Influence of Partial-Body X-Irradiation on Development of Phosphorothioate Oxidase in the Livers of Male Rats

Hietbrink, Bernard E.; DuBois, Kenneth P.

doi:10.2307/3571849

Cited by 7 publications

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“…Greengard, Baker, Horowitz & Knox (1966) found that radiation impaired the induction of hepatic tryptophan pyrrolase (EC 1.13.1.12) by tryptophan but not by hydrocortisone; however, the induction of tryptophan pyrrolase by hydrocortisone was reported to be radiosensitive by Mishkin, Shore & Davis (1967). Hietbrink & DuBois (1966) and Nair & Zeitlin (1967) observed that irradiation to the head alone inhibited the development of two enzymes of the rat liver. This varied effect of ionizing radiation on enzyme formation justifies further studies, particularly with respect to radiosensitivity of constitutive enzyme synthesis, a subject that has thus far received little attention.…”

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“…Effect ofpartial body irradiation. Since irradiation to the head has been reported to inhibit the synthesis of liver enzymes (Hietbrink & DuBois, 1966;Nair & Zeitlin, 1967) it was decided to test whether the brain was similarly a target of such abscopal effects. Irradiation (500 r) to the body, with the head shielded, at 20 days of age had no effect on the postirradiation formation of glycerol phosphate dehydrogenase.…”

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Time-dependence of the effect of X-irradiation on the formation of glycerol phosphate dehydrogenase and other dehydrogenases in the developing rat brain

Vellis

Schjeide

1968

Biochemical Journal

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X-irradiation (100–1500 r) administered to the heads of rats 8–30 days of age inhibited the development of glycerol phosphate dehydrogenase (l-glycerol 3-phosphate–NAD oxidoreductase, EC 1.1.1.8) in the brain stem and cerebral hemispheres. At 40 days of age and older no effect was observed. This inhibition was a delayed phenomenon, dose-dependent and with no recovery. It is proposed that the inhibition of enzyme formation is related to radiation damage caused to DNA. Actinomycin D inhibited the development of glycerol phosphate dehydrogenase in a manner similar to ionizing radiation. Four other dehydrogenases also showed age-dependent radiosensitivities. ‘Malic enzyme’ (EC 1.1.1.40), lactate dehydrogenase (EC 1.1.1.27) and malate dehydrogenase (EC 1.1.1.37) ceased to be radiosensitive at about 8 days of age and isocitrate dehydrogenase (NADP) (EC 1.1.1.42) at 16 days. The correlation between developmental increase in enzyme activity and radiosensitivity held closely for glycerol phosphate dehydrogenase and isocitrate dehydrogenase and to a smaller extent for the others.

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confidence: 99%