2022
DOI: 10.1063/5.0072274
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Influence of network defects on the conformational structure of nanogel particles: From “closed compact” to “open fractal” nanogel particles

Abstract: We propose an approach to generate a wide range of randomly branched polymeric structures to gain general insights into how polymer topology encodes a configurational structure in solution. Nanogel particles can take forms ranging from relatively symmetric sponge-like compact structures to relatively anisotropic open fractal structures observed in some nanogel clusters and in some self-associating polymers in solutions, such as aggrecan solutions under physiologically relevant conditions. We hypothesize that t… Show more

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Cited by 15 publications
(22 citation statements)
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“…This same situation arises in linear polymer chains, but where the good solvent and θ -solvent scaling exponents are different from branched polymers. Future work will describe the size of compact 20 and open 21 nanogel particles that are more suitable when considering an extensive range of polymer molecular mass. We next briefly show that a simple extension of the renormalization (RG) group theory to describe the swelling of our nanogel particles appears to be promising for describing this type of crossover above the θ -point.…”
Section: Resultsmentioning
confidence: 99%
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“…This same situation arises in linear polymer chains, but where the good solvent and θ -solvent scaling exponents are different from branched polymers. Future work will describe the size of compact 20 and open 21 nanogel particles that are more suitable when considering an extensive range of polymer molecular mass. We next briefly show that a simple extension of the renormalization (RG) group theory to describe the swelling of our nanogel particles appears to be promising for describing this type of crossover above the θ -point.…”
Section: Resultsmentioning
confidence: 99%
“…The mass scaling of the ‘open gels’ was found to conform rather well with randomly branched polymers (‘lattice animals’), but the situation was found to be more complicated for the perfect nanogel particles whose size did not seem to conform with the expectations of randomly branched polymers. 21 In particular, the apparent mass scaling exponents describing the average size of these nanogel particles depended on the mesh spacing in the network. The radius of gyration mass scaling exponent when the mesh size was small was found to be consistent with that for the swollen linear chains composing the network in isolation ( ν ≈ 0.588) with increasing M while the apparent exponent was found to be near ( ν ≈ 1/3) with increasing branched points in each direction.…”
Section: Introductionmentioning
confidence: 99%
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“…Since we became aware of a different method used in the literature to estimate the hydrodynamic radius of macromolecules, also recently applied to nanogels, 56 that is based on the ZENO algorithm, 57 we also use this approach to evaluate R H for all investigated microgels. It is important to note that we find an overall consistency between the two methods, so that both appear to be valid approaches to estimate R H from implicit solvent simulations.…”
Section: Main Calculated Observablesmentioning
confidence: 99%