Influence of obesity on bone density in postmenopausal women

Silva, Henyse G. Valente da; Mendonça, Laura Maria Carvalho de; Conceição, Flávia Lúcia; Zahar, Silvia Eliane Vasconcelos; Farias, Maria Lúcia Fleiuss

doi:10.1590/s0004-27302007000600008

Cited by 58 publications

(45 citation statements)

References 42 publications

(45 reference statements)

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“…These findings correspond with the results of the current study. Almost all studies reported a negative relationship between age and BMD, which confirms the findings of the current study (25)(26)(27).…”

Section: Discussionsupporting

confidence: 91%

Relationship between Bone Mineral Density and Physical Activity Level in the Elderly

Amiri¹,

Hosseini²,

Farhad³

et al. 2015

Ann. Appl. Sport Sci

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This study purposed to investigate the relationship between physical activity level and bone mineral density (BMD) in the elderly of Amirkola in northern Iran. This cross-sectional study was part of a proposal to assess the situation of the elderly in Amirkola (AHAP) (Amirkola Health and Ageing Project) conducted on 1113 elderly individuals (616 males and 497 females) in Amirkola city. Physical activity was measured using a standard questionnaire of physical activity in the elderly (Physical Activity Scale for Elderly). Mineral bone mass was measured using dual energy X-ray absorptiometry in the femur neck and lumbar spines, and vitamin D levels were measured in morning blood samples. T-test, ANOVA, Pearson correlation, and linear regression tests were used to analyze data. The mean physical activity of women (118.6±55.5) was higher than that of men (110.3±71.1) (p=0.035). This study found a significant positive relationship between total physical activity and femur bone mineral density (p=0.001 and r=0.101), but this association was not significant in lumbar spines (p=0.597 and r=0.016), though bone mineral density increased in both areas with increased physical activity (p=0.098). A significant inverse relationship between age and physical activity (p=0.001) and between age and bone mineral density (p=0.001) was observed. Analyzing the influencing variables using the linear regression model indicated physical activity, age, and BMI had significant relationships with bone mineral density in the femur, but neither vitamin D nor calcium played a role. Given the positive correlation between bone mineral density and physical activity, it can be concluded that low intensity weight-bearing activities carried out in compliance with safety rules may be suitable for the elderly.

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Section: Discussionsupporting

confidence: 91%

Relationship between Bone Mineral Density and Physical Activity Level in the Elderly

Amiri¹,

Hosseini²,

Farhad³

et al. 2015

Ann. Appl. Sport Sci

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“…It is important to emphasize that changes in the amount and distribution of body fat are likely to affect both accuracy and precision of BMD (32). However, it is not known how much of this error would affect the interpretation of the DXA results.…”

Section: Fracture Risk Assessmentmentioning

confidence: 99%

Obesity and fractures

Premaor

Comim

Compston³

2014

Arq Bras Endocrinol Metab

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Until recently obesity was believed to be protective against fractures. However, a report from a Fracture Liaison Clinic in the UK (2010) reported a surprisingly high proportion of obese postmenopausal women attending the clinic with fractures, and in the GLOW study (2011), a similar prevalence and incidence of fractures in obese and non-obese postmenopausal women was observed. Subsequently, other studies have demonstrated the importance of obesity in the epidemiology of fractures. Obese women are at increased risk of fracture in ankle, leg, humerus, and vertebral column and at lower risk of wrist, hip and pelvis fracture when compared to non-obese women. In men, it has been reported that multiple rib fractures are associated with obesity. Furthermore, falls appear to play an important role in the pathogenesis of fractures in obese subjects. Regarding hip fracture and major fractures, the FRAX algorithm has proven to be a useful predictor in obese individuals. Obese people are less likely to receive bone protective treatment; they have a longer hospital stay and a lower quality of life both before and after fracture. Moreover, the efficacy of antiresorptive therapies is not well established in obese people. The latter is a field for future research. Arq Bras Endocrinol Metab. 2014;58(5):470-7 Keywords Obesity; fractures; osteoporosis; osteopenia ReSumo Acreditava-se que pessoas obesas estavam protegidas contra fraturas. No entanto, um estudo realizado no Reino Unido (2010) encontrou uma proporção surpreendentemente alta de obesidade entre as mulheres na pós-menopausa que se consultaram em uma Clínica de Fraturas Ósseas. Da mesma maneira, o estudo GLOW (2011) observou prevalência e incidência semelhantes de fraturas em mulheres na pós-menopausa obesas e não obesas. Posteriormente, vários outros estudos têm demonstrado a importância da obesidade na epidemiologia de fraturas. Mulheres obesas têm maior risco de fratura no tornozelo, na perna, no úmero e na coluna vertebral e têm menor risco de fratura de punho, quadril e pelve quando comparadas às mulheres não obesas. A associação entre fraturas múltiplas de costelas e obesidade foi descrita em homens. Além disso, as quedas parecem desempenhar um papel importante na patogênese de fraturas em pacientes obesos. O algoritmo FRAX parece ser uma ferramenta útil na predição do risco de fraturas em indivíduos obesos. Indivíduos obesos são menos propensos a receber tratamento preventivo para as fraturas ósseas e, quando sofrem uma fratura óssea, sua internação costuma ser mais longa do que a internação de indivíduos magros. A qualidade de vida dos indivíduos obesos é menor antes e depois da fratura. Não obstante, a eficácia de terapias antirreabsorção não está bem estabelecida em pessoas obesas. Este último é um campo para pesquisas futuras. Arq Bras Endocrinol Metab. 2014;58(5):470-7 Descritores Obesidade; fraturas ósseas; osteoporose, osteopenia

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“…Abdominal obesity and a low HDL cholesterol level are considered to be the main factors increasing metabolic syndrome prevalence in postmenopausal women (5,6). Obesity is very widespread among postmenopausal women, and studies have shown that approximately 50% of postmenopausal women are obese (7). A remodeling of body fat distribution is seen in women with the occurrence of progressive and permanent estrogen deficiency, while gluteofemoral fat accumulation decreases and metabolically active fat accumulation increases (8).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Metabolic Syndrome and Effect of Hormone Profile in Postmenopausal Patients

Şahin¹,

Salman²,

Ayanoğlu³

et al. 2016

JAREM

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Objective: The purpose of this study was to evaluate the prevalence and connection with hormonal changes of metabolic syndrome and its components in postmenopausal women based on a literature survey. Methods:The medical records of 138 postmenopausal patients were retrospectively reviewed between January 2013 and March 2014. Patients with surgical menopause and those who underwent hormone replacement therapy, chemotherapy, and radiotherapy were excluded. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Patients' demographic data, menopausal status, medical history, and physical examination and clinical laboratory data were analyzed. Data were evaluated statistically.Results: In total, 128 patients were included in this study. The menopausal age of patients in the metabolic syndrome group was 50.06±2.93 and that in the non-metabolic syndrome group was 45.16±4.4 years. The prevalence of metabolic syndrome was observed in 43.4% patients in this study. A statistically significant negative high correlation (p<0.05) was observed between waist circumference and the number of metabolic components with FSH-LH levels. Conclusion:The prevalence of metabolic syndrome among postmenopausal women is high, and abdominal obesity and low HDL levels are strong predictors. These components can lead to an increase in cardiovascular diseases. Thus, it is encouraging to adopt lifestyle changes that reduce the prevalence of metabolic syndrome. (JAREM 2016; 6: 35-9)

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Influence of obesity on bone density in postmenopausal women

Cited by 58 publications

References 42 publications

Relationship between Bone Mineral Density and Physical Activity Level in the Elderly

Relationship between Bone Mineral Density and Physical Activity Level in the Elderly

Obesity and fractures

Prevalence of Metabolic Syndrome and Effect of Hormone Profile in Postmenopausal Patients

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