Influence of oxygen on the biosynthesis of polyunsaturated fatty acids in microalgae

Sun, Xiao‐Man; Geng, Lingjun; Ren, Lu‐Jing; Ji, Xiao‐Jun; Ning, Hao; Chen, Kequan; Huang, He

doi:10.1016/j.biortech.2017.11.005

Cited by 88 publications

(33 citation statements)

References 113 publications

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“…On the aerobic pathway when molecular oxygen is present, saturated fatty acids react with desaturase and elongase enzymes which results in formation of PUFAs. On the anaerobic pathway, de novo synthesis of PUFAs for desaturases occurs through biosynthesis by polyketide synthase (PKS) 6,16 .…”

Section: Introductionmentioning

confidence: 99%

Production of Polyunsaturated Fatty Acids and Lipids from Autotrophic, Mixotrophic and Heterotrophic cultivation of Galdieria sp. strain USBA-GBX-832

López

Yate

Ramos

et al. 2019

Sci Rep

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A search for extremophile organisms producing bioactive compounds led us to isolate a microalga identified as Galdieria sp. USBA-GBX-832 from acidic thermal springs. We have cultured Galdieria sp. USBA-GBX-832 under autotrophic, mixotrophic and heterotrophic conditions and determined variations of its production of biomass, lipids and PUFAs. Greatest biomass and PUFA production occurred under mixotrophic and heterotrophic conditions, but the highest concentration of lipids occurred under autotrophic conditions. Effects of variations of carbon sources and temperature on biomass and lipid production were evaluated and factorial experiments were used to analyze the effects of substrate concentration, temperature, pH, and organic and inorganic nitrogen on biomass production, lipids and PUFAs. Production of biomass and lipids was significantly dependent on temperature and substrate concentration. Greatest accumulation of PUFAs occurred at the lowest temperature tested. PUFA profiles showed trace concentrations of arachidonic acid (C 20:4 ) and eicosapentaenoic acid (C 20:5 ). This is the first time synthesis of these acids has been reported in Galdieria . These findings demonstrate that under heterotrophic conditions this microalga’s lipid profile is significantly different from those observed in other species of this genus which indicates that the culture conditions evaluated are key determinants of these organisms’ responses to stress conditions and accumulation of these metabolites.

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Section: Introductionmentioning

confidence: 99%

Production of Polyunsaturated Fatty Acids and Lipids from Autotrophic, Mixotrophic and Heterotrophic cultivation of Galdieria sp. strain USBA-GBX-832

López

Yate

Ramos

et al. 2019

Sci Rep

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show abstract

“…Microalgae, as photosynthetic organisms, are subjected to elevated concentrations of reactive oxygen species (ROS) and have developed a mechanism to protect themselves from the free radicals. The produced antioxidants are the mechanism's foundation, preventing cell damage by preventing ROS accumulation in the microalgae [80]. Given biodiversity of microalgae, easy cultivation, and growth modulation, they can be considered among the top natural resources with outstanding antioxidant potential [81].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Microalgae: Cultivation Aspects and Bioactive Compounds

Coelho

Tundisi

Cerqueira

et al. 2019

Braz. arch. biol. technol.

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Microalgae are aquatic unicellular microorganisms that can be found both in freshwater and marine systems; are capable of photosynthesis; and can grow as individual cells or associated in chains or small colonies. Microalgae cultivation has gained large momentum among researchers in the past decades due to their ability to produce value metabolites, remarkable photosynthetic efficiency, and versatile nature. The wide technological potential, and thus increasing amount of scattered knowledge, may become the very first barrier that a post graduating student, or any non-specialist reader, will face when introduced to the subject. In this review paper, we access the core aspects of microalgae technology, covering their main characteristics, and comprehensively presenting the main features of their various cultivation modes and biological activity from metabolites.

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“…This allows for a better control of the oxygen level in the reactor, which can be used to create conditions that stimulate accumulation of high-value compounds, for instance, anti-inflammatory PUFA. Indeed, oxygen concentration has been found to greatly influence the accumulation of value compounds in microalgae [122]. The accumulation of anti-inflammatory compounds in microalgae, such as specific PUFA and carotenoids, can be induced under low oxygen supply.…”

Section: Surfactant-facilitated Accumulation Of Anti-inflammatory mentioning

confidence: 99%

Chemically-Induced Production of Anti-Inflammatory Molecules in Microalgae

et al. 2018

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Microalgae have been widely recognized as a valuable source of natural, bioactive molecules that can benefit human health. Some molecules of commercial value synthesized by the microalgal metabolism have been proven to display anti-inflammatory activity, including the carotenoids lutein and astaxanthin, the fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), and sulphated polysaccharides. These molecules can accumulate to a certain extent in a diversity of microalgae species. A production process could become commercially feasible if the productivity is high and the overall production process costs are minimized. The productivity of anti-inflammatory molecules depends on each algal species and the cultivation conditions, the latter being mostly related to nutrient starvation and/or extremes of temperature and/or light intensity. Furthermore, novel bioprocess tools have been reported which might improve the biosynthesis yields and productivity of those target molecules and reduce production costs simultaneously. Such novel tools include the use of chemical triggers or enhancers to improve algal growth and/or accumulation of bioactive molecules, the algal growth in foam and the surfactant-mediated extraction of valuable compounds. Taken together, the recent findings suggest that the combined use of novel bioprocess strategies could improve the technical efficiency and commercial feasibility of valuable microalgal bioproducts production, particularly anti-inflammatory compounds, in large scale processes.

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Influence of oxygen on the biosynthesis of polyunsaturated fatty acids in microalgae

Cited by 88 publications

References 113 publications

Production of Polyunsaturated Fatty Acids and Lipids from Autotrophic, Mixotrophic and Heterotrophic cultivation of Galdieria sp. strain USBA-GBX-832

Production of Polyunsaturated Fatty Acids and Lipids from Autotrophic, Mixotrophic and Heterotrophic cultivation of Galdieria sp. strain USBA-GBX-832

Microalgae: Cultivation Aspects and Bioactive Compounds

Chemically-Induced Production of Anti-Inflammatory Molecules in Microalgae

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