Influence of Obesity on Bone Turnover Markers and Fracture Risk in Postmenopausal Women

Gómez, Juan José López; Pérez-Castrillón, José-Luis; Santos, Isabel García de; Pérez-Alonso, María; Izaola-Jáuregui, Olatz; Primo-Martín, David; Luis, Daniel Antonio de

doi:10.3390/nu14081617

Cited by 17 publications

(14 citation statements)

References 22 publications

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“…Other research has revealed that even though rats appeared to show beneficial improvements in bone mineral density in response to the presence of excess body mass in an osteoporosis model, 15 Turcotte et al, 16 confirmed obesity does appear to induce apparent beneficial increases in the bone mineral density of overweight human subjects, along with an enhancement of their bone micro architecture and bone strength. On the other hand, Lopez-Gomez et al, 17 found postmenopausal women who were deemed obese tended to show lower levels of bone formation markers than those who were deemed to be of a healthy weight. In addition, other data indicate that bone quality in the obese case may not be sufficient to successfully avert a fragility fracture because other factors are involved.…”

Section: Resultsmentioning

confidence: 97%

Obesity and bone health: key 2020–2022 highlights and implications

Marks¹

2022

AOWMC

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Sound bone health is crucial for life affirming activities, but is bone physiology impacted in the face of excess body weight? Since fractures and osteoporosis are on the rise, is obesity a risk factor for, as well as a possible negative albeit remediable correlate of bone health in the older adult? To examine this premise the PUBMED and GOOGLE SCHOLAR data bases were sourced for relevant data published between January 1 2020 and November 1 2022 in an effort to capture post COVID-19 possible research observations on the topic. These data bases show while a pervasive idea has been that obesity may be beneficial in some respects to bone mineral density attributes and impart fracture protection, several current publications tend to portray a negative impact of obesity on bone health via multiple proposed mechanisms. However, the research points to a strong need for continued research as well as clinical vigilance of vulnerable individuals both young and old in a period where obesity rates in all age groups appear to be on the rise, along with cases of bone fragility and osteoarthritis that can both foster high morbidity and mortality rates and possibly more challenging weight issues in the face of painful fractures or joint derangement.

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Section: Resultsmentioning

confidence: 97%

Obesity and bone health: key 2020–2022 highlights and implications

Marks¹

2022

AOWMC

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“…T2DM is associated with poor trabecular microarchitecture and bone strength in obese men. The higher fracture risk can be attributed to the effect of obesity on bone turnover markers (6). In the present study, the patient was selected based on the absence of diabetes complications with normal parathyroid and renal functions.…”

Section: Discussionmentioning

confidence: 99%

“…Body weight and body mass index are thought to be strong predictors of osteoporotic fractures. There have been several studies on the relationship between body mass index and bone mineral density in women, but only a few on men so far (6). The preservation of the skeletal system is determined by calcium, which is one of the essential minerals involved in bone homeostasis and is linked to increased bone minerals (7)(8).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Total Procollagen Type 1 Intact N-terminal Propeptide, C-telopeptide of type 1 collagen, Bone Mineral Density and its Relationship to Body Mass Index in Men with Type 2 Diabetes

ABED¹,

Rasheed²,

G.Hussein³

2022

JFacMedBagdad

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Background: Type 2 diabetes negatively affects the biochemical parameters of bone turnover more than obesity and is associated with an increased risk of osteoporosis and fragility fractures. Obesity and type 2 diabetes (T2DM) are linked to increased fracturing risk; however, the effect of obesity on diabetes-related bone deficit is unknown. Objective: The goal of this research is to compare the indications, bone density, and bone turnover in T2DM men and a control group, and to investigate the effect of body mass index on bone turnover levels. Subjects, Material and Method: This case-control study was conducted on 120 men whose ages were from 40 - 69 years. They were grouped into two categories: T2DM (n=80) and healthy control (n=40). Serum samples from both groups were analyzed for blood glucose, Calcium and Albumin, by using (Cobas c111), PTH by (Cobas e 411), P1NP and CTX-1 levels in the serum using ELISA kits. Participants underwent (DEXA) measuring Bone Mass Density (BMD) at the lumbar spine. Results: The control (obese and non-obese) participants had statistically significant higher levels of CTX-1 and P1NP than the patients (obese and non-obese) (P-value = 0.000). There was no significant differences in Spine BMD, T-score (p-value = 0.27 and 0.37 respectively). Conclusion: Men with T2DM had a low bone turnover level and deteriorated bone quality compared to controls. The obese healthy controls can maintain healthy bone metabolism if T2DM is prevented.

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“…On the one hand, it has been reported that a high weight and body mass index (BMI) are protective factors against the risk of fracture [ 32 , 33 ]. However, clinical and epidemiological studies have shown that obesity may be a risk factor for fragility fractures [ 34 , 35 ]. Our results showed that obese rats exposed to hypoxia had a more deteriorated bone structure than normoweight rats who were subject to hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Bone Histomorphometry in Rat and Guinea Pig Animal Models Subject to Hypoxia

Fernandez-Bueno

Real

Sainz-Aja

et al. 2022

IJMS

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Hypoxia may be associated with alterations in bone remodeling, but the published results are contradictory. The aim of this study was to characterize the bone morphometry changes subject to hypoxia for a better understanding of the bone response to hypoxia and its possible clinical consequences on the bone metabolism. This study analyzed the bone morphometry parameters by micro-computed tomography (μCT) in rat and guinea pig normobaric hypoxia models. Adult male and female Wistar rats were exposed to chronic hypoxia for 7 and 15 days. Additionally, adult male guinea pigs were exposed to chronic hypoxia for 15 days. The results showed that rats exposed to chronic constant and intermittent hypoxic conditions had a worse trabecular and cortical bone health than control rats (under a normoxic condition). Rats under chronic constant hypoxia were associated with a more deteriorated cortical tibia thickness, trabecular femur and tibia bone volume over the total volume (BV/TV), tibia trabecular number (Tb.N), and trabecular femur and tibia bone mineral density (BMD). In the case of chronic intermittent hypoxia, rats subjected to intermittent hypoxia had a lower cortical femur tissue mineral density (TMD), lower trabecular tibia BV/TV, and lower trabecular thickness (Tb.Th) of the tibia and lower tibia Tb.N. The results also showed that obese rats under a hypoxic condition had worse values for the femur and tibia BV/TV, tibia trabecular separation (Tb.Sp), femur and tibia Tb.N, and BMD for the femur and tibia than normoweight rats under a hypoxic condition. In conclusion, hypoxia and obesity may modify bone remodeling, and thus bone microarchitecture, and they might lead to reductions in the bone strength and therefore increase the risk of fragility fracture.

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Influence of Obesity on Bone Turnover Markers and Fracture Risk in Postmenopausal Women

Cited by 17 publications

References 22 publications

Obesity and bone health: key 2020–2022 highlights and implications

Obesity and bone health: key 2020–2022 highlights and implications

Assessment of Total Procollagen Type 1 Intact N-terminal Propeptide, C-telopeptide of type 1 collagen, Bone Mineral Density and its Relationship to Body Mass Index in Men with Type 2 Diabetes

Analysis of Bone Histomorphometry in Rat and Guinea Pig Animal Models Subject to Hypoxia

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