data demonstrate that doses of phenobarbital, sufficient to induce a significant increase in liver weight, cytochrome P-450 content and the activity of microsomal hexobarbital hydroxylase (a cytochrome P-450-dependent MMFO), caused a significant decrease in plasma bilirubin levels in jaundiced Gunn rats, confirming the results of Luders (7) and Davis and Yeary (8). The decrease was maximal after 5 days of treatment, and occurred whether the mean initial plasma bilirubin level was 13.4 mg per dl (Experiment I) or 9.0 mg per dl (Experiment 11).…”

Section: Discussion Effects Of Phenobarbital On Plasma Bilirubinsupporting

confidence: 82%

“…However, the possibility that not only cytochrome P-448-, but also cytochrome P-450dependent, MMFO might be involved in bilirubin catabolism in the Gunn rat, has not been clarified as yet. Two groups have reported a small decline in serum bilirubin after treatment of Gunn rats with phenobarbital (7,8), which preferentially induces cytochrome P-450 MMFO (9), whereas other investigators have not detected such an effect (10,ll). The disagreement among the reported studies, and the absence of isotopic determinations of bilirubin pool size and turnover in most of them, indicate a need for more definitive experiments on the effects of phenobarbital on bilirubin metabolism in the Gunn rat.…”

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confidence: 99%

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Effects of phenobarbital on bilirubin metabolism and its response to phototherapy in the jaundiced gunn rat

et al. 1985

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Jaundiced Gunn rats, treated with phenobarbital (60 mg per kg i.p. for 7 to 10 days) showed 25 and 36% decreases in mean plasma bilirubin levels in two experiments (p less than 0.01). Kinetic studies with tracer 14C-bilirubin revealed that there was no change in bilirubin turnover or total pool size due to phenobarbital, but a 49% increase in the hepatic pool and a 27% decrease in the cutaneous pool of bilirubin. The increase in the hepatic pool accounted for over 90% of the bilirubin lost from the plasma. Such pretreatment with phenobarbital did not alter the decline in plasma bilirubin or total bilirubin pool due to subsequent phototherapy. Phenobarbital followed by phototherapy produced a significantly greater reduction in plasma bilirubin levels than either treatment alone. These studies demonstrate that phenobarbital does decrease plasma bilirubin in Gunn rats primarily by shifting the pigment to the liver, and suggests that combined treatment with phenobarbital and phototherapy might be of value in patients with congenital hyperbilirubinemia due to glucuronyl transferase deficiency.

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Section: Discussion Effects Of Phenobarbital On Plasma Bilirubinsupporting

confidence: 82%

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confidence: 99%