SmFeAsO 1−x F x was irradiated in a fission reactor by a fast (E > 0.1 MeV) neutron fluence of 4 × 10 21 m −2 . The introduced defects increased the normal state resistivity due to a reduction in the mean free path of the charge carriers. This leads to an enhancement of the upper critical field at low temperatures. The critical current density within the grains, J c , increases upon irradiation. The second maximum in the field dependence of J c disappears and the critical current density becomes a monotonically decreasing function of the applied magnetic field.