Influence of Oryzanol and Ferulic Acid on the Lipid Metabolism and Antioxidative Status in High Fat-Fed Mice

Abstract

The comparative effects of oryzanol and ferulic acid on the lipid metabolism and antioxidative status of high fat-fed mice were investigated. The mice were given a diet containing 17% fat (HF), supplemented with oryzanol (HF-O) or ferulic acid for 7 weeks. The control mice (NC) were fed with normal diet. The HF mice exhibited increased body weight gain, plasma and hepatic total cholesterol and triglyceride concentrations, and lipid peroxidation rate, and reduced high-density lipoprotein cholesterol level. In general, they also showed lower hepatic antioxidant and higher lipid-regulating enzymes activities relative to that of NC group. Addition of oryzanol or ferulic acid in the diet counteracted these high fat-induced hyperlipidemia and oxidative stress via increased faecal lipid excretion and regulation of antioxidant and lipogenic enzymes activities. This study illustrates that oryzanol and ferulic acid have relatively similar hypolipidemic actions and could be effective in lowering the risk of high fat diet-induced obesity.

Isolation, characterization and hypolipidemic activity of ferulic acid in high-fat-diet-induced hyperlipidemia in laboratory rats

“…In the present study, serum VLDL levels were notably raised in HFD control group, whereas FA treatment significantly decreased the level of VLDL. Finding of our investigation is in line with the results of previous studies which showed that administration of reduced plasma triglyceride, free fatty acid, and total cholesterol in diabetic rats (Jin Son et al, 2010[20]; Sri Balasubashini et al, 2003[46]). Furthermore, FA has an ability to inhibit cholesterol synthesis via competitive inhibition of HMG-CoA reductase (Kim et al, 2003[30]).…”

Germinated Pigmented Rice (Oryza Sativa L. cv. Superhongmi) Improves Glucose and Bone Metabolisms in Ovariectomized Rats

“…In the present study, γ-oryzanol, GABA, phytic acid, tocols, and policosanol were significantly higher in a germinated rice sample than that of the non-germinated one. γ-oryzanol, GABA, and phytic acid have hypolipidemic, hypoglycemic, and anti-obesity effects [4,7,37,38,39]. The tocols and policosanol possess antioxidative and antidiabetic property [4,40,41].…”

Antioxidant Activity of γ-Oryzanol: A Complex Network of Interactions

“…In addition, Orz and FA are able to improve the plasma and hepatic lipid profile by increasing faecal lipid excretion [14]. The available evidence suggests that intakes of 1.5–2.0 g of plant sterols may lower blood LDL-cholesterol by an average of 8.5%–10% [56,57].…”