Influence of nitrate and nitrite on electrolyte transport by the rat small and large intestine

Würmli, Regula; Wolffram, Siegfried; Scharrer, E.

doi:10.1016/0300-9629(87)90110-1

Comparative Biochemistry and Physiology Part A: Physiology

1987

DOI: 10.1016/0300-9629(87)90110-1

|View full text |Cite

Influence of nitrate and nitrite on electrolyte transport by the rat small and large intestine

Regula Würmli

Siegfried Wolffram

E. Scharrer

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1991

2006

Publication Types

Select...

Article6

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 10 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major effects of acute nitrite intoxication include relaxation of vascular smooth muscle, vasodilatation, decrease of blood pressure, and methemoglobinemia, which results in anoxia (De SaintBlanquat 1980;Bruning-Fann and Kaneene 1993a;Gangolli et al 1994). Nitrite also influences carbohydrate and nitrogen metabolism, causing disturbances in such processes as glycogenolysis, glycolysis, gluconeogenesis, ammonia utilization, and ureagenesis (Wiechetek et al 1993;Karlik et al 1995) and alteration of the process of intestinal absorption (Grudzi½ski and Szyma½ski 1991;Würmli et al 1987). Furthermore, nitrite can react in vitro and in vivo with amines or amides to form potent carcinogenic N-nitroso compounds (Bruning-Fann and Kaneene 1993b).…”

mentioning

confidence: 98%

Sodium nitrite, a potent relaxant of rat stomach fundus: in vitro evidence

Ceregrzyn¹,

Ozaki²,

Kuwahara³

et al. 1998

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

The effects of sodium nitrite (0.1, 1, 10 mM) on mechanical activity of isolated rat stomach fundus muscle and the influence of guanylate cyclase activity inhibitor (methylene blue) and channel inhibitors (tetrodotoxin, charybdotoxin, apamin) were studied. Nitrite evoked dose-dependent relaxation in the longitudinal and circular muscle layers. The lowest effective concentration of sodium nitrite was 0.1 mM, which is comparable with the NOAEL (no observed adverse effect level). Tetrodotoxin (1 microM) markedly inhibited electrically induced contraction and rebound relaxation, but did not influence the nitrite-induced relaxation. Charybdotoxin (100 nM) decreased the relaxation evoked by 10 mM nitrite to 52.3 and 65.7% of control reaction in the circular and longitudinal muscle layer, respectively. Apamin (100 nM) did not influence the nitrite-induced relaxation. Methylene blue (10 microM) decreased relaxation induced by nitrite in the longitudinal and circular muscle layer, respectively, to 66.7 and 54.3% of the response to 1 mM nitrite alone. Relaxation induced by nitrite was decreased in the presence of L-cysteine (5 mM), and in the circular and longitudinal muscle layer reached 29.6 and 23.1%, respectively, of the response to 1 mM nitrite alone. We conclude that the relaxing effect of nitrite on gastric fundus results from its direct action on smooth muscle cells and probably the enteric nervous system is not involved in this action. The nitrite-elicited relaxation depends on activation of guanylate cyclase and high conductance Ca2+-activated potassium channels; however, activation of potassium channels might be a part of or might act in parallel with the mechanism involving the cyclic GMP system. Effects of nitrite observed in the presence of L-cysteine suggest that nitrosothiols are not responsible for nitrite-evoked activation of guanylate cyclase.

show abstract

mentioning

confidence: 98%

Sodium nitrite, a potent relaxant of rat stomach fundus: in vitro evidence

Ceregrzyn¹,

Ozaki²,

Kuwahara³

et al. 1998

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

show abstract

The effect of subchronic poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats

Grudziński

Szymański

1991

Arch. Environ. Contam. Toxicol.

View full text Add to dashboard Cite

The intestinal transport of D-xylose was studied during subchronic poisoning of male Wistar rats with the oral administration of potassium nitrate and sodium nitrite. The metabolic parameters of small intestine mucosa were determined one hour after xylose administration, i.e., Na+/K(+)-ATPase, alkaline phosphatase, oxygen consumption, and lactic acid level. Nitrite reduced the absorption of xylose and decreased the activity of Na+/K(+)-ATPase and alkaline phosphatase. No effect of sodium nitrite was demonstrated on the aerobic metabolism of intestinal mucosa with an increased lactic acid level. Potassium nitrate did not effect the processes of intestinal absorption of xylose nor the metabolic parameters of small intestine mucosa.

show abstract

The effect of acute poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats

Grudziński

Szymański

1991

Arch. Environ. Contam. Toxicol.

View full text Add to dashboard Cite

The intestinal transport of D-xylose was studied during the acute poisoning of male Wistar rats with orally administered potassium nitrate and sodium nitrite. At the peak of xylose absorption, the metabolic parameters of Na+/K(+)-ATPase, alkaline phosphatase, oxygen uptake, and lactic acid level were determined in the small intestine mucosa. Nitrite in a dose of 80 mg NaNO2/kg b.w. increased the permeability of gastric mucosa for D-xylose and raised the uptake of oxygen by the small intestine mucosa. No changes were observed in the activity of Na+/K(+)-ATPase and alkaline phosphatase. A dose of 10 mg NaNO2/kg b.w. was not followed by increased absorption of this sugar. It was also demonstrated that potassium nitrate had no effect on the process of intestinal absorption of D-xylose and failed to change the determined metabolic parameters of the small intestine mucosa.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Influence of nitrate and nitrite on electrolyte transport by the rat small and large intestine

Cited by 10 publications

References 10 publications

Sodium nitrite, a potent relaxant of rat stomach fundus: in vitro evidence

Sodium nitrite, a potent relaxant of rat stomach fundus: in vitro evidence

The effect of subchronic poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats

The effect of acute poisoning with potassium nitrate and sodium nitrite on the processes of intestinal absorption of D-xylose in rats

Contact Info

Product

Resources

About