Influence of naringin on the myocardial ultrastructure and NF-B expression in rats with diabetic cardiomyopathy

Wu, Keng

doi:10.5897/ajpp12.440

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Naringin reduces myocardial damage by inhibiting the inflammatory reactions mediated by NF-κB and retards the progression of diabetic cardiopathy (Wu et al, 2013). Naringin also protects against high glucose-induced human endothelial cell injury through its antioxidant properties by downregulating CX3CL1 protein and improving mitochondrial function (Li et al, 2017).Naringin decreases malondialdehyde level, the marker of lipid peroxidation, reduction in protein glycation, and activates GSH synthesis in L6 myoblast cell (Dhanya et al, 2015).…”

Section: Naringinmentioning

confidence: 99%

Antidiabetic potential of natural phytochemical antioxidants

FAHIM¹,

RAHMAN²,

NASEEM³

et al. 2022

JCNB

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Diabetes mellitus is a chronic metabolic ailment caused due to complex interactions of genetic and environmental factors (dietary and lifestyle). It causes remarkable morbidity and mortality due to microvascular (retinopathy, nephropathy, and neuropathy) and macrovascular (heart attack, peripheral vascular disease, and stroke) complications. Treatment of microvascular complications focuses on blood sugar control. Although preventing macrovascular complications requires correcting classical cardiovascular risk factors that involve insulin resistance (metabolic) syndrome. The use of traditional drugs adopts several antidiabetic remedies. These drugs are effectivebecause most of these drugs are taken by patients for their entire life and causeseveral adverse effects like diarrhoea, abdominal distention, and flatulence emanate by intaking these drugs. Due to these restrictions,there is a need to explore management strategies in medicinal plants with cost-effective antidiabetic potentials and fewer or negligible side effects. Applying traditional medicine for diabetes and its associated complications has received increasing attention. This review explores the antidiabetic potential of some commonly and extensively used phytochemicals obtained from traditional medicinal plants.

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Section: Naringinmentioning

confidence: 99%

Antidiabetic potential of natural phytochemical antioxidants

FAHIM¹,

RAHMAN²,

NASEEM³

et al. 2022

JCNB

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“…20 NRG is known for its physiological and pharmacological properties including the antihypercholesterolemic, 21 –23 cardioprotection, 24,25 anti-inflammatory, 21,26 –28 antioxidant, 29 –31 and antiapoptotic effects. 32 –34 In addition, most studies found that the NRG could normalize plasma glucose, insulin, glycosylated hemoglobin, and some important enzymes of carbohydrate metabolism in diabetic animals. They also reported that naringin treatment stimulates insulin secretion from remnant pancreatic β-cells and reduces blood glucose levels in diabetic animals.…”

Section: Introductionmentioning

confidence: 99%

Mice pancreatic islets protection from oxidative stress induced by single-walled carbon nanotubes through naringin

et al. 2018

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The growing use of carbon nanotubes (CNTs) emphasizes the importance of its potential toxic effects on the human health. Previous studies proved that CNTs caused oxidative stress and decreased cell viability. On the other hand, reactive oxygen species (ROS) and oxidative stress impaired β-cell functions and reduced the insulin secretion. However, there is not any study on the effects of CNTs on islets and β-cells. Therefore, the present study aimed to evaluate the effects of single-walled CNTs (SWCNTs) on oxidative stress in islets in addition to the protective effects of naringin (NRG) as an antioxidant . We examined the effects of SWCNTs and naringin on islets by 3,4 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay; measurement of insulin secretion, ROS, and malondialdehyde (MDA); activities of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) peroxidase (GSH-Px); and content of GSH and mitochondrial membrane potential (MMP). The MTT assay demonstrated that decreased viability of islets cells was dose-dependent with exposure to SWCNTs. Further studies revealed that SWCNTs decreased insulin secretion and MMP, induced the formation of ROS, increased the level of MDA, and decreased the activities of SOD, GSH-Px, and CAT and content of GSH. Furthermore, the pretreatment of islets with naringin significantly reverted back these changes. These findings revealed that SWCNTs might induce the oxidative stress to pancreatic islets, causing the occurrence of diabetes, and the protective effects of naringin that was mediated by augmentation of the antioxidant defense system of islets. Our research indicated the necessity for further in vivo and in vitro researches on the effects of SWCNTs and naringin on diabetes.

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Naringin protects cardiomyocytes against hyperglycemia-induced injuries in vitro and in vivo

Qin

et al. 2016

Journal of Endocrinology

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We previously reported that naringin (NRG) protects cardiomyocytes against high glucose (HG)-induced injuries by inhibiting the MAPK pathway. The aim of this study was to test the hypothesis that NRG prevents cardiomyocytes from hyperglycemia-induced insult through the inhibition of the nuclear factor kappa B (NF-κB) pathway and the upregulation of ATP-sensitive K + (K ATP ) channels. Our results showed that exposure of cardiomyocytes to HG for 24 h markedly induced injuries, as evidenced by a decrease in cell viability and oxidative stress, and increases in apoptotic cells as well as the dissipation of mitochondrial membrane potential (MMP). These injuries were markedly attenuated by the pretreatment of cells with either NRG or pyrrolidine dithiocarbamate (PDTC) before exposure to HG. Furthermore, in streptozotocin (STZ)-induced diabetic rats and in HG-induced cardiomyocytes, the expression levels of caspase-3, bax and phosphorylated (p)-NF-κB p65 were increased. The increased protein levels were ameliorated by pretreatment with both NRG and PDTC. However, the expression levels of bcl-2 and K ATP and superoxide dismutase (SOD) activity were decreased by hyperglycemia; the expression level of Nox4 and the ADP/ATP ratio were increased by hyperglycemia. These hyperglycemia-induced indexes were inhibited by the pretreatment of cardiomyocytes with NRG or PDTC. In addition, in STZ-induced diabetic rats, we also observed that NRG or PDTC contributed to protecting mitochondrial injury and myocardium damage. This study demonstrated that NRG protects cardiomyocytes against hyperglycemia-induced injury by upregulating K ATP channels in vitro and inhibiting the NF-κB pathway in vivo and in vitro.

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Influence of naringin on the myocardial ultrastructure and NF-B expression in rats with diabetic cardiomyopathy

Cited by 4 publications

References 20 publications

Antidiabetic potential of natural phytochemical antioxidants

Antidiabetic potential of natural phytochemical antioxidants

Mice pancreatic islets protection from oxidative stress induced by single-walled carbon nanotubes through naringin

Naringin protects cardiomyocytes against hyperglycemia-induced injuries in vitro and in vivo

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