Influence of nanotechnology to combat against COVID-19 for global health emergency: A review

Rangayasami, Aswini; Kannan, Karthik; Murugesan, Subban; Radhika, Devi; Sadasivuni, Kishor Kumar; Reddy, Kakarla Raghava; Raghu, Anjanapura V.

doi:10.1016/j.sintl.2020.100079

Cited by 44 publications

(31 citation statements)

References 71 publications

(55 reference statements)

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“…In this regard, nanotechnology is being seriously investigated for its potential in the development of therapeutics, vaccines, diagnostic techniques, and strategies to reduce the healthcare burden. The unique properties of nanoparticles such as their small size, enhanced solubility, better target reachability, improved half-life, reduced side-effects, and surface adaptability are being utilized to bring out a much-needed clinical transformation that could be effective directly against the virus [ 3 , 4 ]. Researchers are now looking into nanotechnology for developing improved assays and nanosensor-based diagnostic techniques, improved delivery of medications, and increased circulation time of the drugs.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology as a Shield against COVID-19: Current Advancement and Limitations

Rai

Bonde

Yadav

et al. 2021

Viruses

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The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global health problem that the WHO declared a pandemic. COVID-19 has resulted in a worldwide lockdown and threatened to topple the global economy. The mortality of COVID-19 is comparatively low compared with previous SARS outbreaks, but the rate of spread of the disease and its morbidity is alarming. This virus can be transmitted human-to-human through droplets and close contact, and people of all ages are susceptible to this virus. With the advancements in nanotechnology, their remarkable properties, including their ability to amplify signal, can be used for the development of nanobiosensors and nanoimaging techniques that can be used for early-stage detection along with other diagnostic tools. Nano-based protection equipment and disinfecting agents can provide much-needed protection against SARS-CoV-2. Moreover, nanoparticles can serve as a carrier for antigens or as an adjuvant, thereby making way for the development of a new generation of vaccines. The present review elaborates the role of nanotechnology-based tactics used for the detection, diagnosis, protection, and treatment of COVID-19 caused by the SARS-CoV-2 virus.

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Section: Introductionmentioning

confidence: 99%

Nanotechnology as a Shield against COVID-19: Current Advancement and Limitations

Rai

Bonde

Yadav

et al. 2021

Viruses

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“…Such as in a recent publish electrochemical detection of SARS-CoV-2 spike (S) protein employed alkaline phosphatase enzyme tagged secondary antibody to catalyze 1 naphthyl phosphate substrate on the surface of a screen-printed carbon electrode (SPCE) [ 94 ]. However, due to the instability of enzymes depending on the environmental condition, nanotechnology stole the limelight in biosensor design [ 93 , 141 ]. Above all of that, the capacity to work with small sample volume, sensor robustness, and high substrate specificity will always employ enzymes as across-the-board sensing elements [ 93 ].…”

Section: Details On Covid-19mentioning

confidence: 99%

“…The color that appeared on the strip can be visualized by naked eyes or can be detected by detectors present in biosensors. Nanotechnology has marked tremendous advantages in colorimetric assays [ 141 ]. AuNP is very convenient because of its attractive optical properties, tunable surface plasmon, and exceptional photostability [ 105 ].…”

Section: Details On Covid-19mentioning

confidence: 99%

“…There are multiple strategies developed in the field of a biosensor that can enhance the sensitivity and efficacy of the sensor. The parameter of these biosensors can be enhanced by either changing the surface property of the sensor, electrochemical property, and binding receptor of the sensor [ 141 , 142 ].…”

Section: Overview Of Biosensing Platforms For Sars-cov-2 Detectionmentioning

confidence: 99%

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A comprehensive review on current COVID-19 detection methods: From lab care to point of care diagnosis

Singh¹,

Datta²,

Ashish³

et al. 2021

Sensors International

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Without a doubt, the current global pandemic affects all walks of our life. It affected almost every age group all over the world with a disease named COVID-19, declared as a global pandemic by WHO in early 2020. Due to the high transmission and moderate mortality rate of this virus, it is also regarded as the panic-zone virus. This potentially deadly virus has pointed up the significance of COVID-19 research. Due to the rapid transmission of COVID-19, early detection is very crucial. Presently, there are different conventional techniques are available for coronavirus detection like CT-scan, PCR, Sequencing, CRISPR, ELISA, LFA, LAMP. The urgent need for rapid, accurate, and cost-effective detection and the requirement to cut off shortcomings of traditional detection methods, make scientists realize to advance new technologies. Biosensors are one of the reliable platforms for accurate, early diagnosis. In this article, we have pointed recent diagnosis approaches for COVID-19. The review includes basic virology of SARS-CoV-2 mainly clinical and pathological features. We have also briefly discussed different types of biosensors, their working principles, and current advancement for COVID-19 detection and prevention.

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“…Since viruses possess designed strategies to infect all living organisms, scientists have been inspired by viruses to design nanomaterials, in particular for targeted drug and gene delivery (Wen and Steinmetz 2016). In particular, it has been predicted that nanotechnology-based pharmaceutical formulations could be powerful to limit the COVID-19 pandemic (Campos et al 2020;Khan et al 2021;Rangayasami et al 2021). Nanoparticles can be tailored for prevention, diagnosis and treatments of the COVID-19 (Vahedifard and Chakravarthy 2021).…”

Section: Why Nanomaterials Are Highly Relevant?mentioning

confidence: 99%

Nanozymes to fight the COVID-19 and future pandemics

et al. 2021

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In 2019, the pandemic induced by the rapid spread of the severe acute respiratory syndrome coronavirus-2 'SARS-CoV-2', also named coronavirus disease 'COVID-19', has rapidly caused serious health, economic, social, and political issues worldwide. This has been accentuated by asymptomatic carriers, fast viral mutations, incoherent lockdown policies, and limited methods of detection and treatment. Nucleic acid tests for COVID-19 are lengthy and complicated, and the rapid antibody tests produce false-negative diagnoses, particularly in the early stage of infection. Moreover, there are no specific and effective medicines available for treatment. Therefore, rapid diagnostics and therapeutics are urgently required. Here, we argue that nanozymesenzyme-mimicking nanoparticles-could be used for faster, more sensitive, and accurate detection and treatment of the COVID-19. Indeed, nanozymes have high surface areas allowing easier bioconjugation for detection, and nanozymes possess integrated drug-functionalization for treatment. Moreover, the size, composition, and surface chemistry of nanozymes can be rationally designed for improved theranostic applications. COVID-19 historyThe COVID-19 appeared in Wuhan, China, due to emergence of a novel strain of coronavirus (Sallard et al. 2021), which was provisionally named '2019-nCoV' by the World Health Organization (WHO). Later, the virus was renamed 'SARS-CoV-2' by the International Committee

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Influence of nanotechnology to combat against COVID-19 for global health emergency: A review

Cited by 44 publications

References 71 publications

Nanotechnology as a Shield against COVID-19: Current Advancement and Limitations

Nanotechnology as a Shield against COVID-19: Current Advancement and Limitations

A comprehensive review on current COVID-19 detection methods: From lab care to point of care diagnosis

Nanozymes to fight the COVID-19 and future pandemics

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