Influence of oral moisturizing jelly as a saliva substitute for the relief of xerostomia in elderly patients with hypertension and diabetes mellitus

Dalodom, Supranee; Lam‐ubol, Aroonwan; Jeanmaneechotechai, Sutha; Takamfoo, Lalana; Intachai, Watanyoo; Duangchada, Kochaporn; Hongsachum, Buakhao; Kanjanatiwat, Panitnart; Vacharotayangul, Piamkamon; Trachootham, Dunyaporn

doi:10.1016/j.gerinurse.2015.10.014

Cited by 28 publications

(51 citation statements)

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“…Exclusion criteria included patients with mucositis grade ≥1 or with oral infection, such as candidiasis. The subjects were considered xerostomic when subjective dry mouth scores were ≥3 according to our previous study (Dalodom et al, ) and as described below.…”

Section: Methodsmentioning

confidence: 99%

“…Subjective dry mouth scores were obtained by interviewing the subjects according to a validated questionnaire used previously by our group (Dalodom et al, ). Briefly, the subjects were asked by one researcher to grade their problems from a scale of 0–10.…”

Section: Methodsmentioning

confidence: 99%

“…After collection, the saliva pH was measured by using pH indicator strip (Merck). A pH of less than 6.8 was considered acidic (Dalodom et al, 2016). Buffering capacity was measured using Ericsson's method as previously described with modification (Ericson & Bratthall, 1989).…”

Section: Salivary Flow Rates Ph and Buffering Capacitymentioning

confidence: 99%

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Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

et al. 2019

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Objectives To evaluate (a) oral colonization of Candida species, especially for non‐albicans Candida species (NACS), in xerostomic postradiotherapy head and neck cancer patients and (b) risk factors affecting their colonization. Materials and methods Subjective and objective dry mouth scores, stimulated salivary flow rates, pH and buffering capacity were measured in 72 xerostomic postradiotherapy head and neck cancer patients. Candida counts and species identification were performed using oral rinse samples cultured in Candida Chromagar, followed by polymerase chain reaction and API 20C AUX system. Results Candida colonization was observed in 87.5% of subjects, with 80.6% and 48.6% of study population colonized by C. albicans and NACS, respectively. NACS was associated with high objective dry mouth scores, denture use, and females (p = .006, .009, and .036, respectively). In addition, Candida glabrata was detected more in females (p = .018) and denture wearers (p = .026), while Candida tropicalis was associated with high objective dry mouth scores (p = .022) and females (p = .027). Quantity of Candida colonization correlated positively with objective dry mouth scores (r = 0.599, p < .001) and negatively with salivary flow rates (r = −0.258, p = .041) and pH (r = −0.290, p = .022). Conclusion NACS colonization was common in xerostomic head and neck cancer patients. Increased signs of dry mouth, female and dental prostheses may promote NACS colonization.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

et al. 2019

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“…The product can be swallowed from oral cavity through oropharynx which resembles natural saliva. A previous study in xerostomic elderly patients with hypertension and diabetes mellitus showed that continuous intake of OMJ for 4 weeks significantly reduced signs and symptoms of dry mouth, and achieved more than 80% satisfaction [13]. Recently, DIF have produced a new version of OMJ.…”

Section: Introductionmentioning

confidence: 99%

Alleviation of dry mouth by saliva substitutes improved swallowing ability and clinical nutritional status of post-radiotherapy head and neck cancer patients: a randomized controlled trial

Nuchit

Lam‐ubol

Paemuang

et al. 2019

Support Care Cancer

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The aim of this study is to investigate the effect of an edible saliva substitute, oral moisturizing jelly (OMJ), and a topical saliva gel (GC) on dry mouth, swallowing ability, and nutritional status in post-radiotherapy head and neck cancer patients. Methods Sixty-two post-radiation head and neck cancer patients with xerostomia completed a blinded randomized controlled trial. They were advised to swallow OMJ (n = 31) or apply GC orally (n = 31) for 2 months. Outcome measures were assessed at baseline, 1, and 2 months, including subjective and objective dry mouth (Challcombe) scores, subjective swallowing problem scores (EAT-10), water swallowing time, clinical nutritional status (PG-SGA), body weight, and dietary intake. Results After 1 and 2 months of interventions, subjective and objective dry mouth scores, subjective swallowing problem scores, swallowing times, and clinical nutritional status in both groups were significantly improved (p < 0.0001). Compared to GC, OMJ group had higher percent improvement in all outcome measures (p < 0.001) except swallowing time and clinical nutritional status. Interestingly, subjective dry mouth scores were significantly correlated with subjective swallowing problem scores (r = 0.5321, p < 0.0001). Conclusions Continuous uses of saliva substitutes (OMJ or GC) for at least a month improved signs and symptoms of dry mouth and enhanced swallowing ability. An edible saliva substitute was superior to a topical saliva gel for alleviating dry mouth and swallow problems. These lead to improved clinical nutritional status. Thus, palliation of dry mouth may be critical to support nutrition of post-radiotherapy head and neck cancer patients. Clinical trial registry Clinicaltrials.gov NCT03035825 Keywords Dysphagia. Xerostomia. Saliva substitute. Nutritional status. Head and neck cancer. Radiation therapy Abbreviations BIA Bioelectrical impedance assessment BMI Body mass index EAT-10 Eating Assessment Tool OMJ Oral moisturizing jelly PG-SGA Patient Generate-Subjective Global Assessment WST Water swallowing test Electronic supplementary material The online version of this article (

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“…The elderly also undergo aging processes which can be aggravated by chronic diseases, such as cardio‐ and cerebrovascular, diabetes, oral cancer, osteoporosis, as well as Parkinson's and Alzheimer's disease that are common in this age group . In terms of oral diseases, this group of patients may have an increased risk of developing cervical caries, periodontitis, xerostomia, and oral candidiasis …”

Section: Introductionmentioning

confidence: 99%

Aging effects in the expression of macrophages in post‐treatment apical periodontitis lesions

Almeida

Brasil

Ferreira

et al. 2017

Special Care in Dentistry

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Influence of oral moisturizing jelly as a saliva substitute for the relief of xerostomia in elderly patients with hypertension and diabetes mellitus

Cited by 28 publications

References 24 publications

Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

Alleviation of dry mouth by saliva substitutes improved swallowing ability and clinical nutritional status of post-radiotherapy head and neck cancer patients: a randomized controlled trial

Aging effects in the expression of macrophages in post‐treatment apical periodontitis lesions

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