Influence of nitrous oxide upon regional brain levels of methionine-enkephalin-like immunoreactivity in rats

Quock, Raymond M.; Kouchich, F. J.; Tseng, Leon F.

doi:10.1016/0361-9230(86)90052-3

Cited by 33 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared to room air-exposed rats, animals exposed to 75% N2O in O2for 60 min had significant (12-18%) increases in the concentrations of ME-like immunoreactivity in the brainstem, spinal cord, hypothalamus and corpus striatum but not in the cerebral cortex or diencephalon (Quock et al, 1986), although a similar study showed no effect of N2O on ME levels (Morris and Livingston, 1984). In rats exposed to N2O in O2for 60 min, there was a concentration-related increase in levels of β-endorphin in the medial basal hypothalamus and the periaqueductal gray, which are sites along the neuroaxis functionally involved with analgesia (Zuniga et al, 1987a).…”

Section: Effects Of General Anesthetics On Concentrations Of Endogenomentioning

confidence: 84%

The role of dialect density in nonword repetition performance: An examination with at-risk African American preschool children

Moyle¹,

Heilmann²,

Finneran³

2014

Clinical Linguistics & Phonetics

View full text Add to dashboard Cite

The Nonword Repetition Task (NRT) is considered to be a less-biased language measure for children from cultural minority groups. In the current study, we examined NRT performance of 50 at-risk, preschool-age children who spoke African American English (AAE). In addition to the NRT, measures included AAE dialect density and several standardised language tests. The primary aim was to determine significant contributors to NRT performance. We hypothesised that the language measures would significantly contribute to NRT performance while dialect density would be an insignificant contributor. Contrary to our predictions, dialect density was a unique and significant predictor of NRT performance (in addition to phonological awareness), while the language measures were not significant predictors. The current findings cast doubt on categorising the NRT as a less-biased language assessment for AAE-speaking preschoolers; however, the NRT may have potential as a screener for identifying preschoolers at risk for delays in literacy acquisition.

show abstract

Section: Effects Of General Anesthetics On Concentrations Of Endogenomentioning

confidence: 84%

The role of dialect density in nonword repetition performance: An examination with at-risk African American preschool children

Moyle¹,

Heilmann²,

Finneran³

2014

Clinical Linguistics & Phonetics

View full text Add to dashboard Cite

show abstract

“…Recent studies demonstrating region‐dependent effects of N 2 O on dopamine and/or norepinephrine concentrations or turnover in the brain [7, 8] have provided further direct evidence for the involvement of dopamine and/or norepinephrine in transducing some of N 2 O's effects in the central nervous system. Although the underlying mechanisms are unclear, several studies have suggested that N 2 O releases opioid peptides in the central nervous system [9, 10]. In addition, there is much evidence suggesting that N 2 O produces similar physiological effects as opioids [11].…”

mentioning

confidence: 99%

Recent advances in understanding the actions and toxicity of nitrous oxide

Maze

Fujinaga

2000

Anaesthesia

View full text Add to dashboard Cite

“…Compared to room air-exposed rats, animals exposed to 75% N 2 O in O 2 for 60 min had significant (12-18%) increases in the concentrations of ME-like immunoreactivity in the brainstem, spinal cord, hypothalamus and corpus striatum but not in the cerebral cortex or diencephalon (Quock et al, 1986), although a similar study showed no effect of N 2 O on ME levels (Morris and Livingston, 1984). In rats exposed to N 2 O in O 2 for 60 min, there was a concentration-related increase in levels of h-endorphin in the medial basal hypothalamus and the periaqueductal gray, which are sites along the neuroaxis functionally involved with analgesia (Zuniga et al, 1987a).…”

Section: Effects Of General Anesthetics On Plasma Levels Of Endogenoumentioning

confidence: 96%

Do inhalation general anesthetic drugs induce the neuronal release of endogenous opioid peptides?

Quock

Vaughn

2005

Life Sciences

Self Cite

View full text Add to dashboard Cite

The antagonism of some effects of inhalation general anesthetic agents by naloxone suggests that there may be an opioid component to anesthetic action. There is evidence that this opioid action component is due to neuronal release of endogenous opioid peptides. The strongest evidence is provided by studies that monitor changes in the concentration of opioid peptides in the perfused brain following inhalation of the anesthetic. Indirect or circumstantial evidence also comes from studies of anesthetic effects on regional brain levels of opioid peptides, antagonism of selected anesthetic effects by antisera to opioid peptides and anesthetic-induced changes radioligand binding to opioid receptors. It is likely that some inhalation general anesthetics (e.g., nitrous oxide) can induce neuronal release of opioid peptides and that this may contribute to certain components of general anesthesia (e.g., analgesia). More definitive studies utilizing in vivo microdialysis or autoradiography in selected areas of the brain during induction and successive states of general anesthesia have yet to be conducted.

show abstract

Influence of nitrous oxide upon regional brain levels of methionine-enkephalin-like immunoreactivity in rats

Cited by 33 publications

References 15 publications

The role of dialect density in nonword repetition performance: An examination with at-risk African American preschool children

The role of dialect density in nonword repetition performance: An examination with at-risk African American preschool children

Recent advances in understanding the actions and toxicity of nitrous oxide

Do inhalation general anesthetic drugs induce the neuronal release of endogenous opioid peptides?

Contact Info

Product

Resources

About