Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in Diabetic Feet

Jung, Jae A; Yoo, Ki Hyun; Han, Seung Kyu; Lee, Ye Na; Jeong, Seong-Ho; Dhong, Eun Sang; Kim, Woo-Kyung

doi:10.1097/01.asw.0000483038.18331.a4

Cited by 20 publications

(11 citation statements)

References 21 publications

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“…Despite the high hydrophobic properties of the group containing DDAC 8 wt % after putting the drop of water on the dressing surface, the water drop absorbed to it suddenly. The underlying principle of this phenomenon is due to the capillary suction pressure (Jung et al, 2016).

P_{normalc =} \frac{2 γ \cos θ}{Re}

…”

Section: Discussionmentioning

confidence: 99%

Physical and biological properties of blend‐electrospun polycaprolactone/chitosan‐based wound dressings loaded with N‐decyl‐N, N‐dimethyl‐1‐decanaminium chloride: An in vitro and in vivo study

et al. 2020

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Dual-pump electrospinning of antibacterial N-decyl-N, N-dimethyl-1-decanaminiumchloride (DDAC)-loaded polycaprolactone (PCL) nanofibers, and chitosan (CS)/polyethylene-oxide (PEO)-based wound dressings with hydrophilic and hydrophobic properties to eliminate and absorb pathogenic bacteria from wound surface besides antibacterial action and to support wound healing and accelerate its process. Physicochemical properties of the prepared nanofibrous mat as well as antibacterial, cytotoxicity, and cell compatibility were studied. The full-thickness excisional wound healing properties up to 3 weeks using hematoxylin and eosin and Masson-trichrome staining were investigated. Addition of DDAC to CS/PEO-PCL mats decreased the diameter of the nanofibers, which is a crucial property for wound healing as large surface area per volume ratio of nanofibers, in addition to proper cell adhesion, increases loading of DDAC in mats and leads to increased cell viability and eliminating Gram-positive bacteria at in vitro studies. In vivo studies showed DDAC-loaded CS/PEO-PCL mats increased epithelialization and angiogenesis and decreased the inflammation according to histological results. We demonstrated that hydrophobic PCL/DDAC mats, besides antibacterial properties of DDAC, absorbed and eliminated the hydrophobic pathological microorganisms, whereas the hydrophilic nanofibers consisted of CS/PEO, increased the cell adhesion and proliferation due to positive charge of CS. Finally, we were able to increase the wound healing quality by using multifunctional wound dressing. CS/PEO-PCL containing 8 wt % of DDAC nanofibrous mats is promising as a wound dressing for wound management due to the favorable interactions between the pathogenic bacteria and PCL/CS-based wound dressing.

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P_{normalc =} \frac{2 γ \cos θ}{Re}

…”

Section: Discussionmentioning

confidence: 99%

Physical and biological properties of blend‐electrospun polycaprolactone/chitosan‐based wound dressings loaded with N‐decyl‐N, N‐dimethyl‐1‐decanaminium chloride: An in vitro and in vivo study

et al. 2020

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“…Further, Skagen et al [26] found that constant negative pressure applied to the skin resulted in increased vascular resistance and a pronounced decrease in skin blood flow. Accordingly, NPWT decreases tissue perfusion beneath the wound dressing [36] and in close proximity to the wound area [37] and decreases tissue oxygenation of the foot [38,39].…”

Section: Discussionmentioning

confidence: 99%

Intermittent negative pressure applied to the lower limb increases foot macrocirculatory and microcirculatory blood flow pulsatility in people with spinal cord injury

et al. 2017

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“…According to the articles included, most indicate that TPN is effective and safe [10,18,19,[21][22][23]26]. However, one of them mentions that there are no significant differences in safety and another in effectiveness compared to other types of therapy.…”

Section: Discussionmentioning

confidence: 99%

Nurse Approach in the Treatment of Piabetic Foot Ulcers with the Management of Negative Pressure Therapy

Astasio-Picado¹

2021

J Diabet Res Rev Rep

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The global increase of Diabetes Mellitus represents serious complications for those who suffer from it, the most frequent complications are diabetic foot ulcers and amputations derived from them. Currently, negative pressure therapy (NPT) is used as an advanced therapy for the treatment of this type of ulcers. This novel therapy promises numerous advantages for the nursing approach to patients with diabetic foot ulcers. Therefore, the objective of this narrative review is to prove the effectiveness of the negative pressure therapy as a treatment for diabetic foot ulcers. The search of the articles was carried out in several scientific databases with the help of a searching chain, which combined the keywords and boolean operators. 16 studies were selected, which indicated that NPT as a treatment for diabetic foot ulcers provides benefits such as promoting the formation of granulation tissue, healing and closing of the ulcer in a shorter time, as well as reducing ulcer depth and area and even decreases the bacterial load, the rate of amputations and reulcerations. Hence, NPT is an effective therapy that should be applied to clinical practice

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Influence of Negative-Pressure Wound Therapy on Tissue Oxygenation in Diabetic Feet

Abstract: These results show that NPWT significantly reduces tissue oxygenation levels in diabetic feet.

Cited by 20 publications

References 21 publications

Physical and biological properties of blend‐electrospun polycaprolactone/chitosan‐based wound dressings loaded with N‐decyl‐N, N‐dimethyl‐1‐decanaminium chloride: An in vitro and in vivo study

Physical and biological properties of blend‐electrospun polycaprolactone/chitosan‐based wound dressings loaded with N‐decyl‐N, N‐dimethyl‐1‐decanaminium chloride: An in vitro and in vivo study

Intermittent negative pressure applied to the lower limb increases foot macrocirculatory and microcirculatory blood flow pulsatility in people with spinal cord injury

Nurse Approach in the Treatment of Piabetic Foot Ulcers with the Management of Negative Pressure Therapy

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