Influence of perceived psychological stress and distress on antibody response to low dose rDNA hepatitis B vaccine

Jabaaij, Lea; Grosheide, P.M.; Heijtink, R. A.; Duivenvoorden, Hugo J.; Ballieux, R. E.; Vingerhoets, A.J.J.M.

doi:10.1016/0022-3999(93)90138-6

Cited by 98 publications

(60 citation statements)

References 39 publications

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“…The negative influence of these context-inappropriate perceptions of stress suggest that personality factors may also be implicated in determining the adequacy of the antibody response. This resonates with the results reported for thymus-dependent vaccinations, in which higher negative affect [40], neuroticism [54], and psychological symptoms [38] are associated with poorer antibody titres, and suggests that conjugate vaccines may be similarly susceptible to psychological influence.…”

Section: Conjugate Vaccinationssupporting

confidence: 87%

“…Nevertheless, this study implies that psychological stress may have its principal effects on the rate of deterioration of protection. Jabaaij and colleagues [38] found a poorer antibody response to a low dose hepatitis B vaccination in those with a higher Stress Index at two months after vaccination. There was also a tendency for antibody titre to be related to the Stress Index at 6 months.…”

Section: Thymus-dependent Vaccinationsmentioning

confidence: 98%

“…If this is to be achieved by questionnaire, separate and validated measures of life events exposure, perceived stress, and psychological distress, are to be preferred to the composite measures of stress that have sometimes been used previously [38]. This approach would allow a better understanding of the extent to which immune function is affect be exposure to stressful life events, perceptions of stress, or an interaction between the two.…”

Section: Theoretical Studiesmentioning

confidence: 99%

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Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Burns

Carroll

Ring

et al. 2003

Vaccine

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The purpose of this review is to determine the effects of psychosocial stress on antibody response to vaccination in humans, consider possible mechanisms, and identify agenda for future research. Studies of the association between stress and vaccination response in humans were reviewed. There is evidence of a negative association between stress and antibody response to vaccination, which is most apparent with thymusdependent vaccines and when measured at extended times after vaccination. Preliminary findings implicate the hypothalamic-pituitary-adrenal axis and sympathetic nervous system as potential mechanisms, although a role for unhealthy behaviours cannot be discounted at this stage. Results to date are sufficiently indicative to direct future research to untangling their theoretical ramifications, as well as realising their clinical implications.

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Section: Conjugate Vaccinationssupporting

confidence: 87%

Section: Thymus-dependent Vaccinationsmentioning

confidence: 98%

Section: Theoretical Studiesmentioning

confidence: 99%

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Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Burns

Carroll

Ring

et al. 2003

Vaccine

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“…Objective scores of chronic stress such as loneliness, psychoneurotic complaints, depression, irascibility, and anxiety have been used to study effects of stress on the immune system in humans (63)(64)(65)(66)(67)(68)(69)(70). Chronic stress diminishes the efficacy of the immune system to protect the host against infections.…”

Section: Effect Of Chronic Psychological Stress On the Vaccination Rementioning

confidence: 99%

“…Generally, high levels of stress (negative life events, academic exams, daily stress) and anxiety appear to reduce the antibody response to a primary or secondary immunization with a vaccine. Jabaaij et al (63) performed a study in stressed subjects characterized by loneliness, daily hassles, psychoneurotic complaints, and submissive coping style. Subjects were vaccinated and antibody titers determined 7 months later.…”

Section: Effect Of Chronic Psychological Stress On the Vaccination Rementioning

confidence: 99%

Vaccine-Induced Antibody Responses as Parameters of the Influence of Endogenous and Environmental Factors

Loveren¹,

Amsterdam²,

Vandebriel³

et al. 2001

Environmental Health Perspectives

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In laboratory animals, an adequate way to assess effects of environmental exposures on the immune system is to study effects on antigen-specific immune responses, such as after sensitization to T-cell-dependent antigens. This probably also applies to testing effects in the human population. It has thus been suggested that antibody responses to vaccination might be useful in this context. Vaccination responses may be influenced by a variety of factors other than environmental ones. One factor is the vaccine itself; a second is the vaccination procedure used. In addition, the intrinsic capacity of the recipient to respond to a vaccine, which is determined by sex, genetic factors, and age, is important. Psychological stress, nutrition, and (infectious) diseases are also likely to have an impact. We reviewed the literature on vaccine response. With regard to exogenous factors, there is good evidence that smoking, diet, psychological stress, and certain infectious diseases affect vaccination titers, although it is difficult to determine to what extent. Genetic factors render certain individuals nonresponsive to vaccination. In general, in epidemiologic studies of adverse effects of exposure to agents in the environment in which vaccination titers are used, these additional factors need to be taken into consideration. Provided that these factors are corrected for, a study that shows an association of exposure to a given agent with diminished vaccination responses may indicate suboptimal function of the immune system and clinically relevant diminished immune response. It is quite unlikely that environmental exposures that affect responses to vaccination may in fact abrogate protection to the specific pathogen for which vaccination was performed. Only in those cases where individuals have a poor response to the vaccine may exogenous factors perhaps have a clinically significant influence on resistance to the specific pathogen. An exposure-associated inhibition of a vaccination response may, however, signify a decreased host resistance to pathogens against which no vaccination had been performed.

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Stress-Induced Immunomodulation

Glaser¹,

Rabin²,

Chesney³

et al. 1999

JAMA

142

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Influence of perceived psychological stress and distress on antibody response to low dose rDNA hepatitis B vaccine

Cited by 98 publications

References 39 publications

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Antibody response to vaccination and psychosocial stress in humans: relationships and mechanisms

Vaccine-Induced Antibody Responses as Parameters of the Influence of Endogenous and Environmental Factors

Stress-Induced Immunomodulation

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