Influence of non‐volatile anesthetics on the migration behavior of the human breast cancer cell line 
MDA‐MB‐468

Abstract

These results show that different anesthetic drugs are able to modulate the migratory machinery of human breast carcinoma cells in vitro.

GABA(A) Receptor Pi (GABRP) Stimulates Basal-like Breast Cancer Cell Migration through Activation of Extracellular-regulated Kinase 1/2 (ERK1/2)

“…Our observation that GABRP functions in BLBC migration is supported by previous reports indicating GABA(A) receptor signaling is pro-migratory in cancer cell lines (17)(18)(19). Interestingly, the studies evaluating propofol-induced migration in breast cancer used the MDA-MB-468 cell line.…”

“…Most importantly, breast cancer patient brain metastases exhibit a GABAergic phenotype including the up-regulation of GABA(A) receptors, GABA transporters and GAD expression (16). A putative role for GABA(A) in breast cancer is further supported by the observation that propofol, a multifunctional drug with agonist activity for the GABA(A) receptor, induces actin reorganization and migration of breast cancer cells through collagen matrices (17,18). GABA treatment correspondingly increases cell number, matrix metalloprotease (MMP) expression and in vitro invasiveness in prostate cancer cells (19,20).…”

“…46), thus, future studies should delineate how differential GABA(A) isoform expression correlates with ligand dependence and resulting tumorigenicity. These studies will be critical to explain why GABA is pro-migratory in certain cancer cells (17,18), but may be anti-migratory in others (23).…”

“…Treating breast cancer cell lines with GABA(A) agonists induces migration (17,18) and although these studies did not evaluate specifically whether altered ionic flux was responsible for changes in cell migration, calcium signaling alone induces breast cancer cell line motility (38). To test whether the GABRP-mediated BLBC migration described herein is due to changes in intracellular calcium signaling, we treated parental HCC1187 cells with 100 M GABA and evaluated changes in intracellular calcium levels by FURA2.…”

Effects of Propofol on Several Membrane Characteristics of Cervical Cancer Cell Lines

“…Retrospective clinical data and results generated using animal models suggest that the administration of certain anesthetic drugs and techniques after surgery for cancer attenuate immunosuppression and minimize metastasis [9][10][11][12][13][14][15][16][17].…”