Influence of parental weight change on the incidence of overweight and obesity in offspring

Fan, Hui; Zhang, Xingyu

doi:10.1186/s12887-022-03399-8

Cited by 6 publications

(6 citation statements)

References 30 publications

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“…Obesity is a complex disease influenced by genetics and environment, where parents play an important role in both aspects. In our study, children and adolescents with overweight parents were found to be nearly twice as likely to develop MHO and MUO as those with non-overweight parents, and the conclusion was similar to previous evidence including cross-sectional and longitudinal studies (43,44). On the one hand, parental obesity could predict similar obesity susceptibility in their children due to genetic background (45).…”

Section: Discussionsupporting

confidence: 91%

Sex differences in metabolically healthy and metabolically unhealthy obesity among Chinese children and adolescents

et al. 2022

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ObjectivesTo analyze sex differences in the prevalence of obesity phenotypes and their risk factors among children and adolescents aged 7-18 years in China.MethodsWe enrolled 15,114 children and adolescents aged 7-18 years into the final analysis. Obesity phenotypes were classified by body mass index (BMI) and metabolic status as metabolically healthy or unhealthy obesity. In addition, we collected four possible influencing factors on obesity phenotypes through questionnaires, including demographic, parental, early life, and lifestyle indicators. Multinomial logistic regression analysis in a generalized linear mixed model (GLMM) was selected to estimate the odds ratio (OR) and 95% confidence interval (95% CI) for identifying risk factors and control the cluster effects of schools. More importantly, the interaction terms of sex and each indicator were established to demonstrate the sex differences.ResultsThe prevalence of metabolically healthy obesity (MHO), metabolically unhealthy obesity (MUO), metabolically healthy overweight and obesity (MHOO), and metabolically unhealthy overweight and obesity (MUOO) were 3.5%, 5.6%, 11.1%, and 13.0% respectively, with higher prevalence in boys (5.3% vs. 1.6%, 7.9% vs. 3.1%, 14.3% vs. 7.7%, 15.6% vs. 10.1%). In addition, younger ages, single children, parental smoking, parental history of diseases (overweight, hypertension, diabetes), caesarean, premature, and delayed delivery time, high birth weight, insufficient sleep time, and excessive screen time were considered as important risk factors of MHO and MUO among children and adolescents (p < 0.05). More notably, boys were at higher risks of MUO when they were single children (boys: OR = 1.56, 95% CI: 1.24-1.96; girls: OR = 1.12, 95% CI: 0.82-1.54), while girls were more sensitive to MUO with parental smoking (girls: OR = 1.34, 95% CI: 1.02-1.76; boys: OR = 1.16, 95% CI: 0.97-1.39), premature delivery (girls: OR = 3.11, 95% CI: 1.59-6.07; boys: OR = 1.22, 95% CI: 0.67-2.22), high birth weight (girls: OR = 2.45, 95% CI: 1.63-3.69; boys: OR = 1.28, 95% CI: 0.96-1.70), and excessive screen time (girls: OR = 1.47, 95% CI: 1.06-2.04; boys: OR = 0.97, 95% CI: 0.79-1.20), with significant interaction term for sex difference (pinteraction < 0.05).ConclusionsMHO and MUO are becoming prevalent among Chinese children and adolescents. Significant sex differences in the prevalence of obesity phenotypes as well as their environmental and genetic risk factors suggest it might be necessary to manage obesity phenotypes problems from a sex perspective.

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Section: Discussionsupporting

confidence: 91%

Sex differences in metabolically healthy and metabolically unhealthy obesity among Chinese children and adolescents

et al. 2022

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“…Due to evident timing and ethical issues, human studies investigating these aspects are limited and varied; thus, this systematic review was carried out in order to summarize the state-of-the-art findings. The majority of included studies [22][23][24][27][28][29][30][31] considered BMI as paternal parameter on varying offspring outcomes. Four studies studied cord blood DNA methylation, all of which showed the impact of higher paternal BMI on DNA methylation of different genes.…”

Section: Discussionmentioning

confidence: 99%

“…Two studies assessed paternal BMI and birthweight showing that after adjustment for maternal age, smoking status, BMI of the other parent, the newborn's birth weight and gender, the infant birthweight increased by 42.2 g (95% CI 29.5-54.8; P < 0.0001) per unit increase in maternal pregravid BMI and 10.7 g (95% CI 0.5-20.9; P = 0.04) per unit increase in paternal pre-gravid BMI [29] and that a paternal BMI > 25 was associated with increased offspring birth weight compared with paternal BMI less than 25 (mean [SD] z score, 0.38 [0.91] vs 0.11 [0.96]; P = .004) [27]. Another study showed that paternal persistent overweight and obesity were also associated with higher risk of overweight and obesity in offspring at follow-up [23]. Interestingly, one study reported a significantly smaller infant triceps, suprailiac, and thigh skinfold thickness measurement, as well as percent fat mass, in offspring of fathers with a BMI >35 compared with that observed in offspring of lean fathers [22].…”

Section: Discussionmentioning

confidence: 99%

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Paternal nutrition: a neglected periconceptual influence on offspring health

Pizzol,

Gibson,

Muhelo

et al. 2023

Nutrire

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Increasing evidence suggests that paternal nutrition and nutritional status are potentially associated with offspring health. However, its specific configuration in the wider concept of trans-generational linkage and how it fits with genetic, epigenetic and environmental factors is unclear. Thus, the aim of this systematic review was to assess the effects of paternal nutrition or nutritional status on offspring health. This systematic review included 12 studies and a total of 8658 fathers and relative children. Paternal body mass index (BMI) was significantly related with cord blood DNA methylation, birthweight and obesity in offspring at follow-up, anthropometric measurements and obestatin and visfatin levels. Only one study investigated and showed an association between paternal river fish diet and lower risk of autism spectrum disorder. No association was reported in single studies between paternal intake of caffeine, folate vitamins B6 and B12 and offspring health outcomes. Limited data suggests that paternal nutrition and nutritional status are associated with components of offspring health. Considering this emerging concept, it is mandatory to reconsider the approach to fertility and offspring wellbeing, including fathers as a pivotal element. It is urgent to better understand how the male factor impacts couple fertility and offspring health outcomes. It is also crucial to ensure that, at conception, the father, as well as the mother, considers nutritional and lifestyle factors.

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“…10 Furthermore, parental obesity increases the risk of childhood obesity. 11 Eventually, by 2050, 60% of males and 50% of females will be obese. 12 This leads to an exponential increase in the worldwide incidence of NAFLD.…”

Section: Introductionmentioning

confidence: 99%

The bidirectional impacts of alcohol consumption and MAFLD for progressive fatty liver disease

Kulkarni¹,

Sarin

2023

Therapeutic Advances in Endocrinology

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Nonalcoholic fatty liver disease (NAFLD), once considered a benign condition, has been associated with several cardiometabolic complications over the past two decades. The worldwide prevalence of NAFLD is as high as 30%. NAFLD requires the absence of a “significant alcohol intake.” Conflicting reports have suggested that moderate alcohol consumption may be protective; therefore, the diagnosis of NAFLD previously relied on negative criteria. However, there has been a significant increase in alcohol consumption globally. Apart from the rise in alcohol-related liver disease (ARLD), alcohol, a major toxin, is associated with an increased risk of several cancers, including hepatocellular carcinoma. Alcohol misuse is a significant contributor to disability-adjusted life years. Recently, the term metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed instead of NAFLD to include the metabolic dysfunction responsible for the major adverse outcomes in patients with fatty liver disease. MAFLD, dependent on the “positive diagnostic criteria” rather than previous exclusion criteria, may identify individuals with poor metabolic health and aid in managing patients at increased risk of all-cause and cardiovascular mortality. Although MAFLD is less stigmatizing than NAFLD, excluding alcohol intake may increase the risk of already existing underreported alcohol consumption in this subgroup of patients. Therefore, alcohol consumption may increase the prevalence of fatty liver disease and its associated complications in patients with MAFLD. This review discusses the effects of alcohol intake and MAFLD on fatty liver disease.

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Influence of parental weight change on the incidence of overweight and obesity in offspring

Cited by 6 publications

References 30 publications

Sex differences in metabolically healthy and metabolically unhealthy obesity among Chinese children and adolescents

Sex differences in metabolically healthy and metabolically unhealthy obesity among Chinese children and adolescents

Paternal nutrition: a neglected periconceptual influence on offspring health

The bidirectional impacts of alcohol consumption and MAFLD for progressive fatty liver disease

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