Influence of New Modified Biliopancreatic Diversion on Blood Glucose and Lipids in GK rats

Weng, Shangeng; Zhang, Bin; Changguo, Xu; Su, Feng; He, Hongxing

doi:10.1007/s11695-016-2320-z

Cited by 2 publications

(1 citation statement)

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“…3 ) alone produced no hypoglycemic effect. Also, the levels of blood bile acid changed after biliopancreatic diversion 2 – 4 . Therefore, we speculated that diversion of bile and pancreatic juices might affect the digestion and absorption of lipids and also the intestinal hepatic circulation of bile acids, which in turn, would reduce lipid toxicity and blood glucose levels.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats

Wang

Zhang

Weng

2021

Sci Rep

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To investigate the effect of duodenal-jejunal bypass (DJB) surgery on postoperative blood glucose in type 2 diabetic rats, and further explore possible mechanisms for the effect of surgical treatment of type 2 diabetes. Forty rats with type 2 diabetes were randomly assigned to 4 groups (n = 10 rats per group), which subsequently underwent DJB, new biliopancreatic diversion (NBPD) or duodenal-jejunal exclusion (DJE) surgery or a sham operation (SHAM). Fasting glucose, 2-h postprandial glucose and blood lipids were measured, and the mRNA in liver and intestinal tissue for bile acid receptor (FXR), as well as the FXR protein expression in the liver tissues were determined. Postprandial blood glucose and fasting TG and FFA in the DJB and NBPD groups were significantly lower than those in the SHAM group and preoperative (p < 0.05) at 8 weeks postoperation. Liver FXR protein was expressed at significantly higher in the DJB and NBPD groups than in the other two (p < 0.05), and the intestinal FXR mRNA in the DJE group were highest. DJB up-regulates the expression of bile acid receptors in the liver and down-regulates those receptors in the intestinal tract via biliopancreatic diversion. This process reduces TG levels, and subsequently any lipotoxicity to islet cells to produce a hypoglycemic effect.

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Section: Introductionmentioning

confidence: 99%