Influence of pentoxifylline on gene expression of PAG1/ miR-1206/ SNHG14 in ischemic heart disease

el-Aziz, Ahlam Abd; El-Desouky, Mohamed A.; Shafei, Ayman; Elnakib, Mostafa; Abdelmoniem, Amr M.

doi:10.1016/j.bbrep.2021.100911

Cited by 5 publications

(4 citation statements)

References 46 publications

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“…It was found that could be used as the biomarker for ischemia reperfusion diagnosis. 24 MiR‐1206 variant was confirmed to be related to methotrexate‐induced oral mucositis in childhood acute lymphoblastic leukemia. 25 In cancer, Yu et al 26 showed that circ_0092367 suppressed epithelial‐mesenchymal transition process and gemcitabine resistance via miR‐1206 in pancreatic cancer.…”

Section: Discussionmentioning

confidence: 94%

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Circ_0043256 upregulates KLF2 expression by absorbing miR‐1206 to suppress the tumorigenesis of lung cancer

et al. 2023

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Background Circular RNAs (circRNAs) have been reported to play roles in lung cancer development. The purpose of this work was to explore the function and mechanism of circ_0043256 in lung cancer tumorigenesis. Methods Quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blot were used for the detection of the levels of genes and proteins. Cell growth, angiogenesis ability, migration, and invasion were analyzed by using 5‐ethynyl‐2′‐deoxyuridine (EdU) assay, flow cytometry, tube formation assay, transwell assay, and murine xenograft model, respectively. The target between miR‐1206 and circ_0043256 or Krüppel‐like factor 2 (KLF2) was verified by dual‐luciferase reporter assay. Results Circ_0043256 was a stable circRNA, which was found to be decreased in lung cancer tissues and cells. Functionally, forced expression of circ_0043256 suppressed lung cancer cell growth, angiopoiesis, migration, and invasion. Mechanistically, circ_0043256 directly bound to miR‐1206 and miR‐1206 targeted KLF2, circ_0043256 could regulate KLF2 expression via absorbing miR‐1206. Rescue assay showed that miR‐1206 overexpression reversed the anticancer effects of circ_0043256 on lung cancer cells. Moreover, inhibition of miR‐1206 could suppress the malignant phenotypes of lung cancer cells, which was attenuated by KLF2 knockdown. Pre‐clinically, lentivirus‐mediated circ_0043256 overexpression impeded lung cancer growth in nude mice. Conclusion Forced expression of circ_0043256 could impede the tumorigenesis of lung cancer via miR‐1206/KLF2 axis, indicating a potential therapeutic approach for lung cancer.

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Section: Discussionmentioning

confidence: 94%

“…MiR‐1206 is a functional miRNA. It was found that could be used as the biomarker for ischemia reperfusion diagnosis 24 . MiR‐1206 variant was confirmed to be related to methotrexate‐induced oral mucositis in childhood acute lymphoblastic leukemia 25 .…”

Section: Discussionmentioning

confidence: 98%

Circ_0043256 upregulates KLF2 expression by absorbing miR‐1206 to suppress the tumorigenesis of lung cancer

et al. 2023

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“…In osteosarcoma, miR-593-3p can inhibit tumorigenesis by promoting the upregulation of zinc finger E-box binding homeobox 2( 50 ). SNHG14( 51 ) and MAP3K2( 52 ) genes have been shown to serve as targets of miR-1206 and miR-1208 respectively, and miR-1206 and miR-1208 can act as targets for tumor suppression.…”

Section: Discussionmentioning

confidence: 99%

Role of the circular RNA regulatory network in the pathogenesis of biliary atresia

Liu,

Dong,

Gao

et al. 2024

Exp Ther Med

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Circular RNAs (circRNAs) serve an essential role in the occurrence and development of cholangiocarcinoma, but the expression and function of circRNA in biliary atresia (BA) is not clear. In the present study, circRNA expression profiles were investigated in the liver tissues of patients with BA as well as in the choledochal cyst (CC) tissues of control patients using RNA sequencing. A total of 78 differentially expressed circRNAs (DECs) were identified between the BA and CC tissues. The expression levels of eight circRNAs (hsa_circ_0006137, hsa_circ_0079422, hsa_circ_0007375, hsa_circ_0005597, hsa_circ_0006961, hsa_circ_0081171, hsa_circ_0084665 and hsa_circ_0075828) in the liver tissues of the BA group and control group were measured using reverse transcription-quantitative polymerase chain reaction. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis demonstrated that the identified DECs are involved in a variety of biological processes, including apoptosis and metabolism. In addition, based on the GO and KEGG pathway enrichment analyses, it was revealed that target genes that can be affected by circRNAs regulatory network were enriched in the TGF-β signaling pathway, EGFR tyrosine kinase inhibitor resistance pathway and transcription factor regulation pathway as well as other pathways that may be associated with the pathogenesis of BA. The present study revealed that circRNAs are potentially implicated in the pathogenesis of BA and could help to find promising targets and biomarkers for BA.

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“…Therapeutic intervention targeting PAG could take the form of an inhibitory antibody or a compound to change expression level. The anti-inflammatory/vasodilatory drug pentoxifylline has been shown to decrease PAG expression levels in T cells ( 169 ). Because PAG is a transmembrane protein, it can be targeted by the same approach used in traditional immunotherapy – development of an antibody to bind and inhibit signaling.…”

Section: Pagmentioning

confidence: 99%

Combination Approaches to Target PD-1 Signaling in Cancer

2022

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Cancer remains the second leading cause of death in the US, accounting for 25% of all deaths nationwide. Immunotherapy techniques bolster the immune cells’ ability to target malignant cancer cells and have brought immense improvements in the field of cancer treatments. One important inhibitory protein in T cells, programmed cell death protein 1 (PD-1), has become an invaluable target for cancer immunotherapy. While anti-PD-1 antibody therapy is extremely successful in some patients, in others it fails or even causes further complications, including cancer hyper-progression and immune-related adverse events. Along with countless translational studies of the PD-1 signaling pathway, there are currently close to 5,000 clinical trials for antibodies against PD-1 and its ligand, PD-L1, around 80% of which investigate combinations with other therapies. Nevertheless, more work is needed to better understand the PD-1 signaling pathway and to facilitate new and improved evidence-based combination strategies. In this work, we consolidate recent discoveries of PD-1 signaling mediators and their therapeutic potential in combination with anti-PD-1/PD-L1 agents. We focus on the phosphatases SHP2 and PTPN2; the kinases ITK, VRK2, GSK-3, and CDK4/6; and the signaling adaptor protein PAG. We discuss their biology both in cancer cells and T cells, with a focus on their role in relation to PD-1 to determine their potential in therapeutic combinations. The literature discussed here was obtained from a search of the published literature and ClinicalTrials.gov with the following key terms: checkpoint inhibition, cancer immunotherapy, PD-1, PD-L1, SHP2, PTPN2, ITK, VRK2, CDK4/6, GSK-3, and PAG. Together, we find that all of these proteins are logical and promising targets for combination therapy, and that with a deeper mechanistic understanding they have potential to improve the response rate and decrease adverse events when thoughtfully used in combination with checkpoint inhibitors.

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Influence of pentoxifylline on gene expression of PAG1/ miR-1206/ SNHG14 in ischemic heart disease

Cited by 5 publications

References 46 publications

Circ_0043256 upregulates KLF2 expression by absorbing miR‐1206 to suppress the tumorigenesis of lung cancer

Circ_0043256 upregulates KLF2 expression by absorbing miR‐1206 to suppress the tumorigenesis of lung cancer

Role of the circular RNA regulatory network in the pathogenesis of biliary atresia

Combination Approaches to Target PD-1 Signaling in Cancer

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