Influence of orange juice in the levels and in the genotoxicity of iron and copper

Mineral content is related to antioxidant and antimutagenic properties of grape juice

“…When considering only white grape juices, a negative correlation was noted between antimutagenic activity (hom locus) and Si, S, and Mg contents. A positive correlation was observed between antimutagenic activity (lys locus) and Zn content (R = 0.741, P < 0.05), antimutagenic activity (his locus) and Mg content (R = 0.781, P < 0.05), and antimutagenic activity (hom locus) and Cu content (R = 0.781, P < 0.05) ( A previous study on orange juices (Franke et al, 2006) showed that Cu content was negatively correlated with DNA damage. In addition, Zn has been reported to be a component of more than 70 different enzymes with various functions in cell metabolism involving the metabolism of proteins, lipids, and carbohydrates (Parkin, 2004); it has also been reported to possess antioxidant activity and decrease ROS production (Jemai et al, 2007).…”

Alzheimer’s Disease and Metal Contamination: Aspects on Genotoxicity

“…Mutagenic potential of metallic agents used in dietary supplementation, including iron sulfate, was also investigated by means of the comet assay. The authors reported a genotoxic effect of this metal in mouse blood cells after 24 h of treatment, at all tested concentrations (Franke et al, 2006). Genotoxic effects of Fe were also reported by Garry et al (2003) in rats treated with iron oxide (Fe 2 O 5 ) for 24 h. They observed that this metal only showed mutagenic potential when the animals were simultaneously treated with benzopyrene.…”

Recognition memory and DNA damage in undernourished young rats

“…The Comet Assay of blood and hippocampus cells was performed according to Tice et al (2000) and Franke et al (2006). Slides pre-coated with agarose were used.…”