Influence of Ovariectomy in the Right Ventricular Contractility in Heart Failure Rats

Giuberti, Karina; Pereira, Raquel Binda; Bianchi, Patricia Rocon; Paigel, A. S.; Vassallo, Dalton Valentim; Stefanon, Ivanita

doi:10.1016/j.arcmed.2006.09.015

Cited by 11 publications

(6 citation statements)

References 29 publications

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“…24 Ovariectomy had no significant effect on right ventricular contractility but did slow ventricular relaxation rate in Wistar rats. 25 Thus, the elevated MCFP recorded in OVX SHR may be necessary to maintain venous return and cardiac filling in the face of elevated resistance to venous return or reduced cardiac compliance or contractility.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ovariectomy on Blood Pressure and Venous Tone in Female Spontaneously Hypertensive Rats

Martin

Redetzke

Vogel

et al. 2008

American Journal of Hypertension

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Section: Discussionmentioning

confidence: 99%

Effect of Ovariectomy on Blood Pressure and Venous Tone in Female Spontaneously Hypertensive Rats

Martin

Redetzke

Vogel

et al. 2008

American Journal of Hypertension

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“…In rats, the progression to CHF after MI is attenuated in females compared with males. 6,27 Mice demonstrate a similar sexdependent response to MI, such that male hearts rupture more readily and have significantly poorer left ventricular function, more prominent dilation, and significant myocyte hypertrophy compared with females. 28 This is further validated in salt-sensitive Dahl rats that develop hypertension and significant hypertrophy when fed a high-salt diet.…”

Section: Sex and Rodent Models Of Chfmentioning

confidence: 99%

The Effects of Biological Sex and Diet on the Development of Heart Failure

Konhilas

Leinwand

2007

Circulation

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“…Estrogen has protective effects on the pulmonary vasculature and improves RV contractility in animals (2)(3)(4). Testosterone has been shown to be a pulmonary vasodilator, yet has unclear effects on pulmonary endothelium (5,6).…”

mentioning

confidence: 99%

Sex Hormones Are Associated with Right Ventricular Structure and Function

Ventetuolo¹,

Ouyang²,

Bluemke³

et al. 2011

Am J Respir Crit Care Med

152

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Rationale: Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown. Objectives: We hypothesized that sex hormones would be associated with RV morphology in a large cohort free of cardiovascular disease. Methods: Sex hormones were measured by immunoassay and RV ejection fraction (RVEF), stroke volume (RVSV), mass, end-diastolic volume, and end-systolic volume (RVESV) were measured by cardiac magnetic resonance imaging in 1,957 men and 1,738 postmenopausal women. The relationship between each hormone and RV parameter was assessed by multivariate linear regression. Conclusions: Higher estradiol levels were associated with better RV systolic function in women using hormone therapy. Higher levels of androgens were associated with greater RV mass and volumes in both sexes.Keywords: sex; sex hormones; right ventricle Sex differences in atherosclerosis and congestive heart failure (CHF) have been well described, with women experiencing a significant lag in the onset of coronary artery disease and lower rates of CHF compared with men (1). Estrogen, testosterone, dehydroepiandrosterone (DHEA), and sex hormone-binding globulin (SHBG) have important, albeit controversial, roles in left ventricular (LV) function and systemic vascular disease, whereas the effects of sex hormones on right ventricular (RV) and pulmonary vascular function are unknown.Estrogen has protective effects on the pulmonary vasculature and improves RV contractility in animals (2-4). Testosterone has been shown to be a pulmonary vasodilator, yet has unclear effects on pulmonary endothelium (5, 6). Treatment with DHEA prevents pulmonary vascular changes and RV hypertrophy, and prolongs survival in animal models of pulmonary hypertension (PH) (7,8). SHBG is expressed in myocytes of failing human hearts and in murine fetal lung epithelium, but its role in pulmonary vascular function has not been studied (9, 10).Despite the beneficial effects of estrogen on the pulmonary vasculature, female sex is the best established clinical risk factor for idiopathic pulmonary arterial hypertension (PAH) (11). Yet, women have higher RV ejection fraction (RVEF) and improved survival compared with men with PAH (12-14). In systemic cardiovascular disease, an individual's estrogen:testosterone balance may be more predictive of disease risk than either hormone alone (15,16). Last, it is unknown how sex hormones affect the interaction of the RV with the pulmonary vasculature, particularly in individuals with no known (or subclinical) PH.We examined the cross-sectional association of serum estradiol (E2), bioavailable testosterone (bioT), DHEA, SHBG, and the E2:testosterone ratio (E2:T) with RV structure and function assessed by cardiac magnetic resonance imaging (MRI) in a large AT A GLANCE COMMENTARY Scientific Knowledge on the SubjectFemale sex is a risk factor for the development of pulmonary hypertension (PH), yet women appear to have better right ventricular (RV) function and improved survival compared to men with PH....

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Influence of Ovariectomy in the Right Ventricular Contractility in Heart Failure Rats

Cited by 11 publications

References 29 publications

Effect of Ovariectomy on Blood Pressure and Venous Tone in Female Spontaneously Hypertensive Rats

Effect of Ovariectomy on Blood Pressure and Venous Tone in Female Spontaneously Hypertensive Rats

The Effects of Biological Sex and Diet on the Development of Heart Failure

Sex Hormones Are Associated with Right Ventricular Structure and Function

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