Influence of obstetric complication severity on brain morphology in schizophrenia: an MR study

Bersani, Giuseppe; Quartini, Adele; Manuali, Giorgiana; Iannitelli, Angela; Pucci, Daniela; Conforti, Filippo; Biasi, C. Di; Gualdi, Gian Franco

doi:10.1007/s00234-009-0501-3

Cited by 13 publications

(5 citation statements)

References 38 publications

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“…In accordance with our findings, Bersani and colleagues reported no effect of OCs on the bicaudate ratio (an indirect measure of caudate/ventricle size) in (n=47) male schizophrenia patients (Bersani et al, 2009).…”

Section: Effects Of Ocs On Brain Morphologysupporting

confidence: 93%

No effect of obstetric complications on basal ganglia volumes in schizophrenia

Haukvik

McNeil

Nesvåg

et al. 2010

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Section: Effects Of Ocs On Brain Morphologysupporting

confidence: 93%

No effect of obstetric complications on basal ganglia volumes in schizophrenia

Haukvik

McNeil

Nesvåg

et al. 2010

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Etiological associations with prenatal exposure to infection, 8 9 obstetric complications, 10 and genetic vulnerabilities 11 12 support the notion that schizophrenia has a neurodegenerative etiology. In addition, cortical gray matter loss has been shown to be associated with childhood-onset schizophrenia.…”

Section: Introductionmentioning

confidence: 75%

Neuroprotection in Schizophrenia and Its Therapeutic Implications

Kim

Lee

2017

Psychiatry Investig

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Schizophrenia is a chronic and debilitating mental disorder. The persisting negative and cognitive symptoms that are unresponsive to pharmacotherapy reveal the impairment of neuroprotective aspects of schizophrenia. In this review, of the several neuroprotective factors, we mainly focused on neuroinflammation, neurogenesis, and oxidative stress. We conducted a narrative and selective review. Neuroinflammation is mainly mediated by pro-inflammatory cytokines and microglia. Unlike peripheral inflammatory responses, neuroinflammation has a role in various neuronal activities such as neurotransmission neurogenesis. The cross-talk between neuroinflammation and neurogenesis usually has beneficial effects in the CNS under physiological conditions. However, uncontrolled and chronic neuroinflammation exert detrimental effects such as neuronal loss, inhibited neurogenesis, and excessive oxidative stress. Neurogenesis is also a major component of neuroprotection. Adult neurogenesis mainly occurs in the hippocampal region, which has an important role in memory formation and processing. Impaired neurogenesis and an ineffective response to antipsychotics may be thought to indicate a deteriorating course of schizophrenia. Oxidative stress and excessive dopaminergic neurotransmission may create a vicious cycle and consequently disturb NMDA receptor-mediated glutamatergic neurotransmission. Based on the current evidences, several neuroprotective therapeutic approaches have been reported to be efficacious for improving psychopathology, but further longitudinal and large-sample based studies are needed.

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“…Sixteen general symptom studies explored various aspects of medial temporal morphometry. Ten did not report any significant relationships between the presence or severity of TD and measures of medial temporal structure (Arango et al, 2003;Barta et al, 1990;Bersani et al, 2009;Guo et al, 2014;Kawasaki et al, 1997;Price et al, 2010;Sanfilipo et al, 2000;Szendi et al, 2006;Takahashi et al, 2006b;Yamasue et al, 2004). The pattern of findings amongst four of the remaining six studies indicated altered morphometry within the amygdala and hippocampus, particularly reductions in volume on the left side with greater positive or total TD (Bogerts et al, 1993;Fukuzako et al, 1996;Rajarethinam et al, 2001;Sallet et al, 2003b).…”

Section: Medial Temporal Lobe and Associated Subcortical Regionsmentioning

confidence: 97%