Influence of Peripheral Inflammation on the Postnatal Maturation of Primary Sensory Neuron Phenotype in Rats

Beland, B; Fitzgerald, Maria

doi:10.1054/jpai.2001.17697

Cited by 34 publications

(24 citation statements)

References 46 publications

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“…Others have also shown that there is no difference in the level of CGRP in the contralateral DRGs of neonatal carrageenan-treated rat pups compared with controls. 4 It seems that the intensity of the systemic inflammatory response triggered by using current animal models is not strong enough to change the expression of these molecules in contralateral DRGs; however, more data are needed for a definitive conclusion.…”

Section: Peripheral Inflammation Usually Will Not Affect the Expressimentioning

confidence: 98%

Expression of Neurotrophic Factors in Neonatal Rats After Peripheral Inflammation

Chien¹,

Fu²,

Huang³

et al. 2007

The Journal of Pain

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Section: Peripheral Inflammation Usually Will Not Affect the Expressimentioning

confidence: 98%

Expression of Neurotrophic Factors in Neonatal Rats After Peripheral Inflammation

Chien¹,

Fu²,

Huang³

et al. 2007

The Journal of Pain

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“…The initial postnatal period of life is a critical stage for the development of the peripheral nervous system [1,8,30,31,62], and early life injury produces long-term alterations in nociceptive processing [14,68]. Pain also occurs after injury in pediatric patients at all ages and we observe related effects in developing mice after injury [19] (Fig.…”

Section: Growth Hormone and Nociceptor Sensitizationmentioning

confidence: 73%

Growth hormone regulates the sensitization of developing peripheral nociceptors during cutaneous inflammation: Erratum.

2017

PAIN

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Cutaneous inflammation alters the function of primary afferents and gene expression in the affected dorsal root ganglia (DRGs). However specific mechanisms of injury-induced peripheral afferent sensitization and behavioral hypersensitivity during development are not fully understood. Recent studies in children suggest a potential role for growth hormone (GH) in pain modulation. GH modulates homeostasis and tissue repair after injury, but how GH effects nociception in neonates is not known. To determine if GH played a role in modulating sensory neuron function and hyper-responsiveness during skin inflammation in young mice, we examined behavioral hypersensitivity and the response properties of cutaneous afferents using an ex vivo hairy skinsaphenous nerve-dorsal root ganglion (DRG)-spinal cord preparation. Results show that inflammation of the hairy hindpaw skin initiated at either postnatal day 7 (P7) or P14 reduced GH levels specifically in the affected skin. Furthermore, pretreatment of inflamed mice with exogenous GH reversed mechanical and thermal hypersensitivity in addition to altering nociceptor function. These effects may be mediated via an upregulation of insulin-like growth factor 1 receptor (IGFr1) as GH modulated the transcriptional output of IGFr1 in DRG neurons in vitro and in vivo. Afferent-selective knockdown of IGFr1 during inflammation also prevented the observed injury-induced alterations in cutaneous afferents and behavioral hypersensitivity similar to that following GH pretreatment. These results suggest that GH can block inflammation-induced nociceptor sensitization during postnatal development leading to reduced pain-like behaviors, possibly by suppressing the upregulation of IGFr1 within DRGs.

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“…The unique anatomical structures and physiological processes of preterm and term infants predispose them to greater alterations in their nervous system. Beland and Fitzgerald [21] found carrageenan induced peripheral inflammation at birth alters the proportions and post-natal regulation of calcitonin gene related peptide (CGRP) and isolectin B4 +ve (IB4) cell profiles in neonatal dorsal root ganglia. In adult rats, carrageenan inflammation affected only CGRP cells.…”

Section: Future Pain Responsivity: Evolution For Acute To Persistent mentioning

confidence: 99%

A systematic review of the effects of repeated painful procedures in infants: Is there a potential to mitigate future pain responsivity?

Hatfield

Meyers

Messing

2013

JNEP

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Background: Multiple lines of evidence suggest repeated painful procedures early in life may permanently disrupt the developing central nervous system. Painful diagnostic, medical, and minor surgical procedures performed in the neonatal intensive care unit such as venipunctures, heel lances, immunizations, and central venous catheter insertion are a significant portion of painful events experienced by infants. The objective of this systematic review is to synthesize findings from published clinical trials evaluating the effect of repeated painful procedures experienced during the plasticity of the developing peripheral and central nervous system and their influence on future pain responsivity. Methodology/Principal Findings:A systematic review of peer-refereed clinical trials was conducted. Clinical trials examining the effect of repeated painful procedures experienced during the plasticity of the developing peripheral and central nervous system and their influence on future pain responsivity were identified from electronic databases PUBMED, MEDLINE and CINAHL. Application of inclusion/exclusion criteria and limitations identified five clinical trials for critical reviewed. Findings suggest that repetitive pain experienced during a critical window of neurodevelopment alters the structure and function of an infant's nervous system, influences subsequent pain responses through childhood and may contribute to the development of chronic pain.Conclusions: Current research asserts that inadequate relief of infant pain and distress during tissue-damaging procedures may permanently decrease an individual's pain tolerance, and increase pain responses later in life.

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Influence of Peripheral Inflammation on the Postnatal Maturation of Primary Sensory Neuron Phenotype in Rats

Cited by 34 publications

References 46 publications

Expression of Neurotrophic Factors in Neonatal Rats After Peripheral Inflammation

Expression of Neurotrophic Factors in Neonatal Rats After Peripheral Inflammation

Growth hormone regulates the sensitization of developing peripheral nociceptors during cutaneous inflammation: Erratum.

A systematic review of the effects of repeated painful procedures in infants: Is there a potential to mitigate future pain responsivity?

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