Influence of paternal age on ongoing pregnancy rate at eight weeks' gestation in assisted reproduction

Meijerink, A.M.; Ramos, Liliana; Fleischer, Kathrin; Veltman, Joris A.; Hendriks, Jan C.M.; Braat, D.D.M.

doi:10.1016/j.rbmo.2015.09.017

Cited by 22 publications

(24 citation statements)

References 31 publications

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“…Some works suggested a negative correlation between paternal age and fertilization rate (Aboulghar et al, ; Katib, Al‐Hawsawi, Motair, & Bawa, ; Luna et al, ), embryo quality, implantation rate, and pregnancy rate (Belloc et al, ; Bellver, Garrido, Remohí, Pellicer, & Meseguer, ; Frattarelli et al, ; Katib et al, ; Klonoff‐Cohen & Natarajan, ; Luna et al, ; Robertshaw, Khoury, Abdallah, Warikoo, & Hofmann, ; Sharma et al, ). Conversely, others did not find any effect of paternal age on the rates of pregnancy, miscarriage, and live births (Alfaraj & Yunus, ; Alshahrani et al, ; Fernandez‐Gonzalez et al, ; Jaleel & Khan, ; Kong et al, ; Meijerink et al, ; Pérez‐Crespo, Moreira, et al, ; Pérez‐Crespo, Pintado, et al, ; Whitcomb et al, ) especially in first IVF/ICSI cycles (Meijerink et al, ). As many different factors, such as maternal age, ART procedure and semen quality, should be considered when assessing the effects of paternal age on IVF outcomes, these discrepancies could be partially explained by the different study protocols/populations.…”

Section: Discussionmentioning

confidence: 98%

Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years

Kaarouch

Bouamoud

Madkour

et al. 2018

Molecular Reproduction Devel

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This study assessed sperm quality declining on relation to paternal age and its impact on in vitro fertilization (IVF) outcomes in order to estimate the APA (Advanced Paternal Age) cutoff. For this, 83 couples undergoing IVF treatment for male factor infertility were enrolled. The women age was ≤39 years, whereas the men were divided in two groups: APA (n = 41; age ≥ 40 years) and young (Y) (n = 42; age < 40 years). Conventional semen parameters (volume, concentration, motility, vitality, and morphology) were analyzed in the collected sperm samples. Furthermore, sperm genome decays (SGD) was assessed by TUNEL assay (DNA fragmentation), aniline blue staining (chromatin decondensation), and fluorescent in situ hybridization (aneuploidy). No significant difference was found concerning the conventional semen parameters between APA and Y groups. Conversely, SGD analysis showed increased DNA fragmentation; chromatin decondensation and sperm aneuploidy rates in the APA group (respectively, 41%, 43%, and 14% vs. 25%, 23%, and 4% in Y group). IVF outcomes also were affected by paternal age as indicated by the rates of cancelled embryo transfers, clinical pregnancy and miscarriage in the two groups APA and Y (29%, 17%, and 60% vs. 10%, 32%, and 42%). Finally, statistical analysis of the results suggests that the age of 40 should be considered as the APA cutoff during ART attempts.

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Section: Discussionmentioning

confidence: 98%

Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years

Kaarouch

Bouamoud

Madkour

et al. 2018

Molecular Reproduction Devel

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“…The effect of the age difference between the male and female partner ages (Δ = M age -F age ) that gave OR Δ = 1.04 (CI 95% :1.0–1.08) pointing out the rising probability of pregnancy when the female partner is younger is noticeable. In the present study, according to Meijerink et al (16), we used the probability of obtaining only one or no type A embryo (N A ≤1) as a negative indicator to evaluate the reduced efficacy of the biological outcome. The probability of N A ≤1 increases with both male and female age (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

“…However, in women aged 30–34 years old, the implantation rate dropped with increasing paternal age and the pregnancy rate was significantly higher with male partners aged <30 years or 30–32 years compared to men aged 36–38 or 39–41 years. Meijerink et al (16) conducted a retrospective study on 7,051 IVF/ICSI cycles. They did not found any statistically significant difference in pregnancy rate for men aged 35–44 years or for men ≥45 years compared to the control group of men <35 years.…”

Section: Discussionmentioning

confidence: 99%

Impact of Paternal Age on Seminal Parameters and Reproductive Outcome of Intracytoplasmatic Sperm Injection in Infertile Italian Women

et al. 2019

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Background: We conducted a retrospective study on a cohort of couples attending the Department of Andrology and Reproductive Physiopathology at Sandro Pertini Hospital in Rome for Intracytoplasmatic Sperm Injection (ICSI)-assisted reproduction programs. Some of the couples included in the study underwent more than one ICSI cycle. Between January 2015 and April 2017. Objective: To evaluate whether the advancing of the paternal age may have effect on the seminal parameters, thus negatively affecting the embryo formation, development and quality, as well as the pregnancy rate. Materials and Methods: Five hundred and forty three ICSI cycles were performed on 439 couples undergoing Assisted Reproductive Technologies (ART). Patients were subdivided into three male and three female age groups having similar size: Men: ≤38 years (M I ), 39–43 years (M II ), ≥44 years (M III ). Women: ≤35 years (F I ), 36–40 years (F II ),≥41 years (F III ). Discussion and Conclusion: Male age groups did not reveal any statistical significant differences in any age-related semen parameters. We also confirmed a statistical significant increase in the pregnancy rate of couples with older partner age difference and younger female. We found that the advanced male age increases the probability of obtaining one or no type A embryo (N A ≤1), which was almost doubled in the M III group in comparison with M I , suggesting a negative effect of male age on the efficacy of the reproductive outcome in terms of a reduced number of type A embryos. Such an effect does not seem related to semen parameters and may deserve further investigations.

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“…Since that review, a number of larger cohort studies have been performed, however, the results of these studies have been contradictory. Some studies have found that paternal age has a detrimental effect on outcome (19)(20)(21)43) and others have not found evidence of a detrimental effect (21,30,44,45). A systematic review of studies performed using the donor egg model suggested that advancing paternal age is not associated with adverse oocyte donation outcomes (17).…”

Section: Discussionmentioning

confidence: 99%

Effect of paternal age on outcomes in assisted reproductive technology cycles: systematic review and meta-analysis

et al. 2020

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Objective: To investigate whether paternal age exerts an independent effect on the clinical outcomes of assisted reproductive technology (ART) cycles. Evidence Review: Observational studies were identified through a systematic search of MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and National Health Service evidence. Data for women aged %39 years were extracted and analyzed. We included all studies, both autologous and donor oocyte, into separate analyses of the effect of paternal age on ART outcome. We excluded studies in azoospermic men, women aged R40 years, ART including preimplantation genetic testing, and involving donor sperm. The included studies scored well on the Newcastle-Ottawa Quality Assessment Scale for observational studies. The primary outcome was live birth rate and secondary outcome measures were clinical pregnancy rate and miscarriage rate. When pooling data, the random-effects model was used to counter the effect of heterogeneity in the studies. Result(s): Live birth rate was reported in three autologous oocyte studies (2,926 cycles) and five donor oocyte studies (7,648 cycles). Live birth rate was found to be increased significantly when male age was <40 years in autologous oocyte studies but no difference in live birth rate was found in donor oocyte studies. Clinical pregnancy rates were found to be statistically higher when the paternal age was under 40 years in autologous oocyte studies, however, there was no difference in clinical pregnancy in the same age category when donor oocyte studies were analyzed. Miscarriage rate was reported in two autologous oocyte studies (970 cycles) and four donor oocyte studies (3,741 cycles). Miscarriage was found to be more likely with male age >40 years in autologous studies. In donor oocyte studies, the miscarriage rate was not increased when male age was >50 years. All of the autologous oocyte studies reported a statistically significant association between male age and female age. Conclusion(s): The findings of this review and meta-analysis, based on the donor oocyte model, suggest that advanced paternal age does not exert an independent effect on the outcome of ART cycles. Miscarriage rates do not appear to be increased even for men >50 years of age after treatment with donor oocytes. The meta-analysis of autologous oocyte studies suggests that increasing male age may have a deleterious effect on the outcome of ART, however, this may be confounded by the strong association with increasing maternal age. (Fertil Steril Rev Ò 2020;1:16-34. Ó2020 by American Society for Reproductive Medicine.

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Influence of paternal age on ongoing pregnancy rate at eight weeks' gestation in assisted reproduction

Cited by 22 publications

References 31 publications

Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years

Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years

Impact of Paternal Age on Seminal Parameters and Reproductive Outcome of Intracytoplasmatic Sperm Injection in Infertile Italian Women

Effect of paternal age on outcomes in assisted reproductive technology cycles: systematic review and meta-analysis

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