Influence of p-coumaric acid on doxorubicin-induced oxidative stress in rat's heart

Abdel-Wahab, Mohamed H.; El‐Mahdy, Mohamed A.; Abd-Ellah, Mohamed F.; Helal, Gouda K.; Khalifa, Fares K.; Hamada, Farid M.A.

doi:10.1016/s1043-6618(03)00214-7

Cited by 136 publications

(71 citation statements)

References 35 publications

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“…The redox-cycle of DOX in the presence of cytochrome P450 reductase and NADPH was considered as the major source of hydrogen peroxide [3,23] . Recently, much attention has been focused on the protective effects of antioxidants and naturally occurring substances against DOX-induced cardiotoxicity [4,2] . Administration of SO before DOX treatment clearly attenuated the cardio toxicity; normalized oxidative stress markers such as MDA, P.carbonyl and restored the total antioxidant capacity.…”

Section: Resultsmentioning

confidence: 99%

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Sesame Oil as a Protective Agent Against Doxorubicin Induced Cardio Toxicity in Rat

Shad¹,

Al-Salam²,

Hamza³

2007

American J. of Pharmacology and Toxicology

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Abstract:The therapeutic value of doxorubicin (DXO) as anticancer antibiotic is limited by its cardiotoxicity. This study aimed to investigate the protective effect of sesame oil against DXO-induced cardiotoxicity and oxidative stress. The administration of DXO (20 mg/kg) to Wister male rats, increased serum aspartate aminotransferase and creatine kinase activities (as cardiotoxicity indices) as well as cardiac malondialdehyde and protein carbonyl contents and catalase activity (as markers of oxidative stress). The cardiotoxicity damage in DOX treated rats was accompanied by histo pathological changes such as necrosis and apoptosis in cardiac tissues. These biochemical and histological disturbances were effectively attenuated on pretreatment with sesame oil (5ml/kg). These data suggest that sesame oil may be a suitable cardio protector during DOX treatment.

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Section: Resultsmentioning

confidence: 99%

“…In fact, several compounds with antioxidant properties have been investigated with some degree of success. These include p-coumaric acid [4] , garlic acid [2] , erdosteine [5] and carvedilol [1] . Sesame Oil (SO) is extract from the plant Sesamum indicum (HS), family: Pedaliaceae [6] .…”

Section: Doxorubicinmentioning

confidence: 99%

Sesame Oil as a Protective Agent Against Doxorubicin Induced Cardio Toxicity in Rat

Shad¹,

Al-Salam²,

Hamza³

2007

American J. of Pharmacology and Toxicology

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“…Several publications have emphasized valuable therapeutic and also cosmetic properties of p-coumaric acid, e.g. its antioxidant and antigenotoxic effects, and its potential usefulness as a hypopigmenting agent (Abdel-Wahab et al 2003;An et al 2010;Ferguson et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Production of biologically active phenolic acids in Aronia melanocarpa (Michx.) Elliott in vitro cultures cultivated on different variants of the Murashige and Skoog medium

Szopa

2013

Plant Growth Regul

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Phenolic acids, both benzoic and cinnamic acid derivatives, are plant metabolites with high therapeutic and cosmetic values. Methanolic extracts from the biomass of shoot and callus cultures of Aronia melanocarpa growing on seven variants of the Murashige and Skoog (MS) medium with different concentrations of plant growth regulators, BA and NAA, ranging from 0.1 to 3.0 mg l -1 , were examined for the production of free phenolic acids and cinnamic acid using the high-performance liquid chromatography (HPLC) method. The extracts from the shoot and callus cultures were confirmed to contain five of the twelve compounds tested for: caffeic, p-coumaric, p-hydroxybenzoic, syringic and vanillic acids. The shoot extracts contained additionally salicylic acid. Both the total amounts and the amounts of individual compounds in either the shoot or callus extracts were dependent on the concentration of cytokinin and auxin in the MS medium variants. The total amounts in the shoot and callus cultures were in the range from 93.52 to 217.00 mg 100 g -1 DW and from 47.11 to 83.83 mg 100 g -1 DW, respectively. The amounts of individual compounds showed wide variation, from 1.31 to 91.86 mg 100 g -1 DW in the shoot extracts, and from 2.58 to 40.16 mg 100 g -1 DW in the callus extracts. Salicylic acid (max. 91.86 mg 100 g -1 DW), p-coumaric acid (max. 62.39 mg 100 g -1 DW) and p-hydroxybenzoic acid (max. 50.66 mg 100 g -1 DW) dominated in the shoot extracts, while syringic acid (max. 40.16 mg 100 g -1 DW) and p-hydroxybenzoic acid (max. 23.59 mg 100 g -1 DW) were the main metabolites in the callus extracts. This is the first report on the quantitative analysis of benzoic and cinnamic acid derivatives in shoot and callus cultures of A. melanocarpa growing on MS-based media with different concentrations of selected plant growth regulators-BA and NAA. The obtained maximum amounts of some metabolites are of interest from a practical perspective.

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“…These compounds exhibit numerous biological activities, the most important of which are their immunostimulating, antioxidant and anticancer properties (Abdel-Wahab et al 2003;De Graff et al 2003;Ekiert and Czygan 2007;Nakamura et al 2001;Sroka and Cisowski 2003). Linear furanocoumarins have an established position in therapy as antiproliferative and photosensitizing agents, and some of them are calcium and potassium channel blockers (Bohuslavizki et al 1994;Ekiert and Czygan 2007).…”

Section: Introductionmentioning

confidence: 99%

Production of bioactive phenolic acids and furanocoumarins in in vitro cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams. under different light conditions

Szopa

Ekiert

Szewczyk

et al. 2012

Plant Cell Tiss Organ Cult

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Influence of p-coumaric acid on doxorubicin-induced oxidative stress in rat's heart

Cited by 136 publications

References 35 publications

Sesame Oil as a Protective Agent Against Doxorubicin Induced Cardio Toxicity in Rat

Sesame Oil as a Protective Agent Against Doxorubicin Induced Cardio Toxicity in Rat

Production of biologically active phenolic acids in Aronia melanocarpa (Michx.) Elliott in vitro cultures cultivated on different variants of the Murashige and Skoog medium

Production of bioactive phenolic acids and furanocoumarins in in vitro cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams. under different light conditions

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