Influence of perinatal trans fat on behavioral responses and brain oxidative status of adolescent rats acutely exposed to stress

Olive oil-enriched diet reduces brain oxidative damages and ameliorates neurotrophic factor gene expression in different life stages of rats

“…In addition, recent reports from our group have shown a significant relationship between behavioral and molecular damage to the CNS and the type of dietary FA, with no quantitative influence since the diets had the same fat content [37][38][39][40], indicating that the type of FA is able to exert a key role on cellular functions. In this sense, although the diets used in the current study present different fat amounts, we believe that the beneficial influence of OOED observed result from the FA present in olive oil, with no influence of fat amount.…”

Toxicological aspects of trans fat consumption over two sequential generations of rats: Oxidative damage and preference for amphetamine

“…Rats were randomly assigned to one of four experimental groups (n = 8 for each group): Control (C, received only water), soybean oil (SO, rich in n-6 FA), fish oil (FO, rich in n-3 FA) and HVF (rich in TFA), which were supplemented daily by oral gavage with 3.0 g/kg body weight from conception until weaning of pups. Supplementations were administered according to previous studies of our own Pase et al, 2013;Kuhn et al, 2013) and of other groups (Vines et al, 2012;Ferraz et al, 2011). The different amounts of polyunsaturated, saturated, monounsaturated, omega-3, omega-6 and trans fatty acids present in the different supplementations are shown in Table 1.…”

Chronic consumption of trans fat can facilitate the development of hyperactive behavior in rats

“…Regular consumption of TFA may eventually result in a loss of EFA, with unpredictable impacts on human health, because TFA derivatives may be incorporated into membrane phospholipids [25] and alter membrane fluidity, plasticity and neurotransmission [26,27]. Trans fat intake has also been linked to cognitive dysfunction [28,29], changes in dopaminergic neurotransmission [30], addiction [31], mania [32], movement disorders [25] and higher sensitivity to stress and anxiety [33].…”