Influence of Nicardipine on the Blood Pressure at Rest and on the Pressor Responses to Cold, Isometric Exertion, and Dynamic Exercise in Hypertensive Patients

Sh, Taylor; Silke, Bernard; Rc, Ahuja; Okoli, R

doi:10.1097/00005344-198209000-00016

Cited by 50 publications

(21 citation statements)

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“…The hypertensive group showed an increase in heart rate, an effect shown previously and found to be dose-dependent (Taylor et al, 1982). Although the decrease in blood pressure was similar in both groups there was no change in the heart rate of the normotensives.…”

Section: Hsupporting

confidence: 70%

Antihypertensive and renal effects of nicardipine.

Schaik¹,

Nistelrooy²,

Geyskes³

1984

Brit J Clinical Pharma

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Both the acute blood pressure lowering and renal effects of the calcium antagonist nicardipine and those after 1 week's treatment were investigated in 10 normotensive volunteers and in 10 patients with mild to moderate essential hypertension. 2 After 1 week of placebo, nicardipine was administered orally for 1 week (20 mg three times daily), Investigations, done on the first and last day of nicardipine treatment were compared with those on the last day of placebo. 3 During water loading, nicardipine increased urinary volume and urinary excretion of sodium significantly after 1 week nicardipine treatment. 4 In the normotensive group the natriuretic effect was caused by a decrease of fractional proximal and distal reabsorption of sodium. In the hypertensive group the natriuresis was achieved mainly by an increase of the rate of glomerular filtration (GFR) and also by a slight distal effect. 5 Our results show that nicardipine had natriuretic effects. There were trends suggesting that the renal effects may differ between patients with essential hypertension and normotensive volunteers, but the findings might also be related to differences in age between the groups.

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Section: Hsupporting

confidence: 70%

Antihypertensive and renal effects of nicardipine.

Schaik¹,

Nistelrooy²,

Geyskes³

1984

Brit J Clinical Pharma

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“…Previous studies have shown a significant decrease in systemic blood pressure in hypertensive patients after nicardipine therapy (Jones et al, 1983;Taylor et al, 1982). In our study, the blood pressure fall was transient * * in all patients except for the two hypertensive ones.…”

Section: Figsupporting

confidence: 58%

Acute and chronic effects of nicardipine on systolic and diastolic left ventricular performance in patients with heart failure: A pilot study

Lahiri

Robinson

Kohli

et al. 1986

Clinical Cardiology

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Summary:Nicardipine is a new calcium ion antagonist with vasodilating properties which has been shown to be effective in the treatment of hypertension and angina. We have studied its effect on systolic and diastolic left ventricular function in patients with mild to moderate degrees of congestive heart failure. Ten male patients with New York Heart Association Class I1 and I11 heart failure underwent acute treatment with an intravenous infusion of nicardipine (10 mg over 10 minutes). A nuclear probe was used to monitor left ventricular ejection fraction, peak filling rate, and relative cardiac output. Blood pressure and heart rate were also measured. The blood pressure (meanfSD) fell from 133f26/86f11 mmHg to 103 f22/69 k 13; the heart rate rose from 67 f 9 beatslmin to 85 f 10; left ventricular ejection fraction from 31 f 7 to 38f6%; relative cardiac output from 24f9 to 41f11; peak filling rate from 1.18f0.4 end-diastolic volume per second to 1.82f0.4 ( p~0 . 0 0 1 in all cases) at the end of infusion. After 4 weeks of chronic treatment in eight patients (20 mg to be taken three times daily (tds) in one and 40 mg tds in 7), the blood pressure and heart rate had returned to baseline values but the improvements in left ventricular ejection fraction, relative cardiac output, and peak filling rate were sustained; this was associated with functional improvement in all 8 patients. This preliminary study suggests that nicardipine has a potent vasodilator effect and produces significant objective improvement in left ventricular function, without producing any negative ionotropic effects. Further studies are required to confirm these effects in a wider range of patients with heart failure.

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“…et al., 1982). This is achieved predominantly by dilatation of the systemic arteriolar resistance vessels (Fleckenstein, 1977;Mikkelsen et al, Methods 1979) without substantially disturbing the circulaPatients tory responses to everyday pressor stimuli (Taylor et al, 1982). The identification of the Fifty-four white patients (nine male; 45 female) dose-range of the drug likely to achieve an aged 32-69 years, with asymptomatic, uncompli- Between-group comparisons were performed by analysis of variance followed by paired two-tailed t tests (Snedecor & Cochran, 1980).…”

Section: Introductionmentioning

confidence: 99%

Anti‐hypertensive dose‐response effects of nicardipine in stable essential hypertension.

Taylor¹,

Frais²,

Lee³

et al. 1985

Brit J Clinical Pharma

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1 The dose-response effects of oral nicardipine on the systemic blood pressure were examined in 54 patients with uncomplicated essential hypertension (DBP > 100 mm Hg). 2 The study was designed in four sequential stages. A 2 week single-blind placebo run-in period was followed by dose titration with nicardipine at 2 week intervals. Patients achieving the target DBP < 95 mm Hg were then crossed over to placebo for 2 weeks, following which the previous dose of nicardipine was readministered for 6 weeks. 3 Forty-eight patients completed the dose-titration phase. The target DBP 95 mm Hg was achieved in 33; in eight after 10 mg three times daily, in 21 after 20 mg three times daily, in three after 30 mg three times daily and in one after 40 mg three times daily. In the 48 patients, systolic blood pressure was reduced from 188 + 25 to 158 + 21 mm Hg (P < 0.001) and diastolic blood pressure from 111 + 9 to 93 + 13 mm Hg (P < 0.001); heart rate increased from 81 + 7 to 87+ 13 beats min-' (P < 0.01). 4 Thirty-one of the 33 patients completed the crossover to placebo, which was accompanied by a significant increase towards pretreatment blood pressure levels. Reinstitution of nicardipine at the previous dose resulted in a reduction of SBP and DBP to levels not significantly different from those at the end of the dose-titration stage. 5 No significant effects of nicardipine were found radiographically on heart size or pulmonary vasculature, resting electrocardiogram, plasma biochemistry or haematological variables. 6 These results confirm the anti-hypertensive effectiveness of oral nicardipine and establish the dose-range over which it can be expected to lower blood pressure in a substantial number of patients with mild and moderate uncomplicated essential hypertension.

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Influence of Nicardipine on the Blood Pressure at Rest and on the Pressor Responses to Cold, Isometric Exertion, and Dynamic Exercise in Hypertensive Patients

Cited by 50 publications

References 0 publications

Antihypertensive and renal effects of nicardipine.

Antihypertensive and renal effects of nicardipine.

Acute and chronic effects of nicardipine on systolic and diastolic left ventricular performance in patients with heart failure: A pilot study

Anti‐hypertensive dose‐response effects of nicardipine in stable essential hypertension.

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