Influence of Perinatal Factors in Short- and Long-Term Outcomes of Infants Born at 23 Weeks of Gestation

Miltaha, Hamzah R.; Fahey, Lisa M.; Sajous, Christine H.; Morrison, John C.; Muraskas, Jonathan

doi:10.1055/s-0034-1390350

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…Across follow-up ages, the prevalence of any NDI in North America was 8%–59%. The prevalence of moderate NDI was 39% in the single North American study that reported moderate NDI, 27 versus 3%–19% in included European studies. A meta-analysis that included birth cohorts in a median year of 2000 or later (median age at assessment, 28 months) estimated that 52% of surviving infants born extremely preterm worldwide develop NDI (defined as cognitive, motor, hearing, and visual impairment) to some degree; 86 this is in line with the NDI prevalence in North America found in the present SLR of more recent data.…”

Section: Discussionmentioning

confidence: 85%

“…The prevalence of severe NDI ranged from 12% to 27% across all follow-up durations (reported in four studies). 23,27,28,37 The prevalence of any CP was 8%–54% at 18 months to 2 years follow-up, 19,23,31,32 5%–11% between 2 and 5 years follow-up, 35,37 and 7% at ≥5 years follow-up. 40…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-four North American studies reported findings for NDI (United States, 20; Canada, four) (Table 1). 18–41 Of those studies, 13 were of prospective design and 11 were retrospective. Sample size varied considerably, ranging from 44 to 3608.…”

Section: Resultsmentioning

confidence: 99%

“…Sample size varied considerably, ranging from 44 to 3608. 20,27 The reported prevalence of any NDI (in studies that reported an aggregate of NDI of any type or severity) among children born extremely preterm ranged from 8% to 59% at 18 months to 2 years follow-up, 18,26 and from 11% to 37% between 2 and 5 years follow-up (Figure 2; Table 1). 35,39 No studies reported the proportion of children with any NDI at ≥5 years follow-up.…”

Section: Resultsmentioning

confidence: 99%

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Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review

Sarda

Sarri²,

Siffel

2021

J Int Med Res

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Objective Neurodevelopmental impairment (NDI) is a major complication of extreme prematurity. This systematic review was conducted to summarize the worldwide long-term prevalence of NDI associated with extreme prematurity. Methods Embase and MEDLINE databases were searched for epidemiologic and observational/real-world studies, published in English between 2011 and 2016, reporting long-term prevalence of NDI (occurring from 1 year) among extremely preterm infants born at gestational age (GA) ≤28 weeks. Results Of 2406 articles identified through searches, 69 met the protocol NDI definition (24 North America, 25 Europe, 20 Rest of World). Prevalence of any severity NDI in North America was 8%–59% at 18 months to 2 years, and 11%–37% at 2–5 years; prevalence of moderate NDI in Europe was 10%–13% at 18 months to 2 years, 3% at 2–5 years, and 9%–19% at ≥5 years; prevalence of any NDI in Rest of World was 15%–61% at 18 months to 2 years, and 42% at 2–5 years (no North America/Rest of World studies reported any NDI at ≥5 years). A trend toward higher prevalence of NDI with lower GA at birth was observed. Conclusions Extreme prematurity has a significant long-term worldwide impact on neurodevelopmental outcomes.

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Section: Discussionmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review

Sarda

Sarri²,

Siffel

2021

J Int Med Res

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Past and Present: A Review of Antenatal Corticosteroids and Recommendations for Late Preterm Birth Steroids

et al. 2018

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Since 1972, the beneficial neonatal effects of antenatal corticosteroids (ACSs) have been repeatedly demonstrated in pregnancies at risk of preterm birth before 34 weeks' gestation. While ACS utilization before 34 weeks has been high since the 1990s, knowledge gaps regarding the risks and benefits of ACS continue to exist. Recent evidence has been published regarding the benefit of ACS in the late preterm period. This review addresses the evidence and knowledge gaps for ACS use before and after 34 weeks' gestation. We also provide recommendations for ACS use in the late preterm period.

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Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol

et al. 2016

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IntroductionOver 80% of very preterm (<32 weeks) and very low birthweight (<1500 g) infants will have either typical development (TD) or mild developmental delay (MDD) in multiple domains. As differentiation between TD and MDD can be difficult, infants with MDD often miss opportunities for intervention. For many clinicians, the ongoing challenge is early detection of MDD without over servicing the population. This study aims to: (1) identify early clinical biomarkers for use in this population to predict and differentiate between TD and MDD at 24 months corrected age. (2) Determine the extent to which family and caregiver factors will contribute to neurodevelopmental and behavioural outcomes.Methods and analysisParticipants will be a prospective cohort of 90 infants (<32 weeks and/or <1500 g). Between 34 weeks gestational age and 16 weeks post-term, infants will have a series of 5 neurological, neuromotor, neurobehavioural and perceptual assessments including General Movement Assessment at preterm, writhing and fidgety age. Primary caregivers will complete questionnaires to identify social risk, maternal depression and family strain. Extensive perinatal data will be collected from the medical record. At 24 months, corrected age (c.a) infants will be assessed using standardised tools including the Bayley Scales of Infant and Toddler Development—Third Edition (Bayley III). Longitudinal trajectories of early assessment findings will be examined to determine any predictive relationship with motor and cognitive outcomes at 24 months c.a. Published data of a cohort of Australian children assessed with the Bayley III at 24 months c.a will provide a reference group of term-born controls.EthicsEthical approval has been obtained from the Queensland Children's Health Services Human Research Ethics Committee (HREC/13/QRCH/66), the University of Queensland (2013001019) and the Sunshine Coast Hospital and Health Service, SC-Research Governance (SSA/13/QNB/66). Publication of all study outcomes will be in peer-reviewed journals.Trial registration numberACTRN12614000480684; Pre-results.

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Influence of Perinatal Factors in Short- and Long-Term Outcomes of Infants Born at 23 Weeks of Gestation

Abstract: Multiple perinatal factors significantly influence outcomes at the threshold of viability.

Cited by 3 publications

References 21 publications

Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review

Global prevalence of long-term neurodevelopmental impairment following extremely preterm birth: a systematic literature review

Past and Present: A Review of Antenatal Corticosteroids and Recommendations for Late Preterm Birth Steroids

Early prediction of typical outcome and mild developmental delay for prioritisation of service delivery for very preterm and very low birthweight infants: a study protocol

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