Influence of oxidative stress and metabolic adaptation on PON1 activity and MDA level in transition dairy cows

Turk, Romana; Juretić, Dubravka; Gereš, Darko; Svetina, Ante; Turk, Nenad; Flegar-Meštrić, Zlata

doi:10.1016/j.anireprosci.2007.07.012

Cited by 86 publications

(92 citation statements)

References 27 publications

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“…Transition phase from early lactation period to late lactation period is regulated by a homeostatic mechanism comprising metabolic interactions and body fuel distribution, and this mechanism is primarily based on glucose 26 . Turk et al 28 reported that in lactating cow serum glucose concentrations were in low levels in early lactation period and these levels increased towards to the middle of the lactation period. In early lactation period, non-esterified fat acids (NEFA), which form as the result of lipid mobilization, are used to meet energy need 27,28 .…”

Section: Discussionmentioning

confidence: 99%

“…Turk et al 28 reported that in lactating cow serum glucose concentrations were in low levels in early lactation period and these levels increased towards to the middle of the lactation period. In early lactation period, non-esterified fat acids (NEFA), which form as the result of lipid mobilization, are used to meet energy need 27,28 . It has been stated that free radical level will also be higher because of NEFA oxidation that increases in hepatocyte mitochondrium 29 .…”

Section: Discussionmentioning

confidence: 99%

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Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri

Karapehlivan¹,

Kaya²,

Sağ³

et al. 2013

Kafkas Univ Vet Fak Derg

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SummaryThe purpose of the study was to investigate effects on oxidant and antioxidant balance of early and late lactation period in goats. Blood samples used in study were obtained from Halep goats in early and late lactation period. Oxidative stress index (OSI) and lipid hydroperoxide (LOOH) and total oxidative status (TOS) and total antioxidant status (TAS) were analyzed to determined of oxidant and antioxidant balance. Plasma TOS, OSI and LOOH levels in early lactation period were significantly higher (P<0.001) than late lactation period of goats, while lower (P<0.001) level of TAS. It was concluded that lipid peroxidation decreased and antioxidant defence system mechanism in late lactation period in goats served as more positive than early lactation period. Keywords: Goat, Lactation, Total antioxidant status, Total oxidant status, Oxidative stress Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri ÖzetBu çalışmada keçilerin oksidan ve antioksidan dengesi üzerinde erken ve geç laktasyon periyodunun etkilerinin araştırılması amaçlandı. Çalışmada kullanılan kan örnekleri erken ve geç laktasyon periyodunda bulunan Halep keçilerinden elde edildi. Oksidan ve antioksidan dengenin değerlendirilmesi için oksidatif stres indeksi (OSİ), lipid hidroperoksid (LOOH), total oksidan (TOS) ve total antioksidan düzeyleri (TAS) analiz edildi. Erken laktasyon periyodunda plazma TOS, OSİ ve LOOH düzeylerinin geç laktasyon periyodundaki keçilere göre daha yüksek (P<0.001) olduğu belirlenirken, TAS düzeyinin daha düşük olduğu belirlendi (P<0.001). Sonuç olarak, geç laktasyon periyodundaki keçilerde erken laktasyon periyoduna göre lipid peroksidasyonunun azaldığı ve antioksidan savunma sistemi mekanizmasının daha olumlu yönde işlediği kanısına varıldı.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri

Karapehlivan¹,

Kaya²,

Sağ³

et al. 2013

Kafkas Univ Vet Fak Derg

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“…In spite of the activity of preventive enzymes, some ROS may remain and cause deleterious effect on macromolecules. In this situation, there are some other antioxidant enzymes that are chain-breaking and inhibit oxidative damage of macromolecules such as paraoxonase-1 (PON1), platelet-activating factor acetylhydrolase (PAF-AH) and lecitin:cholesterol acyltransferase (LCAT) that prevent and retard oxidative modification of lipoproteins (Parthasarathy et al, 1990;Turk et al, 2005Turk et al, , 2008a. Chainbreaking antioxidants act after the initiation of chain reaction with ROS.…”

Section: Antioxidantive Systemmentioning

confidence: 99%

“…Majority of them are released by any biochemical redox reaction which includes oxygen (Devasagayam et al, 2004). Depending of concentration, ROS may be useful or harmful to cells and tissues (Mittler, 2002;Turk et al, 2008a). If the capability of an organism to eliminate ROS by means of antioxidants fails, ROS damages proteins, lipids and DNA and induce oxidative stress (Sanz, 2016).…”

Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

The role of oxidative stress and inflammatory response in the pathogenesis of mastitis in dairy cows

Turk

2017

Mljekarstvo

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Mastitis is one of the most frequent diseases of dairy cows throughout the world, therefore it causes the greatest economic losses in dairy cattle industry. These losses are reflected through: reduced milk production, increased costs of medication and the other animal health services, reduced fertility, early culling of animals and the value of discarded milk. Mastitis is also important from the aspects of public health, milk processing and animal welfare. In the pathogenesis of mastitis the key role plays the innate immune response which is the first line of defence against the pathogen invasion of the udder. The innate immune response generates an inflammatory reaction which is the elementary response of an organism to the tissue trauma induced by any physical, chemical or biological causative agent, but primarily it is the protective mechanism of a vital significance which includes increased phagocytic activity, secretion of antimicrobial substances, fibrosis as well as the alterations in tissue structure of affected organ or body cavity. The release of a number of inflammatory mediators as well as reactive oxygen species (ROS) is an important part of inflammatory response. In dairy cows, the metabolic challenge that occurred during the transition from dry period to early lactation may additionally increase the release of ROS which may contribute to development of oxidative stress and inflammatory response. Oxidative stress is defined as a shift in the balance from cellular oxidation-reduction reactions towards oxidation, i.e. to the state of excessive release of oxidants when their removal by antioxidants is impaired and even insufficient. During peripartum period antioxidantive status of dairy cows is seriously impaired and consequently both the oxidative stress and inflammatory response may present the predisposing factors to their higher susceptibility to intramammary infections (IMI) and mastitis. This association between oxidative stress and inflammation during IMI and mastitis indicates their role in the pathogenesis of mastitis. Thus, a better understanding of such a synergism could contribute to development of new approaches to prevention and therapy of IMI and mastitis.

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“…Both in human and cow serums tightly bonded to apolipoprotein of PON-1 HDL-C it circulates as component of HDL-C. PON-1 composed of lipoproteins (HDL and LDL) is defined as a protective marker against development of lipid peroxidation and oxidative stress (Bademkıran 2008;Juretic et al 2001;Turk et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Paraoxonase activity an indicator of complications at early stage of complicated pregnant cows

NazliErcan

Yokuş

Kochan

2017

IJAR

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In healthy and complicated pregnant cows, on the 2 nd and 6 th months of pregnancy in order to determine the levels of maternal serum Paraoxonase 1 (PON1) activity and the possibility of complications can occur during the pregnancy might be a premise indication. Serum samples were taken at 2 nd and 6 th months of 252 pregnant cows at the end of their pregnancies. The cows were classified into two groups such as complicated (Abortion, Dystocia) and non-complicated. Maternal serum PON1 activity in 6 th months was lower at complicated group than normally pregnant group (P=0.004; P<0.01), no difference was discovered between these groups in their 2 nd month of pregnancy (P>0.05). Among the concentration of HDL, TP and globulin no statistical difference was observed between complicated, subgroups and normal births (P>0.05). Levels of PON1 in 2 and 6 months were statistically different between the groups of dystocia and normal pregnancy (P<0.01; P = 0.003), and abort and normal pregnancy (P<0.05; P=0.033). In this study, it was inferred that the evaluation of PON1 activity early indicator of complications for clinicians that might occur in further periods of pregnancy. These results showed the fact that PON1 activity can be used as a marker relatively at the early phases of pregnancy in complicated cows.

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Influence of oxidative stress and metabolic adaptation on PON1 activity and MDA level in transition dairy cows

Cited by 86 publications

References 27 publications

Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri

Erken ve Geç Laktasyon Periyodunun Keçilerde Plazma Oksidan/Antioksidan Dengesi Üzerindeki Etkileri

The role of oxidative stress and inflammatory response in the pathogenesis of mastitis in dairy cows

Paraoxonase activity an indicator of complications at early stage of complicated pregnant cows

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