Influence of peripheral and central administration of apomorphine and morphine on intragastric pressure in the dog

Blancquaert, Jean-Pierre; Lefebvre, Romain

doi:10.1016/0014-2999(85)90051-2

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…Thus when gastric filling occurs, the corpus fills without a n undue rise in intragastric pressure. Additional corpus relaxation, for example as evoked by feedback from the duodenum during gastric emptying (17) or as part of the prodromal visceral response of emesis (18), imparts fine control over the gastric reservoir function, enabling gastric contents to be retained in the proximal stomach as a means of delaying the aboral progression of chyme. Such responses are likely to come about via concomitant changes in the level of discharge in the cholinergic and NANC vagal pathways, which in turn modifies the gain of the local enteric circuits.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Gastric Corpus Tone by the Vagus Nerve in the Ferret

Grundy

Naseri

Hutson

1991

Neurogastroenterology Motil

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The pressure‐volume relationship of the ferret gastric corpus was investigated to quantify the relative contributed of cholinergic and nonadrenergic, noncholinergic (NANC) mechanisms to the volume‐accommodating property of this region. In splanchnectomized animals under control conditions the pressure‐volume relationship of the corpus fitted a linear regression (Y = 0.30X + 0.57). Atropine decreased the magnitude of the pressure rise per unit volume, while after vagotomy this effect was reversed. The magnitude of these pressure changes in individual animals was consistent with reciprocal regulation of cholinergic and NANC pathways. Moreover, after vagotomy the shape of the pressure‐volume curve was altered such that the pressure rise per unit volume was greater at the lower distending volumes. Continuous, low‐frequency electrical vagal stimulation restored the pressure‐volume relationship to that seen prior to vagotomy, an effect abolished by hexamethonium (25 mg/kg). Vasoactive intestinal polypeptide, on the other hand, caused a dose‐related reduction in corpus pressure during the ramp increases in volume comparable to that seen during electrical stimulation but did not restore the shape of the pressure‐volume curve. These data indicate that the action of the vagus may in part be permissive, with the sensitivity of local NANC pathways being modulated by a vagal cholinergic input.

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Section: Discussionmentioning

confidence: 99%

Regulation of Gastric Corpus Tone by the Vagus Nerve in the Ferret

Grundy

Naseri

Hutson

1991

Neurogastroenterology Motil

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“…For instance, intravenous administration of apomorphine, that is a nonspecific dopaminergic agonist and induces emesis, evokes two distinct gastric motor responses in rat. One is the inhibition of phasic contractions that appear just after administration (Abrahamsson et al, 1973;Blancquaert et al, 1985), and the other is an increase in the frequency of small phasic contractions accompanied by increased gastric tone appearing with a relatively longer delay (Koga et al, 2003). Nicotine is also known to induce excitatory and inhibitory effects on the gastrointestinal tract, some of which may be caused by interaction of nicotine with nAChR in the medullla oblongata (Nagata and Osumi, 1991;Ferreira et al, 2000Ferreira et al, , 2001.…”

Section: Discussionmentioning

confidence: 99%

Effects of Z-338, a novel gastroprokinetic agent, on the actions of excitatory and inhibitory neurotransmitters on neurons in area postrema

Akaike

Jang

Hori

et al. 2010

J. Smooth Muscle Res.

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We investigated the effects of the novel gastroprokinetic agent Z-338 on the actions of excitatory and inhibitory neurotransmitters on neurons in area postrema (AP). Iontophoretic applications of acetylcholine (ACh), AMPA and NMDA increased, while GABA suppressed the firing rates of AP neurons recorded by extracellular electrodes. Z-338 (10 µM) suppressed the ACh-induced acceleratory and GABA-induced inhibitory actions without affecting the excitatory actions of AMPA and NMDA. Under voltageclamp conditions, nicotine, NMDA, kainic acid (KA) and ATP evoked inward currents in dissociated single AP neurons recorded by whole-cell patch clamp technique, and GABA produced outward currents, at holding potentials (VH) of -60 or 0 mV. Z-338 (>3 µM) specifically suppressed the nicotine-and GABA-induced currents without affecting the currents induced by NMDA, KA and ATP. In addition, we found that Z-338 (30 µM) suppressed the spontaneous inhibitory postsynaptic currents (sIPSCs) recorded from AP neurons in slice preparations. Experiments with microelectrode and histochemical methods revealed the presence of direct excitatory and di-synaptic inhibitory neural connections from AP to dorsal motor nucleus of the vagus (DMV). In some AP neurons, Z-338 (10 µM) enhanced the spontaneous firing rates recorded by extracellular electrode.The excitatory or inhibitory effects of Z-338 on the firing rates or actions of nicotine and GABA on AP neurons observed in the present study may explain the postmeal relaxation induced by Z-338 in patients with functional dyspepsia.

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Gastrointestinal Dopamine Receptors

Lefebvre¹

1988

Peripheral Actions of Dopamine

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Influence of peripheral and central administration of apomorphine and morphine on intragastric pressure in the dog

Cited by 7 publications

References 14 publications

Regulation of Gastric Corpus Tone by the Vagus Nerve in the Ferret

Regulation of Gastric Corpus Tone by the Vagus Nerve in the Ferret

Effects of Z-338, a novel gastroprokinetic agent, on the actions of excitatory and inhibitory neurotransmitters on neurons in area postrema

Gastrointestinal Dopamine Receptors

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