Influence of pharmaceutical care on the delayed emesis associated with chemotherapy

Caracuel, F; Baños, U; Herrera, Marcelino; Ramírez, Gloria; Muñoz, Nuria Muñoz

doi:10.1007/s11096-014-9915-z

Cited by 17 publications

(42 citation statements)

References 8 publications

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“…After reviewing the titles and abstracts, 617 records were excluded because they did not include a study of pharmacist interventions in adult patients with cancer; did not assess the impact of interventions; or included non‐ambulatory patients. The remaining 40 records were selected for full‐text examination, of which 11 met all the eligibility criteria and were included in this systematic review . The excluded studies and the reasons for their exclusion are detailed in Appendix 2.…”

Section: Resultsmentioning

confidence: 99%

“…Sample size ranged from 12 to 249 individuals, with most studies including sample sizes smaller than 100 individuals (n=7) . In most studies (n=10), the mean age of patients was >50 years, and an equal proportion of men and women was recruited. Genitourinary cancer (n=9) was the most evaluated cancer type in this review, followed by gastrointestinal (n=5), breast (n=5), lung (n=5) and haematological cancer (n=3) .…”

Section: Resultsmentioning

confidence: 99%

“…The assessment of the key components of pharmacist interventions showed that the studies were conducted at different outpatient settings, such as clinics, university hospitals and cancer centres or institutes. The main communication method with patients was face‐to‐face contact (72.7%) . The duration of the interventions ranged from 2 to 45 months, with most studies (n=5) reporting a follow‐up time of less than 12 months.…”

Section: Resultsmentioning

confidence: 99%

“…Pharmacists have an important role in identifying drug‐related problems and have taken actions to address them, including providing drug information or patient counselling (81.8%); adjusting support drugs based on protocols previously established in collaboration with the healthcare team (18.2%); suggesting the physician on changes in medication (9.1%); providing drug information to the healthcare team (9.1%); taking laboratory test orders (9.1%); and referring to other healthcare team members, such as psychologists (9.1%) . Most support resources provided by the pharmacists were educational material (concerning oral antineoplastic drugs and support drugs, adverse events and potential drug‐drug interactions) . One study reported blood pressure monitoring for renal cancer patients where patients were advised to note blood pressure values in a disease self‐management diary.…”

Section: Resultsmentioning

confidence: 99%

“…Only six studies included a control group that received usual care (eg, prescription analysis or supply of medicines). The most commonly measured outcomes were rates of nausea and vomiting control (n=4) and patient satisfaction (n=3), followed by quality of life (n=2), adverse drug reaction or adverse event frequency (n=2), drug‐related problem frequency (n=1) and anti‐emesis drug costs (n=1) . Medication adherence (n=3), knowledge‐attitude‐practice for chemotherapy (n=1), awareness and knowledge regarding blood pressure management (n=1) and adherence to laboratory parameter monitoring (n=1) were measured as process indicators.…”

Section: Resultsmentioning

confidence: 99%

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The effects of pharmacist interventions on adult outpatients with cancer: A systematic review

et al. 2017

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SummaryWhat is known and objectives: Most antineoplastic drugs are highly toxic and have low therapeutic indexes, which can result in drug-related problems. In this context, pharmacist interventions may play an important role in the success of the treatment.The objective of this study was to examine the effects of pharmacist interventions on adult outpatients with cancer using antineoplastic drugs. Methods:A literature search was performed using PubMed, ISI Web of Science and LILACS databases from January 1990 to April 2016, using MeSH terms or text words related to pharmacist interventions, cancer and outpatient care. Studies published in English, Portuguese or Spanish on the effects of pharmacist interventions in outcome measures in adult outpatients with cancer were included. Two independent authors performed study selection and data extraction with a consensus process. The articles were analysed according to previously established criteria, such as country, study design, setting, population, type of cancer, description of the intervention and control groups, outcomes, main conclusions and study limitations. Results and discussion:A total of 874 records were identified, of which 11 satisfied the inclusion criteria. The studies were conducted mainly in the United States and included patients aged >50 years. Most studies had a before-after design. Pharmacist interventions primarily included educating and counselling patients on the management of adverse events. Rates of nausea and vomiting control, medication adherence and patient satisfaction were the most common outcome measures; a significant benefit in these parameters as a result of pharmacist interventions was noted in most studies. What is new and conclusion:The findings from this systematic review indicate that pharmacist interventions can improve outcome measures in outpatients with cancer.However, the collective quality of the studies was poor and gaps identified indicate that further research is needed to provide more robust results. K E Y W O R D Scancer, pharmaceutical care, pharmacists, systematic review

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The effects of pharmacist interventions on adult outpatients with cancer: A systematic review

et al. 2017

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Consistency between patients and families in recognizing cancer chemotherapy side effects: A questionnaire survey

et al. 2021

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Background: Although the side effects of cancer chemotherapy impair a patient's quality of life, family members' awareness of side effects may relieve patient anxiety and distress.Aim: We investigated whether patients and their families were consistent in recognizing the occurrence and severity of symptomatic side effects of chemotherapy treatment for cancer.Methods and results: This was a prospective observational study. We administered a questionnaire survey to patients and family members to assess the frequency of occurrence (1: never, 2: almost never, 3: sometimes, 4: frequently, 5: almost always, 6: unknown) and the degree of severity (1: mild, 2: moderate, 3: severe, 4: extremely severe, 5: unknown) of physical and psychological symptoms associated with cancer chemotherapy. Weighted Kappa and Cramer coefficients were used to assess consistency between the two groups. We surveyed 20 pairs of patients (5 men, 15 women) and their families (10 men, 10 women); 17 pairs lived together. The median age was 65.5 years (interquartile [IQR], 58.75, 69.25) for patients and 61.00 years (IQR, 47.25, 71.25) for family members. Of patients, 17 had solid cancer, and three had leukemia. Family members mostly recognized objectively visible symptoms such as hair loss and development of spots and keratinization. However, it was difficult for families to detect invisible subjective symptoms such as weakness, dysesthesia, depressed mood, and unarticulated anxiety. Conclusions:The results indicated that recognition of invisible subjective symptoms in patients undergoing chemotherapy was difficult even for family members. Therefore, a multidisciplinary approach in which various medical professionals actively communicate with both patients and families is important. Information sharing in collaboration with patients and families could increase understanding of the patient's condition and optimize patient care.

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The impact of pharmacist‐led strategies implemented to reduce errors related to cancer therapies: a systematic review

Coutsouvelis

Siderov

Tey

et al. 2020

Pharmacy Practice and Res

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Background Patients with cancer are managed across the whole healthcare spectrum. This complex system of interdependencies has high potential for errors to occur. This is a focus area for pharmacists, who possess the skillset to optimise cancer care across the health care system, identifying errors and other medication‐related problems (MRP). Aim The aim of this study was to identify and describe the impact of the pharmacist’s contribution in reducing cancer therapy‐related errors. Methods A search of English‐language publications in Embase, Medline and CINAHL was conducted. Databases were searched from 1 January 2010 until 29 September 2020 to identify all quantitative studies of a descriptive, observational or experimental design. Articles describing pharmacist‐led interventions in adults receiving one or more cancer therapies including oral chemotherapy, intravenous chemotherapy or immunotherapy compared to no intervention, usual care or a service delivered by another healthcare professional were included. Researchers screened articles to identify eligible studies, and then data were extracted using a standardised data collection sheet. Quality assessment was undertaken using the modified Cochrane and the Newcastle Ottawa risk of bias tools. Data were reported as number or percentage. Results Of 2292 papers identified, nine studies were eligible for inclusion in this review. Pharmacist interventions consistently showed an increased identification of medication errors and medication‐related problems. Pharmacist contributions in many of the included studies comprised medication reviews and monitoring, laboratory monitoring, adverse drug reaction and drug–drug interaction management, adherence monitoring and medication counselling. All studies showed pharmacist intervention in cancer care resulted in fewer errors compared to control arms. Error minimisation was described for parenteral and oral cancer therapies and also for supportive medications such as antiemetics. Conclusion Pharmacists reduce errors and potential patient harm in practice settings where cancer patients are treated. Pharmacists are an integral component of cancer care teams.

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Influence of pharmaceutical care on the delayed emesis associated with chemotherapy

Abstract: The intervention of a pharmacist reduced the incidence of delayed CINV and improved medication adherence.

Cited by 17 publications

References 8 publications

The effects of pharmacist interventions on adult outpatients with cancer: A systematic review

The effects of pharmacist interventions on adult outpatients with cancer: A systematic review

Consistency between patients and families in recognizing cancer chemotherapy side effects: A questionnaire survey

The impact of pharmacist‐led strategies implemented to reduce errors related to cancer therapies: a systematic review

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