Influence of Oral Atropine or Hyoscine on the Absorption of Oral Diazepam

Abstract

The influence of oral atropine or hyoscine on the absorption of oral diazepam administered at the same time was studied in eight volunteers using a three-way crossover randomized double-blind design. No difference was found in the timing of sedation or in the degree of sedation after diazepam alone or in combination with the anticholinergics. Diazepam serum concentrations were not significantly different after the three regimens. It is concluded that the anticholinergics can be given with diazepam for oral premedication without interfering with diazepam absorption.