“…Gilard et al [7] first highlighted the negative impact of PPIs and, in particular, omeprazole on the pharmacodynamic clopidogrel response, possibly owing to inhibition of CYP2C19, and this group further confirmed this drug-drug interaction by carrying out the randomized and double-blinded Omeprazole CLopidogrel Aspirin study [8]. Since then, however, other groups have shown that this response may not be relevant to all PPIs.…”