Influence of pH on the UV sensitivity of peritoneal macrophage plasma membrane

Pirutin, Sergey K.; Turovetskii, V. B.; Kudryashov, Yu.B.

doi:10.1134/s0006350910010227

Cited by 1 publication

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“…Higher intracellular calcium concentrations could increase the calcium content of the cell membranes, and then the ion, acting as an amplifier, could enhance their mechanisms of lipid peroxidation. It has been reported that calcium is able to alter the stability of macrophage plasma membranes, making them more sensitive to photoperoxidation by UV light [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca²⁺-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants

Chiarello

Marı́n

Proverbio

et al. 2014

BioMed Research International

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In the current study the possible relationship between the Ca2+/Mg2+ ratio of human syncytiotrophoblast plasma membranes and their lipid peroxidation and Ca2+-ATPase activity was determined. Syncytiotrophoblast plasma membranes of placental explants cultured under hypoxia increased their lipid peroxidation and Ca2+ content, diminished their Ca2+-ATPase activity, and kept their Mg2+ content unchanged. Membranes preincubated with different concentrations of Ca2+ increased their Ca2+ content without changes in their Mg2+ content. There is a direct relationship between Ca2+ content and lipid peroxidation of the membranes, as well as an inverse relationship between their Ca2+ content and Ca2+-ATPase activity. On the contrary, preincubation of membranes with different concentrations of Mg2+ showed a higher Mg2+ content without changing their lipid peroxidation and Ca2+-ATPase activity. Explants cultured under hypoxia in the presence of 4 mM MgSO4 showed similar values of lipid peroxidation and Ca2+-ATPase activity of their membranes compared to those of explants cultured under normoxia. Increased Ca2+ content of the membranes by interacting with negatively charged phospholipids could result in destabilizing effects of the membrane structure, exposing hydrocarbon chains of fatty acids to the action of free radicals. Mg2+ might exert a stabilizing effect of the membranes, avoiding their exposure to free radicals.

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Section: Introductionmentioning

confidence: 99%

Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca²⁺-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants

Chiarello

Marı́n

Proverbio

et al. 2014

BioMed Research International

View full text Add to dashboard Cite

show abstract

Influence of pH on the UV sensitivity of peritoneal macrophage plasma membrane

Cited by 1 publication

References 3 publications

Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca²⁺-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants

Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca²⁺-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants

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Influence of pH on the UV sensitivity of peritoneal macrophage plasma membrane

Cited by 1 publication

References 3 publications

Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca2+-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants

Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca2+-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants

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Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca²⁺-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants

Effect of Hypoxia on the Calcium and Magnesium Content, Lipid Peroxidation Level, and Ca²⁺-ATPase Activity of Syncytiotrophoblast Plasma Membranes from Placental Explants