Influence of n-6 and n-3 polyunsaturated fatty acids on the resistance to experimental tuberculosis

Paul, K.; Leichsenring, Michael; Pfisterer, Matthias; Mayatepek, Ertan; Wagner, Dirk; Domann, M.; Sonntag, H.-G.; Bremer, H. J.

doi:10.1016/s0026-0495(97)90003-2

Cited by 49 publications

(51 citation statements)

References 27 publications

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“…In fact, the study of this intracellular pathogen has increased our knowledge of the diverse interactions between this biological mediator and the innate and adaptive immune responses. Moreover, other investigations have also demonstrated the reduction of host immune resistance to different bacteria or viruses in animals fed polyunsaturated fatty acids (3,4,8,28,29).…”

Section: Discussionmentioning

confidence: 98%

Relevance of Dietary Lipids as Modulators of Immune Functions in Cells Infected with Listeria monocytogenes

Puertollano

Pablo

Cienfuegos

2002

Clin Vaccine Immunol

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Nutritional status may have significant importance for the immune system, and particularly, unsaturated fatty acids may serve as modulators of immune functions. Clinical and epidemiological studies have demonstrated that fatty acids are involved in the reduction of the inflammatory processes that occur in diseases characterized by an overactivation of the immune system. At the same time, an increase in susceptibility to infection has also been reported. The importance of immune system modulation by dietary lipids in the presence of an intracellular bacterial pathogen, such as Listeria monocytogenes, was evaluated in the present study. BALB/c mice were divided into four groups which were each fed a low-fat (2.5% by weight) diet, an olive oil (OO; 20% by weight) diet, a fish oil (FO; 20% by weight) diet, or a hydrogenated coconut oil (HCO; 20% by weight) diet for 4 weeks. In each group, lymphocye proliferation was measured, and a reduction in the stimulation index was observed in the FO and HCO groups. Cytotoxicity exerted by L. monocytogenes was increased in the groups fed diets containing OO and FO after 6 h of incubation with the bacterium. An important increase in the production of reactive oxygen species was found in the groups fed the HCO diet after 12 h of incubation with L. monocytogenes. Finally, invasion and adhesion factors were not modified substantially by the action of dietary lipids, although these factors were reduced in cells from mice fed an FO diet. These results underline the importance of several dietary lipids as biological modulators of immune functions and their crucial role in the alteration of host natural resistance.According to present knowledge, many fatty acids contained in the diets of both animals and humans may exert a modulatory effect on immune functions (5, 12). It is generally assumed that the long-chain n-3 polyunsaturated fatty acids eicosapentaenoic acid (20:5[n-3]) and docosahexaenoic acid (DHA; 22: 6[n-3]), contained in fish oil, promote an immunosuppressive function. However, it has also been determined that monounsaturated fatty acids, such as oleic acid (derived from olive oil), rather than the other biological substances contained in this fat, cause an important reduction of numerous immune functions (21). Therefore, as a consequence of these events, many immunological functions, such as lymphocyte proliferation (15,24), cytokine production (15, 24), expression of cell surface molecules (20), natural killer (NK) cell activity (36), and phagocytosis (7), are modulated by the action of fatty acids. As a result, in recent years, numerous studies have indicated the potential role of several dietary lipids in the development of cancer or in the increase in resistance to tumors (9, 31). Similarly, unsaturated fatty acids have been applied in the resolution of inflammatory disorders associated with diseases characterized by an overreactivation of the immune system, such as rheumatoid arthritis (22, 23), psoriasis (2), and multiple sclerosis (1,18). However, despite the benefi...

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Section: Discussionmentioning

confidence: 98%

Relevance of Dietary Lipids as Modulators of Immune Functions in Cells Infected with Listeria monocytogenes

Puertollano

Pablo

Cienfuegos

2002

Clin Vaccine Immunol

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“…Several studies have indicated the involvement of long-chain n-3 PUFA in the modulation of natural resistance against different infectious agents such as Salmonella typhimurium serovar Typhimurium (Chang, 1992), Mycobacterium tuberculosis (Paul, 1997), Listeria monocytogenes (Fritsche, 1997;de Pablo, 2000a), influenza virus (Byleveld, 2000;Byleveld, 1999), or parasites (Blok, 2002). Experimental infection with L. monocytogenes after administration of diets containing fish oil has reduced the percentage of animals' survival indicating a suppression of resistance due to dietary lipid administration (de Pablo, 2000a;Fritsche, 1997).…”

Section: Resistance To Infectious Agentsmentioning

confidence: 99%

Olive oil and immune system functions: potential involvement in immunonutrition

Pablo¹,

Puertollano²,

Cienfuegos³

2004

Grasas y Aceites

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“…Despite this, several studies have reported that an excess intake of n-3 polyunsaturated fatty acids may cause undesirable effects in both humans and animals, because they are able to reduce host immune resistance against infectious microorganisms (1,11). Thus, numerous investigations have indicated that diets containing n-3 polyunsaturated fatty acids enhance susceptibility to infection by Listeria monocytogenes (8,13,23), Salmonella enterica serovar Typhimurium (7), Mycobacterium tuberculosis (21), or Pseudomonas aeruginosa (22), whereas other recent observations have reported that these diets increase immune resistance against Klebsiella pneumoniae (2,3,27), although these effects could not be demonstrated in infection with Streptococcus pneumoniae (27). Therefore, it is possible that the consequences derived from the reduction of immune resistance by n-3 polyunsaturated fatty acids may also depend on the type of microorganisms and their pathogenic mechanisms.…”

mentioning

confidence: 99%

Assessment of Interleukin-12, Gamma Interferon, and Tumor Necrosis Factor Alpha Secretion in Sera from Mice Fed with Dietary Lipids during Different Stages ofListeria monocytogenesInfection

Puertollano

Cruz-Chamorro

Puertollano

et al. 2005

Clin Vaccine Immunol

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Recent experimental observations have determined that long-chain n-3 polyunsaturated fatty acids suppress immune functions and are involved in the reduction of infectious disease resistance. BALB/c mice were fed for 4 weeks with one of four diets containing either olive oil (OO), fish oil (FO), hydrogenated coconut oil, or a low fat level. Interleukin-12p70 (IL-12p70), gamma interferon (IFN-␥), and tumor necrosis factor alpha (TNF-␣) production in the sera of mice fed these diets and challenged with Listeria monocytogenes were determined by enzyme-linked immunosorbent assay. In addition, bacterial counts from spleens of mice were carried out at 24, 72, or 96 h of infection. Here, we quantified an initial diminution of production of both IL-12p70 and IFN-␥, which appear to play an important role in the reduction of host resistance to L. monocytogenes infection. In addition, an efficient elimination of L. monocytogenes was observed in spleens of mice fed a diet containing OO at 96 h of infection, despite reductions in IL-12p70 and TNF-␣ production, suggesting an improvement of immune resistance. Overall, our results indicate that the initial reduction of both IL-12 and IFN-␥ production before L. monocytogenes infection represents the most relevant event that corroborates the impairment of immune resistance by n-3 polyunsaturated fatty acids during the different stages of infection. However, we speculate that the modulation of other cytokines must be also involved in this response, because the alteration of cytokine production in mice fed an FO diet in a late phase of L. monocytogenes infection was similar to that in mice fed OO, whereas the ability to eliminate this bacterium from the spleen was improved in the latter group.

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Influence of n-6 and n-3 polyunsaturated fatty acids on the resistance to experimental tuberculosis

Cited by 49 publications

References 27 publications

Relevance of Dietary Lipids as Modulators of Immune Functions in Cells Infected with Listeria monocytogenes

Relevance of Dietary Lipids as Modulators of Immune Functions in Cells Infected with Listeria monocytogenes

Olive oil and immune system functions: potential involvement in immunonutrition

Assessment of Interleukin-12, Gamma Interferon, and Tumor Necrosis Factor Alpha Secretion in Sera from Mice Fed with Dietary Lipids during Different Stages ofListeria monocytogenesInfection

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