Influence of multiple genes on the magnitude of the antibody response to bacterial polysaccharide antigens

Baker, Phillip J.; Rudbach, Jon A.; Prescott, Benjamin; Caldes, George; Evans, Charles B.; Stashak, Philip W.

doi:10.1128/iai.45.1.56-61.1984

Cited by 11 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CBA/N mice produce normal primary and secondary antibody responses to E. coli 0113 LPS (28), whereas RIIIS/J mice do not. Since male and female (RIIIS/J x BALB/cByJ)F1 mice can produce anti-polysaccharide antibody responses of the same order of magnitude, the low responsiveness of RIIIS/J mice is not an X-linked trait (7,29). Furthermore, female (CBA/N…”

Section: Resultsmentioning

confidence: 99%

“…RIIIS/J and RIII/AnN mice also make low antibody responses to bacterial dextran and type III pneumococcal polysaccharide, or SSS-Ill (29). Like CBA/N mice, both RIIIS/J and RIII/AnN mice have small spleens and low levels of serum immunoglobulin M (IgM) (7,40); however, the genetic defect of RIIIS/J mice is independent from the defect of CBA/N mice and is due to the absence of an autosomal dominant gene(s) which influences serum IgM levels and the magnitude of the antibody response to several polysaccharide antigens (7,29).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Characterization of the immunodeficiency of RIIIS/J mice: immune response to polysaccharide antigens

et al. 1990

Self Cite

View full text Add to dashboard Cite

RIIIS/J mice lack an autosomal dominant gene(s) that influences the magnitude of the antibody response to several polysaccharide antigens of bacterial origin. Low responsiveness is demonstrable whether polysaccharide is administered as a T-helper-cell-independent or-dependent antigen conjugated to an immunogenic carrier; however, RIIS/J mice make good anti-hapten antibody responses to haptenated polysaccharides. The low antibody responses of RIIIS/J mice to type III pneumococcal polysaccharide do not appear to be the results of an imbalance in the activity of regulatory T lymphocytes. Compared with other strains of mice, RIIIS/J mice elicit low antibody responses to lipopolysaccharide (LPS). They do not develop a cyclic primary or secondary antibody response to Escherichia coli 0113 LPS; the latter is not due to a lack of mitogenic response to E. coli 0113 LPS. They also produce auto-anti-idiotypic antibody after being immunized with trinitrophenyl-Ficoll.

show abstract

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Characterization of the immunodeficiency of RIIIS/J mice: immune response to polysaccharide antigens

et al. 1990

Self Cite

View full text Add to dashboard Cite

show abstract

“…2). Inbred strains of mice sbow different antibody responses to pneumococcal polysaccbaride antigens both with regard to the 'background' antibody levels in non-immunized mice [5,19] and the response after primary immunization [5,20]. Tbe genetic background also influences the virulence of pneumococci in mice [21], as well as protection in mice induced after pneumococcal vaccination (I.S.…”

Section: Discussionmentioning

confidence: 99%

The Antibody Response to Secondary Immunization with Pneumococcal Polysaccharides in Mice

Aaberge¹,

Løvik²

1995

Scand J Immunol

View full text Add to dashboard Cite

The benefit of re-immunization with pneumococcal polysaccharide vaccine is an important question in clinical practice. In an experimental model, BALB/c and CBA/J mice were re-immunized s.c. with a 23-valent pneumococcal polysaccharide vaccine at various time intervals after a first immunization with the same vaccine. The antibody response after the secondary immunization showed similar kinetics as after primary immunization, and was mainly an IgM antibody response. Re-immunization at 28 days or earlier induced a decrease in the serum antibody levels to the vaccine. Reimmunization at 120 days or later induced higher antibody levels than after the first immunization. Significant increases in antibody levels to serotypes 1, 4, 7F and 19F out of six serotypes tested were observed. In CBA/J mice, but not in BALB/c mice, the dose used for primary immunization appeared to influence the magnitude of the antibody response to secondary immunization. Our results indicate that the time interval between primary and secondary immunization is an important determinant with regard to the magnitude of the antibody response to re-immunization with pneumococcal polysaccharide vaccine.

show abstract

“…Numbers of antibody-producing plaque-forming cells (PFC) making antibody specific for the immunogen provided a measure of the antibody response produced. PFC making antibody of the immunoglobulin M (IgM) class (>90% of all SSS-III-specific PFC found [2,9]) were detected in individual mice by a slide version of the technique of localized hemolysis-in-gel, using indicator sheep erythrocytes coated with SSS-IlI (13) or dextran (8).…”

Section: Methodsmentioning

confidence: 99%

Enrichment of suppressor T cells by means of binding to monophosphoryl lipid A

et al. 1990

Self Cite

View full text Add to dashboard Cite

The binding and elution of spleen cells from plastic dishes coated with monophosphoryl lipid A (MPL) resulted in a greater than 1,000-fold enrichment of antigen-specific suppressor T-cell (TS) activity when spleen cells from mice 18 to 24 h after exposure to a low dose of type III pneumonococcal polysaccharide (SSS-III) were used. The removal of MPL-adherent TS cells resulted in an increase in the degree of amplifier T-cell (TA) activity present in the remaining MPL-nonadherent cell fraction; however, both TS and TA activities were found in the MPL-adherent cell fraction when spleen cells from mice 4 days after immunization with an optimal dose of SSS-III were examined. These findings, as well as others, suggest that both TS and TA, once activated, acquire a cell surface receptor that enables them to bind to MPL. Because of differences in the kinetics for the activation of TS and TA during the course of the antibody response and the fact that TS, but not TA, activity appears as early as 18 to 24 h after exposure to SSS-III, it is possible to use this experimental approach to obtain cell suspensions greatly enriched in TS activity.

show abstract

Influence of multiple genes on the magnitude of the antibody response to bacterial polysaccharide antigens

Cited by 11 publications

References 27 publications

Characterization of the immunodeficiency of RIIIS/J mice: immune response to polysaccharide antigens

Characterization of the immunodeficiency of RIIIS/J mice: immune response to polysaccharide antigens

The Antibody Response to Secondary Immunization with Pneumococcal Polysaccharides in Mice

Enrichment of suppressor T cells by means of binding to monophosphoryl lipid A

Contact Info

Product

Resources

About